In vivo respiratory toxicology of cooking oil fumes: Evidence, mechanisms and prevention

Highlights: • Cooking oil fumes (COF) has been recognized as a major indoor air pollutant. • Epidemiological studies reported various health effects of COF, but toxicological studies are lacking. • We conduct a systematic study to examine the toxicological effects of COF on rat lungs. • We found key evidence and biomarkers of the toxicity of COF. • Vitamin E can effectively prevent COF-induced toxicological effects. As cooking is an essential part of people's daily life, cooking oil fumes (COF) has been recognized as one of the major indoor air pollutant. Mounting epidemiological evidence has indicated that COF exposure is significantly associated with an increased risk of various health effects including lung cancer, but toxicological studies are very limited.