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[en] This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors' Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance
Background and PurposeData on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.
MethodsA retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.
ResultsAmong 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0–2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32–1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39–1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50–2.09; P = 0.93) neither in safety endpoints between the two groups.
ConclusionsPeriprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.
[en] In the past, the selection of representative accidents for refined analysis from the numerous scenarios identified in hazards analyses (HAs) has involved significant judgment and has been difficult to defend. As part of upgrading the Final Safety Analysis Report (FSAR) for the TA-55 plutonium facility at the Los Alamos National Laboratory, an accident selection process was developed that is mostly mechanical and reproducible in nature and fulfills the requirements of the Department of Energy (DOE) Standard 3009 and DOE Order 5480.23. Among the objectives specified by this guidance are the requirements that accident screening (1) consider accidents during normal and abnormal operating conditions, (2) consider both design basis and beyond design basis accidents, (3) characterize accidents by category (operational, natural phenomena, etc.) and by type (spill, explosion, fire, etc.), and (4) identify accidents that bound all foreseeable accident types. The accident selection process described here in the context of the TA-55 FSAR is applicable to all types of DOE facilities
[en] This report includes the issuances received during the specified period from the Commission, the Atomic Safety and Licensing Boards, the Administrative Law Judges, the Directors' Decisions, and the Decisions on Petitions for Rulemaking
[en] Procedures establish how an organization performs specific tasks to accomplish its basic goals and objectives. In 1990, the US Department of Energy (DOE) started the process of defining requirements to be used for procedures throughout the DOE nuclear complex. In response to the customer needs of the complex, the department's initial steps in this process were to develop two documents: a writer's guide for technical procedures and the principles of procedure writing upon which it was based. The US Nuclear Regulatory Commission and Institute for Nuclear Power Operations literature addresses the control and use of procedures. There was, however, no regulatory guidance on developing and managing a procedure system. In 1991, an effort was undertaken to provide such guidance for DOE nuclear facilities. A companion paper by Grider and Plung describes how a performance-tested advisory group developed this guidance. This paper describes the procedure system principles that were developed through this process
[en] This compilation consists of bibliographic data and abstracts for the formal regulatory and technical reports issued by the U.S. Nuclear Regulatory Commission (NRC) Staff and its contractors. This compilation is published quarterly and cummulated annually. Reports consist of staff-originated reports, NRC-sponsored conference reports, NRC contractor-prepared reports, and international agreement reports
[en] The objective of this investigation is to evaluate how visual perception varies as the rural landscape is altered by human interventions of varying character. An experiment is carried out using Semantic Differential Analysis to analyse the effect of the character and the type of the intervention on perception. Interventions are divided into elements of “permanent industrial character”, “elements of permanent rural character” and “elements of temporary character”, and these categories are sub-divided into smaller groups according to the type of development. To increase the reliability of the results, the Intraclass Correlation Coefficient tool, is applied to validate the semantic space of the perceptual responses and to determine the number of subjects required for a reliable evaluation of the scenes.
[en] Fermilab has adopted the Source Evaluation Board (SEB) method for procuring certain major technical components of the Fermilab Main Injector. The SEB procedure is designed to ensure the efficient and effective expenditure of Government funds at the same time that it optimizes the opportunity for attainment of project objectives. A qualitative trade-off is allowed between price and technical factors. The process involves a large amount of work and is only justified for a very limited number of procurements. Fermilab has gained experience with the SEB process in awarding subcontracts for major subassemblies of the Fermilab Main Injector dipoles