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[en] Highlights: • NG valves demonstrated lower rates of significant AKI, PVR and bleeding compared to EG valves. • Rates of 30-day mortality, new PPI, and cerebrovascular events were similar between NG and EG valves. • NG valves showed lower tendency of MVC compared to EG valves. - Abstract: BackgroundNew-generation (NG) valves for transcatheter aortic valve implantation (TAVI) has recently been widely used in real-world practice, yet its comparative outcomes with early-generation (EG) valves remain under-explored.
[en] Highlights: • CABG is associated with lower MACE when compared to old generation stents but not when compared to new generation DES. • There is no significant difference between CABG and PCI in mortality, CVA and MI. • CABG is associated with lower repeat revascularization when compared to PCI. - Abstract: BackgroundMost data guiding revascularization of multivessel disease (MVD) and/or left main disease (LMD) favor coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI). However, those data are based on trials comparing CABG to bare metal stents (BMS) or old generation drug eluting stents (OG-DES). Hence, it is essential to outcomes of CABG to those of new generation drug eluting stents (NG-DES).
[en] Introduction: It is customary to consider deaths that occur within 90 days of surgery as caused by that surgery. However, such practice may overestimate the true short-term mortality rates after radical prostatectomy (RP). Indeed, treatment-unrelated events might affect short-term mortality rates. We assess RP-specific excess short-term mortality. Methods: We performed a retrospective analysis of a population based cohort of 59 010 patients (RP = 28 281 and external beam radiation therapy [EBRT] as reference group, n = 30 729) who were treated between 1998 and 2005 for non-metastatic prostate cancer. Using univariate and multivariate logistic regression analyses, we assessed the rates of 30-, 60- and 90-day mortality after either RP or EBRT. Results: Within the cohort, 30-, 60- and 90-day mortality rates were 0.2, 0.5 and 0.6%, and 0.1, 0.4 and 0.6% for RP and EBRT patients, respectively. This resulted in overall 30-, 60, and 90- day mortality differences of 0.1, 0.1 and 0%, respectively. After stratification according to age and Charlson comorbidity index (CCI), the magnitude of these differences increased up to 3.2% in favour of EBRT in patients aged >75 years with CCI ≥2. In multivariable analysis, rates of 30-, 60- and 90- day mortality were 5.2-, 1.8- and 1.3-fold higher after RP than EBRT, respectively. Our study is limited by its non-randomized design. Conclusion: Overall, absolute short-term mortality rates after RP are comparable to those of EBRT. The difference decreases over time: 90 days <60 days <30 days. Nonetheless, their magnitude is far from trivial in the elderly and sickest patients. (author)
[en] Highlights: • The optimal management strategy for T2MI is unknown. • Troponin positive tachyarrhythmia is not a benign diagnosis. • The mortality rate of troponin positive tachyarrhythmia is similar to NSTEMI. • Formal labeling as T2MI is rare in real life practice. • More investigation into the detection and management of T2MI and troponin positive arrhythmia patients is now warranted. - Abstract: BackgroundThe introduction of the highly sensitive troponin (hs-trop) assays into clinical practice has allowed for the more rapid diagnosis or exclusion of type 1 myocardial infarctions (T1MI) by clinicians, in addition type 2 myocardial infarctions (T2MI) are now more frequently detected. Tachyarrhythmias are one of the common causes of T2MI, the medium and long term outcome for this cohort of T2MI is yet to be clarified.
