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[en] As researchers strive to understand the interplay between the complex molecular systems that make up living cells, tools for characterizing the interactions between the various players involved have developed. Small-angle neutron scattering (SANS) plays an important role in building a molecular-level understanding of the structures of macromolecular systems that make up cells. SANS is widely applicable to the study of biological structures including, but by no means limited to, protein-protein or protein-nucleic acid complexes, lipid membranes, cellular scaffolding, and amyloid plaques. Here, we present a brief description of the technique as it is commonly applied to the study of biological systems and an overview instrumentation that is available at the various facilities around the world.
[en] Modern single molecule fluorescence microscopy offers new, highly quantitative ways of studying the systems biology of cells while keeping the cells healthy and alive in their natural environment. In this context, a quantum optical technique, photon antibunching, has found a small niche in the continuously growing applications of single molecule techniques to small molecular complexes. Here, we review some of the most recent applications of photon antibunching in biophotonics, and we provide a guide for how to conduct photon antibunching experiments at the single molecule level by applying techniques borrowed from time-correlated single photon counting. We provide a number of new examples for applications of photon antibunching to the study of multichromophoric molecules and small molecular complexes
[en] This document describes the National Radiobiology Archives (NRA) J. Newell Stannard Collection. Items in the Stannard Collection are available upon written request. The written correspondence should identify specific items, or the topic of the items, to be retrieved from the NRA holdings. The NRA is a Department of Energy Office of Health and Environmental Research (DOE/OHER) funded project at Pacific Northwest Laboratory (PNL). Dr. Charles R. Watson, telephone (509) 376-3483, is the project director. The NRA project is a comprehensive effort to gather, organize, and catalog data, tissues, and documents related to radiobiology studies. This archiving activity will provide future researchers with information for statistical analyses to compare results of these and other studies and materials for analysis and application of advanced molecular biology techniques