Hodgkin's disease - part 2: management of advanced disease, relapsed disease, and long-term complications of treatment

Over the past 25 years there have been dramatic improvements in our understanding of the epidemiology, biology, natural history, and treatment of Hodgkin's disease. Hodgkin's disease is one of the few cancers where both chemotherapy and radiation therapy have provided dramatic improvements in the cure of this once uniformly fatal disease. Part 2 of the refresher course on Hodgkin's disease will include a review of: 1) Treatment of stage III and IV disease including the role of radiation therapy alone for stage III disease 2) The role of adjuvant radiation therapy in advanced Hodgkin's disease 3) The use of different chemotherapy regimens including MOPP vs ABVD, ABVD vs hybrid chemotherapy, and the development of new chemotherapy regimens 4) Treatment of refractory and relapsed Hodgkin's disease including prognostic factors and role of salvage chemotherapy vs. high dose therapy and hematopoietic stem cell rescue and 5) An overview of the long-term complications of treatment and their impact on new strategies for treatment for Hodgkin's disease