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[en] A new detector which measures position and intensity of 2-dimensional distributions of ionizing radiation from radioisotope labelled TLC-plates, electrophorese gels or any surface distribution of ionizing radiation, i.e. protein distributions, blots, DNA-sequences, tissue sections. The detector is a position sensitive multiwire proportional chamber (MWPC) of 20x20 cm sensitive area detecting with very high sensitivity and high spatial resolution compounds labelled with 3-H, 125-I, 14-C, 32-P, Tc-99m etc. (author). 1 ref.; 14 figs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; 
; 1989; p. 315-321; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 315-321; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] Some recent synthetic aspects of cyclotron-produced organic tracers and their applications in emission tomography (PET and SPECT) are outlined. Special emphasis is given to halogen analogue tracers and the pharmacological applications of PET. (author). 27 refs.; 4 figs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 7-12; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 7-12; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] Conventional and new prospects on polypeptide 3H-labellings studied in our laboratory are reviewed. Particular emphasis is given on the specific labelling of various residues: an important strategy for metabolism studies. (author). 16 refs.; 1 fig
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 67-72; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 67-72; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] The availability of specifically labeled organic compounds is important in the performance of a variety of chemical, biological, and medical studies. In recent years, the development of organometallic reagents has contributed substantially to the preparation of labeled compounds that were previously inaccessible. The versatility provided by organotin reagents, both in their synthesis and transformation, make these reagents among the more valuable for the labeling of aryl and alkenyl moieties. (author). 46 refs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 275-281; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 275-281; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] Organoboranes have proven to be effective precursors for the incorporation of isotopically labeled compounds. Their value rests on the fact that they are reactive intermediates which tolerate variety of functional groups. Thus the isotopes of interest can be incorporated in the final synthetic step which maximizes the yields of desired product. (author). 34 refs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 283-288; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988; CONTRACT DE-FG05-86ER-60434
; 1989; p. 283-288; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988; CONTRACT DE-FG05-86ER-60434
[en] In this paper the authors make certain general observations and comments concerning the role of photosynthesis in the labeling of natural compounds, as well as some recommendations based on recent results regarding the labeling of a new anti-malaria drug extracted from a plant and originally known to traditional Chinese medicine. (author). 6 refs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 471-474; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 471-474; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] Large quantities of single optically active amino acids specifically labelled with carbon-14 are best prepared by a classical racemic chemical synthesis followed by resolution using commercially available enzymes. The ease and reproducibility of the enzyme chemistry has led us to look for other uses of specific enzymes in carbon-14 synthesis. (author)
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 423-426; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 423-426; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] Results of chromatomass-spectrometry of the TMS-derivatives of amino acids, yielded in the reaction of solid-state isotopic exchange with gaseous deuterium is reported. Isotopic effects in sorption of di-TMS-derivatives with different degree of isotopic substitution are 12 joules per introduced atom of deuterium. (author). 2 tabs
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 751-753; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 751-753; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] A special type of Raney nickel can be used for tritium labelling of organic compounds at specific positions and with high specific activities. This catalyst is especially suitable for the replacement of sulphur by tritium and for the hydrogenation of carbonyl moities using tritium. Some examples show that according to this approach specific activities from 4 Ci/mmol to 15 Ci/mmol can be obtained. (author). 2 refs.; 1 tab
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 521-524; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
; 1989; p. 521-524; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988
[en] The facilities and projects of the National Tritium Labeling facility are described. (author). 5 refs.; 1 fig.; 1 tab
Source
Baille, T.A. (Washington Univ., Seattle, WA (USA). Dept. of Medicinal Chemistry); Jones, J.R. (Surrey Univ., Guildford (UK). Dept. of Chemistry) (eds.); 860 p; ISBN 0-444-87368-6; ; 1989; p. 541-544; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988; GRANT P41 RR01237-06; CONTRACT DE-AC03-76SF00098; Supported by the Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, and by the Department of Energy.
; 1989; p. 541-544; Elsevier; Amsterdam (Netherlands); International symposium on the synthesis and applications of isotopically labelled compounds; Innsbruck (Austria); 17-21 Jul 1988; GRANT P41 RR01237-06; CONTRACT DE-AC03-76SF00098; Supported by the Biotechnology Resources Program, Division of Research Resources, National Institutes of Health, and by the Department of Energy.
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