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Raddf, M.Y.
Mosul Univ. (Iraq). Dept. of Chemistry; Mosul Univ. (Iraq). Coll. of Science1990
Mosul Univ. (Iraq). Dept. of Chemistry; Mosul Univ. (Iraq). Coll. of Science1990
AbstractAbstract
[en] This work involve deals with experimental part, deals with methods and the ways used in the synthesis of 3- aryl phthalides startingfrom phthalal aldehydic acid and many phenoles and anisols containing electron with drawing groups such as (CO2H, COR, CHO, NO2), and some of the reactions that started with compounds prepared previously. (15 tabs., 12 figs., 47 refs.)
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Source
1990; 121 p; Available from Information Center-Iraqi Atomic Energy Commission, Tuwaitha-Baghdad, P.O.BOX 765, IRAQ; Thesis (M.Sc.).
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Miscellaneous
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Thesis/Dissertation
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Gao, Fumei; Hu, Wenxin; Li, Yu; Shen, Huan; Hu, Jianying, E-mail: hujy@urban.pku.edu.cn2017
AbstractAbstract
[en] Concerns over the adverse reproductive outcomes in human have been raised, more evidence including the underlying mechanism are required. Since extravillous trophoblast (EVT) invasion is an important physiological step during early development, the effects of mono-2-ethylhexyl phthalate (MEHP), the bioactive metabolite of DEHP, on EVT invasion were investigated using Matrigel-coated transwell chambers and cell line HTR-8/SVneo. In the transwell-based invasive assay, MEHP exposure inhibited EVT invasion as judged by decreased invasion index. Further analysis showed that MEHP exposure significantly inhibited the activity of matrix metalloproteinase-9 (MMP-9), which is an important positive regulator of EVT invasion. Meanwhile, the protein levels of tissue inhibitor matrix metalloproteinase-1 (TIMP-1), one key negative regulator of EVT invasion, were upregulated by MEHP treatment. Finally, inactivation of PPARγ pathway by either PPARγ inhibitors or PPARγ shRNA knockdown rescued the MEHP-induced inhibited invasion of HTR-8/SVneo cells, which is accompanied by the recovery of inhibited MMP-9 expression. The present study provides the evidence that MEHP exposure inhibits trophoblast invasion via PPARγ at concentrations comparable to those found in humans, which provides an insight in understanding the mechanisms of DEHP-associated early pregnancy loss. - Highlights: • MEHP inhibits HTR-8/SVneo cell invasion. • MEHP exposure imbalanced the expression of MMP-9/TIMP-1 in HTR-8/SVneo cells. • This effect of MEHP is mediated via the PPARγ pathway.
Primary Subject
Source
S0041-008X(17)30163-1; Available from http://dx.doi.org/10.1016/j.taap.2017.04.014; Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
[en] A faster, simpler and sensitive method was developed for determination of aliphatic phthalates using differential pulse polarography (DPP) as standard technique. The choice and concentration of base electrolyte, solvent, initial potential, effect of water addition and interference by other phthalates were the main parameters to optimize for enhancement of peak current and to obtain well-defined polarograms with lower background current using 1.3 x 10/sup -4/ M di-butyl phthalate (DBP) solution. Best results were obtained in the presence of tetra methyl ammonium bromide (TMAB) as electrolyte in methanol solvent with initial potential, -1.4 V. A linear calibration plot was observed in the range of 3 x 10/sup -7/ - 1.6 x 10/sup -4/ M DBP solution as aliphatic phthalates with lower detection limit of 5.9 x 10/sup -8/ M and linear regression coefficient of 0.9987. The developed polarographic method was successfully applied for analysis of aliphatic phthalates in various samples of locally available polymer products such as baby toys, nipples, teethers, infusion blood bags and shopping bags. The results of the current method were compared with those obtained by a reported method and good agreement was found between them. (author)
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Journal Article
Journal
Pakistan Journal of Analytical and Environmental Chemistry; ISSN 1996-918X;
; v. 11(1); p. 66-72

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AbstractAbstract
[en] As its widely opening and easy performance, Modbus communication protocol has a great advantage in field bus using. Details are given on a method to implement Modbus communication protocol based on MCS51 system, and the advantage of uVision integrated environment. The design realizes Modbus RTU mode communication, meanwhile the problem of synchronization in communication is solved. And float-point operation and display are achieved by format print. All of this are carried out under uVision integrated environment. The result approves that the response ratio of Modbus communication is 100%. The design shows the advantage of uVision integrated environment and MCS51 system. And also gives solution to the occasion where communication interface and low cost are required. (authors)
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Secondary Subject
Source
2 figs., 2 tabs., 7 refs.
