Published May 1983
| Version v1
Journal article
Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells
Creators
- 1. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence
Description
Cultured rat lung fibroblasts (F-cells) and Walker rat carcinoma cells (WRC-cells) labeled with 51Cr were exposed to the following antitumor drugs alone or with O3: carmustine (BCNU), doxorubicin (Dox), cisplatin (CPt), mitomycin C (Mit C) or vitamin K3 (Vit K). Release of 51Cr (cell injury) was greater for F-cells than WRC-cells with any single treatment. Pretreatment with any drug (400 microM), except for Vit K with WRC-cells, did not significantly increase O3-induced loss of 51Cr. Co-exposure of F-cells to drugs and O3 resulted in a marked potentiation of O3-induced injury with Vit K, and an inhibition with Dox
Additional details
Publishing Information
- Journal Title
- Res. Commun. Chem. Pathol. Pharmacol.
- Journal Volume
- 40
- Journal Issue
- 2
- Series
- Res. Commun. Chem. Pathol. Pharmacol.
- Journal Page Range
- 279-287
- ISSN
- 0034-5164
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 15021265
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL EFFECTS; CELL CULTURES; CHROMIUM 51; DOXORUBICIN; EXPERIMENTAL NEOPLASMS; FIBROBLASTS; LABELLING; LUNGS; MITOMYCIN; OZONE; RATS; TRACER TECHNIQUES; VITAMIN K
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; ANTIBIOTICS; ANTIMITOTIC DRUGS; AROMATICS; BETA DECAY RADIOISOTOPES; BODY; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; QUINONES; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; VERTEBRATES; VITAMINS