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[en] The possibility of particle track membranes use in hospital treatment of burns have been discussed. The introductory research with patients having different types of skin imitation has been conducted. All tests with PTM dressing have given positive results. 4 tabs
[en] The author introduces a new practical air-seeping and germ-prevention packing container made with a combination of the 0.1-0.5 μm borediameter nuclear track microhole membrane (NTMM) and the PE food wrapper or other poisonous less PE containers of different shapes. It can be applied in the field of food preservation, especially for storage of fresh fruits through irradiation, to achieve breathing with oxygen, and thus to prolong the storage duration
[en] The authors present the results of a year-long survey of the indoor radon concentration levels in the FYR of Macedonia. A total number of 437 dwellings in eight statistical regions were subject to radon concentration measurements by using CR-39 track detectors. The annual mean indoor radon concentration in each measuring site was estimated from the four individual measurements with 3 months duration. The measuring period was from December 2008 to December 2009. The distribution of the results was nearly log-normal. The arithmetic and geometric mean values of the annual mean value of radon concentration were estimated to be 105±84 and 84*/1.9 Bq m-3, respectively. The annual effective dose due to indoor exposure to radon in the dwellings was estimated to be 2.1*/1.9 mSv y-1. (authors)
[en] The one-atom detection technique has been used to search for atoms which are created from the neutralization of heavy ions as they lose their energy in a gas. When Cf-252 decays by binary fission, Cs sup(n+) ions are formed approximately 14% of the time (in the heavy mass peak). Thus, these ions were injected into a gas at a low rate such that the Cs neutral atom could be searched for individually and at a known time after its production. A delay of a few microseconds allowed time for collection of the 3 x 106 electrons created by the 80-MeV Cs sup(n+) energy; then a pulsed laser was fired along each particle track to remove one electron from each Cs atom by the saturated two-step resonance ionization process. These electrons were then drifted into a gas proportional counter and detected individually to measure the probability that a neutral Cs atom would be found at the end of the fission particle track. Our results show that a Cs neutral species is formed about 14% of the time, and thus nearly all Cs sup(n+) ions become Cs0 when the ions are thermalized in P-10 (90% Ar plus 10% CH4) counting gas. Extensions of the technique to obtain other details of particle track structure will be discussed. For example, it is possible to detect even one negative ion created in a track where nearly 100 MeV of energy is absorbed; ant it is likewise possible to determine the population of quantum selected excited states left in the wake of these tracks
[en] Purpose: Investigate capability and accuracy of Kinect v2 camera for tracking respiratory motion to use as a tool during 4DCT or in combination with motion management during radiotherapy treatments. Methods: Utilizing the depth sensor on the Kinect as well as code written in C#, the respiratory motion of a patient was tracked by recording the depth (distance) values obtained at several points on the patient. Respiratory traces were also obtained using Varian’s RPM system, which traces the movement of a propriety marker placed on the patient’s abdomen, as well as an Anzai belt, which utilizes a pressure sensor to track respiratory motion. With the Kinect mounted 60 cm above the patient and pointing straight down, 11 breathing cycles were recorded with each system simultaneously. Relative displacement values during this time period were saved to file. While RPM and the Kinect give displacement values in distance units, the Anzai system has arbitrary units. As such, displacement for all three are displayed relative to the maximum value for the time interval from that system. Additional analysis was performed between RPM and Kinect for absolute displacement values. Results: Analysis of the data from all three systems indicates the relative motion obtained from the Kinect is both accurate and in sync with the data from RPM and Anzai. The absolute displacement data from RPM and Kinect show similar displacement values throughout the acquisition except for the depth obtained from the Kinect during maximum exhalation (largest distance from Kinect). Conclusion: By simply utilizing the depth data of specific points on a patient obtained from the Kinect, respiratory motion can be tracked and visualized with accuracy comparable to that of the Varian RPM and Anzai belt.
[en] Purpose: Registration is one of the key technical components in an image-guided navigation system. A large number of 2D/3D registration algorithms have been previously proposed, but have not been able to transition into clinical practice. The authors identify the primary reason for the lack of adoption with the prerequisite for a sufficiently accurate initial transformation, mean target registration error of about 10 mm or less. In this paper, the authors present two interactive initialization approaches that provide the desired accuracy for x-ray/MR and x-ray/CT registration in the operating room setting. Methods: The authors have developed two interactive registration methods based on visual alignment of a preoperative image, MR, or CT to intraoperative x-rays. In the first approach, the operator uses a gesture based interface to align a volume rendering of the preoperative image to multiple x-rays. The second approach uses a tracked tool available as part of a navigation system. Preoperatively, a virtual replica of the tool is positioned next to the anatomical structures visible in the volumetric data. Intraoperatively, the physical tool is positioned in a similar manner and subsequently used to align a volume rendering to the x-ray images using an augmented reality (AR) approach. Both methods were assessed using three publicly available reference data sets for 2D/3D registration evaluation. Results: In the authors' experiments, the authors show that for x-ray/MR registration, the gesture based method resulted in a mean target registration error (mTRE) of 9.3 ± 5.0 mm with an average interaction time of 146.3 ± 73.0 s, and the AR-based method had mTREs of 7.2 ± 3.2 mm with interaction times of 44 ± 32 s. For x-ray/CT registration, the gesture based method resulted in a mTRE of 7.4 ± 5.0 mm with an average interaction time of 132.1 ± 66.4 s, and the AR-based method had mTREs of 8.3 ± 5.0 mm with interaction times of 58 ± 52 s. Conclusions: Based on the authors' evaluation, the authors conclude that the registration approaches are sufficiently accurate for initializing 2D/3D registration in the OR setting, both when a tracking system is not in use (gesture based approach), and when a tracking system is already in use (AR based approach)
[en] The adenovirus E4-ORF3 protein promotes viral replication by relocalizing cellular proteins into nuclear track structures, interfering with potential anti-viral activities. E4-ORF3 targets transcriptional intermediary factor 1 alpha (TIF1α), but not homologous TIF1β. Here, we introduce TIF1γ as a novel E4-ORF3-interacting partner. E4-ORF3 relocalizes endogenous TIF1γ in virus-infected cells in vivo and binds to TIF1γ in vitro. We used the homologous nature, yet differing binding capabilities, of these proteins to study how E4-ORF3 targets proteins for track localization. We mapped the ability of E4-ORF3 to interact with specific TIF1 subdomains, demonstrating that E4-ORF3 interacts with the Coiled-Coil domains of TIF1α, TIF1β, and TIF1γ, and that the C-terminal half of TIF1β interferes with this interaction. The results of E4-ORF3-directed TIF1 protein relocalization assays performed in vivo were verified using coimmunoprecipitation assays in vitro. These results suggest that E4-ORF3 targets proteins for relocalization through a loosely homologous sequence dependent on accessibility.