Published September 2000 | Version v1
Journal article Metadata-only

Protective effects of vitamin C against gamma-ray induced wholly damage and genetic damage

Creators

  • 1. Suzhou Univ (China). Dept. of Preventive Medicine

Description

Objective: Protective effects of supplemental vitamin C against 60Co-gamma-ray induced wholly damage and genetic damage was investigated in mice. Method: Mice were divided into normal control group, irradiation control group and vitamin C experimental group 1,2,3 (which were orally given vitamin C 15, 30, 45 mg/kg.bw for 10 successive days respectively prior to gamma-ray irradiation). Micronuclei in the bone marrow polychromatophilic erythrocytes in each group of mice were examined and the 30 day survival rate of mice following whole-body 5.0 Gy γ irradiation were also determined. Results: Supplemental vitamin C prior to gamma-rays irradiation can significantly decrease bone marrow PECMN rate of mice and increase 30 day survival rate and prolong average survival time. The protection factor is 2.09. Conclusion: Vitamin C has potent protective effects against gamma irradiation induced damage in mice. In certain dose range, vitamin C can absolutely suppress the gamma-rays induced genetic damage in vivo

Additional details

Publishing Information

Journal Title
Acta Academiae Medicinae Suzhou
Journal Volume
20
Journal Issue
9
Journal Page Range
p. 793-795
ISSN
1000-5749

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
32016957
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ASCORBIC ACID; COBALT 60; GAMMA RADIATION; MICE; RADIATION INJURIES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; COBALT ISOTOPES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES; VITAMINS; YEARS LIVING RADIOISOTOPES