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[en] We introduce a new kind of random stationary, scalar beam named Laguerre-cosine-Gaussian correlated Schell-model (LcGCSM) beam whose spectral degree of coherence (SDOC) is a Gaussian function modulated by both non-conventional Laguerre- and cosine-type factors. The analytical expressions for the cross-spectral density of a LcGCSM beam propagating through a paraxial ABCD optical system are derived. The intensity distributions of such beams focused through a thin lens are illustrated numerically. It is found that a LcGCSM beam exhibits self-splitting and self-shaping properties during propagation, evolving into multiple optical cages near the focal region. By directly modulating the spatial structure of the SDOC in the source plane, the characteristics of the optical cages derived from the proposed LcGCSM beams can be adjusted flexibly. Moreover, we demonstrate that these nontrivial focusing properties of a LcGCSM beam can be well elucidated with the combination effect of individual merits associated with each non-conventional SDOC component of the entire SDOC. Therefore, our results provide a new route for generating and controlling multiple optical cages, and will be useful for trapping multiple particles, guiding multiple atoms and optical communications. (paper)
[en] Nanostructured ZnO–Co and ZnO films with Pt, Cu, and Co as top electrodes, and Pt as bottom electrodes were grown by magnetron sputtering. Both ZnO–Co and ZnO films show bipolar resistive switching characteristics. The resistive switching properties of ZnO films are strongly dependent on the top electrode materials. The effect of top electrodes on resistive switching of ZnO–Co films is weakened due to the dominant roles of Co particles in the films. It is different with ZnO films that the ZnO–Co film shows a forming-free process. The calculation from the classical electromagnetism theory indicates that the existence of Co nanoparticles in the ZnO switching matrix can enhance the local electrical field to some extent, and decrease the operating voltages. So the device with a ZnO–Co film as a switching matrix can significantly reduce power consumption, weaken the dependence of the electrode materials, and optimize the resistive switching performance. (paper)
[en] Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis. However, the relationship between exosomal lncRNAs and the diagnosis and prognosis of NSCLC was poorly understood. The aim of this study is to evaluate the clinical significance of serum exosomal MALAT-1 as a biomarker in the metastasis of NSCLC. In this study, we firstly isolated the exosomes from healthy subjects and NSCLC patients. Then we measured the expression levels of MALAT-1 contained in exosomes, and found that exosomal MALAT-1 was highly expressed in NSCLC patients, more importantly, the levels of exosomal MALAT-1 were positively associated with tumor stage and lymphatic metastasis. In addition, we decreased MALAT-1 expression by short hairpin RNA and conducted a series of assays including MTT, cell cycle, colony formation, wound-healing scratch and Annexin/V PI by flow cytometry in human lung cancer cell lines. These in vitro studies demonstrated that serum exosome-derived long noncoding RNA MALAT-1 promoted the tumor growth and migration, and prevented tumor cells from apoptosis in lung cancer cell lines. Taken together, this study shed a light on utilizing MALAT-1 in exosomes as a non-invasive serum-based tumor biomarker for diagnosis and prognosis of NSCLC. - Highlights: • serum MALAT-1 contained in exosomes is upregulated in NSCLC patients. • Exosomal MALAT-1 was positively associated with TNM stage and lymphatic node metastasis. • MALAT-1 knockdown inhibited cell proliferation, colony formation and cell migration. • MALAT-1 knockdown induced cell cycle arrest and cell apoptosis.
[en] MicroRNAs (miRNAs) have a great effect on regulating tumor cell migration, invasion, proliferation and prognosis. However, the mechanism of miR-1236-3p on regulating carcinogenesis is still unknown. In this study, the expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue. In lung adenocarcinoma A549 cell line, miR-1236-3p decreased ability of cell invasion and migration, furthermore, we show that KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8. Additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes. Overexpression of KLF8 can promote EMT-related genes at protein level. In conclusion, our results support the fact that miR-1236-3p acts as a tumor inhibitor in lung adenocarcinoma by suppressing the activity of KLF8, and it may play a critical role in the diagnosis and treatment of lung cancer.
[en] Highlights: •Bi2O3/TiO2 NTAs was fabricated through electrodeposition process. •Bi2O3/TiO2 NTAs performed strong light absorbance and high charge separation. •Bi2O3/TiO2 NTAs exhibited high PC activity for degradation of 4-CP. •The enhanced visible PC mechanism of Bi2O3/TiO2 NTAs was proposed. •Bi2O3/TiO2 NTAs displayed good reusability and stability. -- Abstract: In order to improve the photocatalytic (PC) performance of TiO2 nano-material, TiO2 nanotube arrays (NTAs) was fabricated by anodization. Subsequently, Bi2O3 nano-particles were successfully deposited onto the surface of TiO2 NTAs through galvanostatic electrodeposition strategy. Afterwards, series of characterizations including scanning electron microscope (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS) and photoelectrochemical (PECH) measurements were applied to clarify physicochemical properties of the as-fabricated Bi2O3/TiO2 NTAs photoelectrode. All results indicated that the light absorbance and photoinduced charge separation efficiency of Bi2O3/TiO2 NTAs photoelectrode were significantly improved. As expected, Bi2O3/TiO2 NTAs photoelectrode displayed higher PC efficiency for degradation of 4-chlorphenol (4-CP) aqueous solution than that of pristine TiO2 NTAs. Besides these, the enhanced visible light PC mechanism was proposed. Furthermore, Bi2O3/TiO2 NTAs photoelectrode performed good reusability and stability even after six recycle utilization.