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AbstractAbstract
[en] The present study was undertaken to examine the effect of marrow preservation at 4 degrees C on subsequent long-term culture, which evaluates both hematopoietic precursor cells and hematopoietic microenvironmental cells. Storage of unfractionated marrow was superior to storage of buffy-coat cells in tissue culture medium with 20% fetal calf serum. CFU-C recovery in unfractionated marrow was 48.4% at four days and 21.4% at seven days. Long-term marrow cultures from cells stored at 4 degrees C for up to seven days produced CFU-C for up to seven weeks and established confluent marrow stromal cell layers. Suspension cultures of marrow cells preserved at 4 degrees C for seven days cultured with irradiated allogeneic marrow stromal cell layers from normal long-term marrow cultures showed significantly increased CFU-C production from week 2 to week 5 when compared with the control cultures without adherent cell layers. These data suggest that marrow storage at 4 degrees C for up to seven days preserves early hematopoietic precursor cells and microenvironmental cells and may be used for autologous rescue from marrow ablative therapy
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AbstractAbstract
[en] Abstract only
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Source
Australian Inst. of Nuclear Science and Engineering, Lucas Heights (Australia); 54 p; 1987; p. 37; 11. AINSE radiation biology conference; Lucas Heights (Australia); 24-25 Aug 1987
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Miscellaneous
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AbstractAbstract
[en] Radiosensitivity of spleen CFU depositing in bone marrow and in the spleen does not differ essentially. For CFU forming colonies in the spleen the Dsub(o) value varies within 105-120 R. For CFU forming colonies in bone marrow the value of Dsub(o) is 120-135 0. It is suggested that in bone marrow there are 2 fractions of CFU one of which is radiosensitive and the other radioresistant. It is mainly radiosensitive fraction of CFU that is localized, in the spleen
Original Title
Radiochuvstvitel'nost' i napravlenie differentsirovki kolonieobrazuyushchikh kletok selezenki
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For English translation see the journal Bull. Exp. Biol. Med.
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Journal Article
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Byulleten' Ehksperimental'noj Biologii i Meditsiny; v. 81(1); p. 74-76
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AbstractAbstract
No abstract available
Original Title
Analise critica dos modelos de calculo de dose absorvida nos tecidos radiossensiveis dos ossos
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34. Annual Meeting of the Brazilian Society for the Advancement of Science; Campinas, SP (Brazil); 6-14 Jul 1982; Published in summary form only.
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Cienc. Cult. (Sao Paulo) Supl; v. 34(7); p. 247
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AbstractAbstract
[en] Short note
Original Title
Primenenie mechenykh liposom dlya vizualizatsii kostnogo mozga
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12. All-union conference of roentgenologists and radiologists; Leningrad (USSR); 15-17 Nov 1990
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Wang Hengjian; Liu Guangpeng; Zhou Guangdong; Cen Lian; Cui Lei; Cao Yilin, E-mail: cuileite@yahoo.com.cn, E-mail: yilincao@yahoo.com2010
AbstractAbstract
[en] Preservation of tissue-engineered (TE) bone is one of the key problems needed to be solved for its clinic application and industrialization. Traditional cryopreservation has been restricted because of the damages caused by ice formation and solution. Hypothermic preservation at 4 0C has been widely used for the preservation of transplanted organ despite potential negative effects on viability of cells and tissue. 37 0C is the best temperature for maintaining cellular bioactivities. However, 37 0C also has a potential negative effect on preserved cells due to consumption of nutrients and accumulation of by-products. No studies have reported which temperature is more suitable for the preservation of TE bone constructs. The current study explored the feasibility of preservation of TE bone constructs in sealed osteogenic media at 37 0C and 4 0C. Human bone marrow stromal cells (hBMSCs) were seeded into partially demineralized bone matrix (pDBM) scaffolds and cultured for 7 days to form TE bone constructs. The constructs were preserved in sealed osteogenic media at either 37 0C or 4 0C for 5, 7, 9 and 11 days, respectively. Growth kinetics, viability, metabolism and osteogenic capability were evaluated to explore the feasibility of preservation at 37 0C and 4 0C. The constructs cultured in osteogenic media at humidified 37 0C/5%CO2 served as the positive control. The results demonstrated that all the constructs preserved at 4 0C showed negative osteogenic capability at all time points with a much lower level of growth kinetics, viability and metabolism compared to the positive control. However, the constructs preserved at 37 0C showed good osteogenic capability within 7 days with a certain level of growth kinetics, viability and metabolism, although an obvious decrease in osteogenic capability was observed in the constructs preserved at 37 0C over 9 days. These results indicate that the preservation of TE bone constructs is feasible at 37 0C within 7 days in sealed osteogenic media.
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S1748-6041(10)40877-3; Available from http://dx.doi.org/10.1088/1748-6041/5/3/035010; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Biomedical Materials (Bristol. Online); ISSN 1748-605X;
; v. 5(3); [7 p.]

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No abstract available
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Kaul, A.; Neider, R.; Pensko, J.; Stieve, F.E.; Brunner, H. (eds.); 545 p; ISBN 3-88585-170-9;
; 1984; p. 984-987; Verl. TUEV Rheinland; Koeln (Germany, F.R.); 6. international congress of the International Radiation Protection Association (IRAP-6) and exhibition; Berlin (Germany, F.R.); 7-12 May 1984; CONTRACT W-7405-ENG-26; Published in summary form only.

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Book
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Wang, Sheng-Nan; Zhao, Xing-Qi; Yu, Bin; Wang, Bo-Wei, E-mail: yubinyb22@163.com, E-mail: boweibw21@163.com2018
AbstractAbstract
[en] Highlights: • miR-193a inhibits osteogenic differentiation of hBMSC. • miR-193a attenuates activation of MAPK and Wnt signaling pathway. • miR-193a suppresses osteogenic differentiation partially via HMGB1. • HMGB1 greatly rescues miR-193a-inhibited activation of MAPK and Wnt signaling pathway. miR-193a has been shown to be involved in a variety of biological processes, including cell proliferation, differentiation, and apoptosis. However, little is known about how miR-193a regulates osteogenic differentiation.
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S0006291X18312014; Available from http://dx.doi.org/10.1016/j.bbrc.2018.05.132; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 503(2); p. 536-543

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[en] Published in summary form only
Original Title
Experience em transplante autologo de medula ossea (Tamo) no Hospital Sirio-Libanes - SP (Brasil)
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11. Brazilian Congress of Oncology; Florianopolis, SC (Brazil); Nov 1987
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[en] The probability that bone-marrow transplantation will be beneficial after nuclear accidents depends on several factors, including circumstances of the accident, degree of damage in other body systems, and radiation dose. Transplant-related variables, such as donor-recipient histocompatibility and post-transplant immune suppression, are also important. The benefits of transplantation may result from transient or permanent haemopoietic reconstitution. The balance of potential benefits versus risks should be individually calculated for each accident and each patient; generalisations are likely to result in untenable conclusions. (author)
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