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Journal Article
Journal
Nuclear Electronics and Detection Technology; ISSN 0258-0934;
; v. 30(12); p. 1560-1564

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AbstractAbstract
No abstract available
Original Title
Anizotropiya nelinejnogo pokazatelya prelomleniya v kristallakh biftalatov shchelochnykh metallov; Alkali metals: K, Rb, Cs
Primary Subject
Source
For English translation see the journal Sov. Phys. - Crystallogr.
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Journal Article
Journal
Kristallografiya; v. 19(6); p. 1209-1212
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AbstractAbstract
[en] Citrate synthase from the thermophilic euryarchaeon T. acidophilum fused to a hexahistidine tag was purified and biochemically characterized. The structure of the unliganded enzyme at 2.2 Å resolution contains tail–active site contacts in half of the active sites. Citrate synthase (CS) plays a central metabolic role in aerobes and many other organisms. The CS reaction comprises two half-reactions: a Claisen aldol condensation of acetyl-CoA (AcCoA) and oxaloacetate (OAA) that forms citryl-CoA (CitCoA), and CitCoA hydrolysis. Protein conformational changes that ‘close’ the active site play an important role in the assembly of a catalytically competent condensation active site. CS from the thermoacidophile Thermoplasma acidophilum (TpCS) possesses an endogenous Trp fluorophore that can be used to monitor the condensation reaction. The 2.2 Å resolution crystal structure of TpCS fused to a C-terminal hexahistidine tag (TpCSH6) reported here is an ‘open’ structure that, when compared with several liganded TpCS structures, helps to define a complete path for active-site closure. One active site in each dimer binds a neighboring His tag, the first nonsubstrate ligand known to occupy both the AcCoA and OAA binding sites. Solution data collectively suggest that this fortuitous interaction is stabilized by the crystalline lattice. As a polar but almost neutral ligand, the active site–tail interaction provides a new starting point for the design of bisubstrate-analog inhibitors of CS
Source
Available from http://dx.doi.org/10.1107/S2053230X15015939; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601594; PMCID: PMC4601594; PMID: 26457521; PUBLISHER-ID: ub5080; PUBLISHER-ID: S2053230X15015939; OAI: oai:pubmedcentral.nih.gov:4601594; Copyright (c) Murphy et al. 2015; This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Acta Crystallographica. Section F, Structural Biology Communications; ISSN 2053-230X;
; CODEN ACSFEN; v. 71(Pt 10); p. 1292-1299

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Donon, Jeremy
Universite de Paris-Saclay, Espace Technologique/Immeuble Discovery, Route de l'Orme aux Merisiers RD 128/91190 Saint-Aubin (France); CEA, DRF-IRAMIS (France)2020
Universite de Paris-Saclay, Espace Technologique/Immeuble Discovery, Route de l'Orme aux Merisiers RD 128/91190 Saint-Aubin (France); CEA, DRF-IRAMIS (France)2020
AbstractAbstract
[en] Ion pairs are ubiquitous in nature, from sea water, aerosols, to living organisms. They influence the properties of concentrated ion solutions, and thus play a crucial role in various chemical reactions and biological processes. However, the characterization of ion pairs faces some difficulties: on one hand, several types of pairs coexist, and on the other hand, they are transient species in solution. In this context, this work presents several studies carried out according to three main research studies, backed by an original approach in the gas phase, and then in solution. Firstly, the effects of the electric field produced by the ion pair on the UV spectroscopy of a chromophore in gas phase (Stark effects) are studied. The ion groups can produce an electric field high enough to induce significant electronic Stark effects on a nearby UV chromophore. This study is conducted on model systems (C6H5-(CH2)n-COO-,M+) with M = Li, Na, K, Rb, Cs and n = 1-3, allowing to vary the electric field experienced by the UV chromophore. These different systems are studied in the gas phase by UV spectroscopy combined with quantum chemistry calculations, as well as by conformation selective IR spectroscopy. Based on the analysis of the electronic Stark effects, precise conformational assignments can be proposed for electronic transitions separated by a few cm-1, without resorting to IR spectroscopy, or frequency calculations. The next study is focused mainly on understanding the