Published December 2019 | Version v1
Journal article Metadata-only

Fusion Radiomics Features from Conventional MRI Predict MGMT Promoter Methylation Status in Lower Grade Gliomas

Creators

  • 1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)
  • 2. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)
  • 3. Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing (China)
  • 4. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)

Description

Highlights: • MRI radiomics is reliable in predict MGMT methylation status in lower grade glioma. • Fusion radiomics features from different series increase the prediction performance. • Three dimensional imaging data may reflect detailed characteristics of tumor. - Abstract: PurposeThe methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has been proven to be a prognostic and predictive biomarker for lower grade glioma (LGG). This study aims to build a radiomics model to preoperatively predict the MGMT promoter methylation status in LGG.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.ejrad.2019.108714

Additional details

Identifiers

DOI
10.1016/j.ejrad.2019.108714;
PII
S0720048X1930364X;

Publishing Information

Journal Title
European Journal of Radiology
Journal Volume
121
Journal Page Range
p. 108714
ISSN
0720-048X
CODEN
EJRADR

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51013528
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MARKERS; DNA; FORECASTING; GLIOMAS; METHYL TRANSFERASES; METHYLATION; NMR IMAGING; PERFORMANCE; POLYMERASE CHAIN REACTION; PROMOTERS; THREE-DIMENSIONAL CALCULATIONS; THREE-DIMENSIONAL LATTICES
Descriptors DEC
CARBON-GROUP TRANSFERASES; CHEMICAL REACTIONS; CRYSTAL LATTICES; CRYSTAL STRUCTURE; DIAGNOSTIC TECHNIQUES; DISEASES; ENZYMES; GENE AMPLIFICATION; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; TRANSFERASES

Optional Information

Notes
© 2019 Published by Elsevier B.V.