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Background and PurposeData on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.
MethodsA retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.
ResultsAmong 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0–2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32–1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39–1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50–2.09; P = 0.93) neither in safety endpoints between the two groups.
ConclusionsPeriprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.
[en] Objective: To discuss the effect of a new teaching mode for refresher physicians in interventional radiology. Methods: Based on the refresher physician's clinical and theoretical basis in interventional radiology, a specialized and experienced interventional radiologist was designated as the tutor for each refresher physician. Centralized training and individual teaching were efficaciously combined, and the specialized training was individually designed. Results: The following-up investigation indicated that all the refresher physicians obtained excellent training results from this new teaching mode. Conclusion: This new teaching scheme is helpful for the refresher physicians to comprehensively improve their abilities to independently accomplish various interventional procedures. (authors)
[en] Chitosan is a chitin derivative that is distinguished only by the radical group CH3.CO on the polymer structure. Chitosan is a chemical compound derived from the biological material of chitin, an organic compound that is abundant after cellulose. Chitin is generally obtained from several groups of mushrooms and is also found in the shells of animals such as shrimp, crabs and other animals especially from the sea. In this purification process the kitosan used is derived from shrimp skin. This resource is used because it aims to expand the use of shrimp waste. This process of chitosan purification aims to identify the total molecular weight present in the chitosan. The improvement of this chitosan purification procedure is carried out because the existing techniques to purify chitosan give low yield. This poses a problem in terms of process efficiency and increases the cost of purification as well as excessive alcohol consumption and can pollute the environment. Among the objectives of this study is to study the quantity of chitosan obtained when the concentration of NaOH/ KOH is increased/ PH. In addition, it aims to study the precipitation of chitosan in water compared to alcohol as well as to test chitosan purified using new techniques compared to existing techniques. The purification method carried out is by using a mixture of chitosan with other chemicals such as NaOH/ KOH, ethanol, sodium acetate, acitate acid and water. As well as the equipment used are PH meter, centrifuge, centrifuge tube, stirrer, Freez drier and also FTIR machine. This purification technique is expected to increase the purification yield by up to 50 % and can reduce alcohol consumption by up to 100 %. (author)
[en] The low-level effluent treatment plant (LLETP) treats effluent contaminated with radionuclides at concentration or activities greater than clearance levels, as established by the regulatory body. This study concerns the development of a new operational procedure for the treatment of low-level liquid radioactive waste containing alpha and gamma type effluents. Treatment of effluents will be by a flocculation-coagulation method, also known as chemical precipitation process. Therefore, a jar test will be used to simulate the flocculation-coagulation process and to determine the right amount of treatment chemicals that should be used. Analyses of the effluents before and after treatment were also done to measure success. Parameters used for this analysis were pH, temperature, conductivity, total dissolved solids, suspended solids, Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD) and activity. (author)
[en] Objective: To discuss the impact of the dynamic changes of nursing scheduling mode on nurse's subjective well-being. Methods: During the past 7 years, 31 intervention specialist nurses had been randomly selected and their subjective well-being degree was evaluated through interviews, tracking observation and questionnaire. The nurse's subjective well-being state in carrying out four-fold nursing scheduling mode was analyzed. Results: The subjective well-being degree of nurses was gradually improved with each change of nursing scheduling mode. Conclusion: According to the development and changes of the department, prompt adjustment of nursing scheduling mode can alleviate the working pressure on the nurses,arouse their occupational enthusiasm, promote team coordination and thus increase nurse's subjective well-being. (authors)
[en] Objective: To investigate the postgraduate training mode of interventional radiology which can fit the development of modern medicine. Methods: The current status and issues concerning the training mode for postgraduates in the field of interventional radiology were investigated and analyzed. Results: Training mode for interventional radiology postgraduates was established according to the professional characteristics of interventional radiology, the characteristics of interventional radiology postgraduates. The curriculum was reasonably set up, the examination system was improved, and education system guided by supervisor team was established. Strict administration for postgraduates was carried out. Conclusion: The establishment of a suitable training program is the important guarantee for the successful training of interventional radiology postgraduates that adapts to the development of modern medicine. (authors)