environmental effects on ion pairs by microsolvation experiments in gas phase. The pair of sodium acetate ions [CH3-COO-,Na+] is studied for the first time in a trimer complex with p-xylene by IR spectroscopy. Micro-hydration experiments are then carried out on charged ion pairs ([CH3-COO-,M2+]; M = Ca, Ba), highlighting two different behaviours depending on the nature of the cation. The final research is to detect and identify the structures formed by the ions in electrolytic solutions by IR and RX spectroscopy. The first experiment is carried out on electrolytic solutions ([CH3-COO-,M+]; M = Li, Na and K) by TF-IR spectroscopy by varying the ion concentration. A theoretical study is then carried out in order to propose a theoretical spectrum for each type of pair, and to confront them with experimental spectra in solution. The approach is based on the calculation of the IR signature of pairs ([CH3-COO-,M+]; M = Li, Na, K, Rb and Cs) and free anion in solution, where the first solvation layer were described at the quantum level, followed by a solvent continuum. For each type of pair, spectroscopic families, consistent with the experimental data, are identified. This original approach paves way to the identification of supramolecular structures in electrolytic solutions. Finally, the first FZRET experiment in liquid micro-jet is carried out on a potassium acetate solution, providing access to a measurement of the distance distribution between cations and paired anions.In these studies, different methods are used ranging from experiment to theory, from the gas phase to solution. This work illustrates the need to combine several methods in order to obtain additional data and allow a better characterization of the supramolecular organisation of ions and their environment. (author)
[fr]
Les paires d'ions sont omnipresentes dans la nature, depuis l'eau de mer, les aerosols, jusqu'aux organismes vivants. Elles influencent les proprietes des solutions concentrees en ions, et jouent ainsi un role majeur dans divers reactions chimiques et processus biologiques. Cependant, la caracterisation des paires d'ions se heurte a une double difficulte: d'une part, plusieurs types de paires coexistent, et d'autre part, ce sont des especes transitoires en solution. Dans ce contexte, ce travail presente plusieurs etudes menees selon trois axes de recherche principaux grace a une approche originale en phase gazeuse, puis en solution. Le premier axe consiste a etudier les effets du champ electrique produit par la paire d'ions sur la spectroscopie d'un chromophore UV en phase gazeuse (effets Stark). Les groupes ioniques sont capables de produire un champ electrique suffisamment eleve pour induire des effets Stark electroniques significatifs sur un chromophore UV situe a proximite. Cette etude est menee sur des systemes modeles de formule generale (C6H5-(CH2)n-COO-,M+) avec M = Li, Na, K, Rb, Cs et n = 1-3, permettant de faire varier le champ electrique ressenti par le chromophore UV. Ces differents systemes sont etudies en phase gazeuse par spectroscopie UV combinee a des calculs de chimie quantique, ainsi que par des experiences de spectroscopie IR selective en conformation. Grace a cette approche, des attributions conformationnelles precises peuvent etre proposees pour des transitions electroniques separees de quelques cm-1, sur la base de l'analyse des effets Stark observes sur le spectre UV, sans recourir a la spectroscopie IR, ni aux calculs de frequences. Il s'agit ensuite de comprendre les effets d'environnement sur les paires d'ions par des experiences de microsolvatation en phase gazeuse. La paire d'ions d'acetate de sodium [CH3-COO-,Na+] est etudiee pour la premiere fois dans un complexe trimere avec le p-xylene par spectroscopie IR. Des experiences de microhydratation sont ensuite realisees sur des paires d'ions chargees ([CH3-COO-,M2+]; M = Ca, Ba), mettant en evidence deux comportements differents en fonction de la nature du dication. Les differentes experiences montrent que la signature IR du groupement carboxylate est sensible a son environnement proche, mais egalement a l'environnement du cation qui lui est apparie. Le dernier axe consiste a detecter et identifier les structures formees par les ions dans les solutions electrolytiques par spectroscopies IR et RX. Une premiere analyse est effectuee sur des solutions electrolytiques ([CH3-COO-,M+]; M = Li, Na et K) par spectroscopie IR-TF en variant la concentration en ions. Une etude theorique est ensuite realisee dans l'objectif de