[en] Prostate cancer is the second most common cause of cancer death in American men. For patients with adverse pathologic features, postoperative radiotherapy to prostate bed after radical prostatectomy has been shown in randomized studies to improve many important clinical endpoints including overall survival. In this review article, we distinguish adjuvant radiation treatment (ART) from salvage radiation treatment (SRT), discuss the evidences for ART and its potential side effects focusing on the debate concerning the optimal timing of post prostatectomy radiation treatment (RT). Material and Method: A comprehensive literature search was conducted in MEDLINE including pre-MEDLINE. Conclusion: for patients with adverse pathologic factors, adjuvant radiation treatment after prostatectomy reduces the rate of PSA failure with the potential for significantly improving metastases-free and overall survival. Whether an equivalent survival benefit can be attained with early salvage radiation treatment after biochemical recurrence, is still an area of debate. (author)
[en] The aim of this study was to determine the effect of five gradient concentrations of cadmium and lead (cadmium sulfate and lead nitrate) on the mortality of common carp fingerlings (Cyprinus carpio), with average weight of 0.49±0.08g and 29.31±1.71g of the AL-sin farm. The results showed that hydrophilic cadmium sulphate had stronger effect on carp fingerling weighing (0.49±0.08g) where the mortality percentage was high by the fourth day of the experiment in the concentration (2.5 mg / L). Lead nitrate had lesser effect on mortality, no where individual has died during the first 3 days. The mortality rate increased in the concentrations (2.5 mg / L) by the sixth day of the experiment. The higher concentrations of cadmium and lead (29.31±1.71g), the cadmium hydroxide sulfate showed stronger effect than the lead nitrate on fish mortality. The mortality rate was high by the fifth day with the concentration (16 mg / L) of Cadmium sulphate, while with the concentration (32 mg / L) of lead nitrate, the mortality rate increased by the seventh day of the experiment. These results indicate that cadmium has stronger toxic effect than lead on the mortality of fish weighing (0.49±0.08g and 29.31±1.71g) with the concentrations and some time periods used during the experiment. (author)
[en] Among the several works based on the classical Kermack–Mckendrick’s SIR (Susceptible–Infected–Removed) epidemiological model, applied to the context of computer viruses propagation, the introduction of antidotal elements has provided the dynamics of the networks when anti-virus programs are used. The SIRA (Susceptible–Infected–Removed–Antidotal) model has shown good qualitative fitness regarding to real operation of the networks, when the mortality rate is considered zero and all the infected nodes being recovered. Here, the SIRA model is studied, considering the mortality rate as a parameter and the conditions for the existence of a disease-free equilibrium state are derived, helping the design of robust networks.
[en] Internal exposure from inhalation of radon and its progeny is one of the most significant sources of natural radiation exposure of the population. Radon levels and radon equilibrium factor were measured in the dwellings of Al-Kharj, Saudi Arabia using passive technique. Calibrated CR-39 diffusion type radon detectors were used for radon measurements and the method of can and bare is adapted for the measurement of radon equilibrium factor. Passive measurements enable the accumulation of the result over a long period and cover a wide area. The probability of cancer induction and then the expected mortality was calculated based on different approaches. The results show that the overall weighted mean of annual effective dose for Al-Kharj resident is equal to 1.51 ± 0.8 mSv and The average expected mortality for residents in dwellings of Al-Kharj city is ranged from 0.596 ± 0.25 to 0.369 ± 0.15 death per 10,000 persons of ages from 40 to 70 years respectively. Also, the lifetime excess absolute risk (LEAR) of the residents of the Al-Kharj city is equal to (2.06 ± 0.8) 104 . The effect of dwelling types, ventilation and construction materials on the expected mortality is discussed
[en] Highlights: • The neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker in different cardiovascular disease as acute myocardial infarction (AMI). • In both STEMI and NSTEMI patients, the SYNTAX score (SXs) correlates with NLR calculated at admission. • NLR is an independent predictor of 1-year CV mortality in patients with STEMI or NSTEMI treated with PCI within 24-h. - Abstract: Background/purposeThe neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker in acute myocardial infarction (AMI). The aim of our study is to demonstrates the correlation between SYNTAX score (SXs) and NLR and its association with 1-year cardiovascular (CV) mortality in patients with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI).
[en] Highlights: • Plastic debris collar wrappings (PDCW) are involved in the frequent entanglement of several groups of marine animals. • We present records for four species afflicted by plastic debris collars. • PDCW reduced fish swimming performances, feeding and antipredator behavior. • Given the importance of these performances on survival, reduction in fitness is expected. - Abstract: Plastic debris collar wrappings (PDCW) are involved in the frequent entanglement of several groups of marine animals. In fishes, however aside from ‘ghost fishing’, PDCW events are rarely documented, and no record of this occurrence exists in tropical reef fishes. Here, we present records for four species afflicted by plastic debris collars. Observations occurred during snorkeling, and included the silver mojarra Eucinostomus argenteus, Atlantic thread herring Ophistonema oglinum, tomtate grunt Haemulon aurolineatum and gray parrotfish Sparisoma axillare. While PDCW may not create an instantaneous source of mortality, our observations suggest that debilitating stress, created by reduced swimming performances, feeding and/or antipredator behavior are likely consequences for afflicted individuals. Given the importance of these performances on survival, reduction in fitness is expected. This note aims to report cases of PDCW and underscore that such interactions between fishes and plastic pollution may be more prevalent than previously expected in coastal reef habitats.