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Background and PurposeData on safety and efficacy of periprocedural use of heparin are limited during treatment of acute ischemic stroke patients with anterior circulation tandem occlusion. This study aimed to investigate the impact of heparin use during endovascular therapy of anterior circulation tandem occlusions on the functional and safety outcomes.
MethodsA retrospective analysis of the multicenter observational TITAN registry was performed. Patients with anterior circulation tandem occlusion and treated with endovascular therapy (EVT) were included, with or without extracranial carotid intervention. We divided patients into two groups based on periprocedural heparin use (heparin vs. non-heparin). The dose of intravenous unfractionated heparin ranged from 1500 to 2500 I.U. Primary study endpoint was 90-day Modified Rankin Scale (mRS). Secondary study endpoint included angiographic and safety endpoints such as hemorrhagic complications. A propensity-score-matched analysis was performed.
ResultsAmong 369 patients, heparin was used in 68 patients (18.4%). In the propensity-score-matched cohort, favorable outcome (mRS 0–2) occurred in 51.3% in heparin group and 58.0% in non-heparin group (matched OR, 0.76; 95% CI, 0.32–1.78; P = 0.52). Similar result was found in propensity-score-adjusted cohort (adjusted OR, 0.72; 95%CI, 0.39–1.32; P = 0.28). Likewise, there was no difference in the rate of successful reperfusion (mTICI 2b-3) (propensity-score-adjusted OR, 1.03; 95%CI, 0.50–2.09; P = 0.93) neither in safety endpoints between the two groups.
ConclusionsPeriprocedural heparin use during EVT of anterior circulation tandem occlusions was not associated with better functional, angiographic or safety outcomes. These findings are applicable for low doses of heparin, and further studies are warranted.
[en] Chitosan is a chitin derivative that is distinguished only by the radical group CH3.CO on the polymer structure. Chitosan is a chemical compound derived from the biological material of chitin, an organic compound that is abundant after cellulose. Chitin is generally obtained from several groups of mushrooms and is also found in the shells of animals such as shrimp, crabs and other animals especially from the sea. In this purification process the kitosan used is derived from shrimp skin. This resource is used because it aims to expand the use of shrimp waste. This process of chitosan purification aims to identify the total molecular weight present in the chitosan. The improvement of this chitosan purification procedure is carried out because the existing techniques to purify chitosan give low yield. This poses a problem in terms of process efficiency and increases the cost of purification as well as excessive alcohol consumption and can pollute the environment. Among the objectives of this study is to study the quantity of chitosan obtained when the concentration of NaOH/ KOH is increased/ PH. In addition, it aims to study the precipitation of chitosan in water compared to alcohol as well as to test chitosan purified using new techniques compared to existing techniques. The purification method carried out is by using a mixture of chitosan with other chemicals such as NaOH/ KOH, ethanol, sodium acetate, acitate acid and water. As well as the equipment used are PH meter, centrifuge, centrifuge tube, stirrer, Freez drier and also FTIR machine. This purification technique is expected to increase the purification yield by up to 50 % and can reduce alcohol consumption by up to 100 %. (author)
[en] The low-level effluent treatment plant (LLETP) treats effluent contaminated with radionuclides at concentration or activities greater than clearance levels, as established by the regulatory body. This study concerns the development of a new operational procedure for the treatment of low-level liquid radioactive waste containing alpha and gamma type effluents. Treatment of effluents will be by a flocculation-coagulation method, also known as chemical precipitation process. Therefore, a jar test will be used to simulate the flocculation-coagulation process and to determine the right amount of treatment chemicals that should be used. Analyses of the effluents before and after treatment were also done to measure success. Parameters used for this analysis were pH, temperature, conductivity, total dissolved solids, suspended solids, Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD) and activity. (author)
[en] Each system runs with the aim of achieving organisational objectives through the management system. However, even though it has been anticipated in various ways through various kinds of safety engineering approaches, incidents and even severe accidents are still possible to be happen. Management systems with their derivative documents like standard operating procedures are prepared to keep the system operating under normal conditions. However, such management system tools are sometimes cannot be applied in an emergency condition which requires a beyond ordinary action. That action is becoming the scope of resilience engineering in the effort to restore the system into normal conditions and/or to avoid more severe accidents. This article explaining the concepts of resilience engineering, how this concept should be applied together with the management system through the spectrum leadership approach as an effort to anticipate events that possibly can lead to severe accidents. This study shows that the resilience engineering, system management and spectrum leadership are very close correlated and have to be owned by all levels of personnel in the high-risk installation organization. (author)
[en] Stevia rebaudiana has recently gained the attention of food industry as one of the natural sweeteners. The sweet flavor is contributed by the glycosides compound included stevioside, rebaudiosides A to F, rubusoside, steviolmonoside, steviolbioside, and dulcoside A. Among these glycosides, the rebaudioside A and stevioside are 70% of the total glycosides in stevia. Therefore, they were used as stevia chemical markers in this study. The aim of the work reported here was to develop the extraction method of stevia using Hot Water Extraction (HWE) technique. In this paper, the extraction, precipitation and separation processes involved in HWE techniques for stevia were studied and developed. The glycosides yield from each processes were analyzed by High Performance Liquid Chromatography (HPLC). Approximately 283.5 mg purified glycosides contained of rebaudioside A and stevioside was quantified by High Performance Liquid Chromatography (HPLC) in HWE. Therefore, from the obtained results suggest the HWE is an efficient technique for stevia extraction. (author)
[en] Instability in uniform motion flows occurs when continues waves take over dynamic waves. In those cases primary uniform motion of the flow looses its stability and waves appear on free surface of the flow. The issue of prediction of waves occurrence on free surface are discussed in the paper. The calculations are made for both, cohesive debris flows (non Newtonian liquid) and water flows (Newtonian liquid) in order to control and secure stability of ecological situation in the bed and surrounding medium of water flow. (author)
[en] In January 2020, the Austrian legislature worked intensively on the complete implementation of Directive 2013/59 /Euratom into national law - the publication of the new version of the Austrian Radiation Protection Act and the associated ordinances is imminent. Fortunately, for the organization of radiation protection within companies revolutionary news are not expected yet.
[de]Im Januar 2020 arbeitete die österreichische Legislative (weiterhin) mit Hochdruck an der vollständigen Umsetzung der Richtlinie 2013/59 /Euratom in nationales Recht - die Publikation der Neufassung des österreichischen Strahlenschutzgesetzes und der zugehörigen Verordnungen steht unmittelbar bevor. Für die Organisation des Strahlenschutzes innerhalb von Betrieben sind glücklicherweise aller Voraussicht noch keine umwälzenden Neuigkeiten zu erwarten.