Published February 2003 | Version v1
Journal article Metadata-only

The characteristics and mechanism of apoptosis in K562 cells induced by radionuclides strontium-89

Creators

  • 1. Suzhou Univ., Suzhou (China). No. 1 Affiliated Hospital

Description

In this paper, apoptosis and expressions of bcl-2 and bax protein in K562 cells exposed to different doses of strontium-89 were studied. Six hours after the irradiation, characteristics of apoptosis and necrosis appeared in the K562 cells. The apoptosis and necrosis in the cells irradiated for 6, 9, 12, 24 and 48h were significantly higher than the control. The expression of bcl-2 decreased after the irradiation, whereas bax had no obvious changes. The results suggested that the apoptosis of K562 cells induced by exposure to 89Sr might be regulated by reduced expression of bcl-2 and bcl-2/bax ratio

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
21
Journal Issue
1
Journal Page Range
p. 77-80
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
35020640
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
APOPTOSIS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; CYTOLOGICAL TECHNIQUES; DOSE-RESPONSE RELATIONSHIPS; DOUBLE LABELLING; EXPERIMENTAL DATA; FLUORESCENCE SPECTROSCOPY; INTEGRAL DOSES; IRRADIATION; NECROSIS; RADIOACTIVITY; STATISTICS; STRONTIUM 89; TIME DEPENDENCE; TUMOR CELLS
Descriptors DEC
ALKALINE EARTH ISOTOPES; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; DATA; DAYS LIVING RADIOISOTOPES; DOSES; EMISSION SPECTROSCOPY; EVEN-ODD NUCLEI; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLING; MATHEMATICS; NUCLEI; NUMERICAL DATA; PATHOLOGICAL CHANGES; RADIATION DOSES; RADIATION EFFECTS; RADIOISOTOPES; SPECTROSCOPY; STRONTIUM ISOTOPES