proposer un spectre theorique pour chaque type de paires, et de les confronter aux spectres experimentaux en solution. L'approche repose sur le calcul de la signature IR de paires ([CH3-COO-,M+]; M = Li, Na, K, Rb et Cs) et de l'anion libre, entoures successivement de molecules d'eau explicites decrites au niveau chimie quantique, puis au niveau champ de force et enfin par un modele de solvant continu. Pour chaque type de paires, des familles spectroscopiques compatibles avec les donnees experimentales sont identifiees. Cette approche originale ouvre la voie vers l'identification des structures supramoleculaires dans les solutions electrolytiques. Enfin, la premiere experience FZRET en micro-jet liquide est realisee sur une solution d'acetate de potassium, donnant acces a une mesure de la distribution des distances entre cations et anions apparies. Au cours de ces etudes, differentes methodes sont employees allant de l'experience a la theorie, de la phase gazeuse a la solution. Cette these illustre la necessite de combiner plusieurs methodes afin d'obtenir des donnees complementaires permettant une meilleure caracterisation de l'organisation supramoleculaire des ions et de leur environnementOriginal Title
Caracterisation de paires d'ions par spectroscopies IR, UV et rayons X, interpretees par calculs de chimie quantique
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2 Jul 2020; 281 p; 161 refs.; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses; Chimie
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Report
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AbstractAbstract
[en] Purpose: In order to receive DICOM files from treatment planning system and generate patient isocenter positioning parameter file for CT laser system automatically, this paper presents a method for communication with treatment planning system and calculation of isocenter parameter for each radiation field. Methods: Coordinate transformation and laser positioning file formats were analyzed, isocenter parameter was calculated via data from DICOM CT Data and DICOM RTPLAN file. An in-house software-DicomGenie was developed based on the object-oriented program platform-Qt with DCMTK SDK (Germany OFFIS company DICOM SDK) . DicomGenie was tested for accuracy using Philips CT simulation plan system (Tumor LOC, Philips) and A2J CT positioning laser system (Thorigny Sur Marne, France). Results: DicomGenie successfully established DICOM communication between treatment planning system, DICOM files were received by DicomGenie and patient laser isocenter information was generated accurately. Patient laser parameter data files can be used for for CT laser system directly. Conclusion: In-house software DicomGenie received and extracted DICOM data, isocenter laser positioning data files were created by DicomGenie and can be use for A2J laser positioning system
Primary Subject
Source
(c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Arnal, Thierry; Ganivet, Michel; Somon, Roland.
CEA, 75 - Paris (France)1971
CEA, 75 - Paris (France)1971
AbstractAbstract
No abstract available
Original Title
Installation de sechage de substances radioactives
Primary Subject
Source
26 Jul 1971; 9 p; FR PATENT DOCUMENT 2,067,851; French patent 69.39746. Filing date: 19 Nov 1969.
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Patent
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AbstractAbstract
[en] An approach to managing diagnostic data in heterogenous formats by using XML-based (eXtensible Markup Language) tag files is discussed. The tag file functions like header information in ordinary data formats but it is separate from the main body of data, human readable, and self-descriptive. Thus all the necessary information for reading the contents of data can be obtained without prior information or reading the data body itself. In this paper, modeling of diagnostic data and its representation in XML are studied and a very primitive implementation of this approach in C++ is presented. The overhead of manipulating XML in a proof-of-principle code was found to be small. The merits, demerits, and possible extensions of this approach are also discussed.
Primary Subject
Source
7. IAEA technical meeting on control, data acquisition and remote participation for fusion research; Aix-en-Provence (France); 15-19 Jun 2009; S0920-3796(10)00017-7; Available from http://dx.doi.org/10.1016/j.fusengdes.2010.01.016; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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