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AbstractAbstract
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13 Jan 1972; 42 p
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Report
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Riklis, E.; Ronen, M.
Israel Atomic Energy Commission, Tel Aviv
Research laboratories annual report 19751976
Israel Atomic Energy Commission, Tel Aviv
Research laboratories annual report 19751976
AbstractAbstract
No abstract available
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Israel Atomic Energy Commission, Tel Aviv; p. 230-231; Jun 1976; In abstract form only.
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Report
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AbstractAbstract
[en] The prognostic significance of HER-2/neu in breast cancer is a matter of controversy. We have performed a study in 101 node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting, and analysed the prognostic significance of immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), both separately and in combination, in comparison with traditional prognostic factors. Overexpression was classified semiquantitatively according to a score (0 to 3+) (HER-2-SCO). FISH was used to analyse HER2/neu amplification (HER-2-AMP). Patients classified 2+ by IHC were examined with FISH for amplification (HER-2-ALG). Patients with 3+ overexpression as well as amplification of HER-2/neu were positive for the combined variable HER2-COM. These variables were compared with tumour size, histological grade and hormone receptor status. HER-2-SCO was 3+ in 20% of all tumours. HER-2-ALG was positive in 22% and amplification (HER-2-AMP) was found in 17% of all tumours. Eleven percent of the tumours showed simultaneous 3+ overexpression and amplification. Only histological grade (relative risk [RR] 3.22, 95% confidence interval [CI] 1.73–5.99, P = 0.0002) and HER-2-AMP (RR 2.47, 95% CI 1.12–5.48, P = 0.026) were significant for disease-free survival in multivariate analysis. For overall survival, both histological grade (RR 3.89, 95% CI 1.77–8.55, P = 0.0007) and HER-2-AMP (RR 3.08, 95% CI 1.24–7.66, P = 0.016) retained their independent significance. The prognostic significance of HER-2/neu in node-negative breast cancer depends on the method of testing: only the amplification of HER-2/neu is an independent prognostic factor for the long-term prognosis of untreated node-negative breast cancer
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Source
Available from http://dx.doi.org/10.1186/bcr991; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064139; PMCID: PMC1064139; PUBLISHER-ID: bcr991; PMID: 15743506; OAI: oai:pubmedcentral.nih.gov:1064139; Copyright (c) 2005 Schmidt et al.; licensee BioMed Central Ltd.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Breast Cancer Research (Print); ISSN 1465-5411;
; v. 7(2); p. 256-266

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AbstractAbstract
No abstract available
Original Title
Patent
Primary Subject
Source
3 Dec 1974; 6 p; US PATENT DOCUMENT 3,852,072
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Patent
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AbstractAbstract
No abstract available
Original Title
Cs. generator india - sup(113m)In
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Source
Ceskoslovenska Spolecnost Nuklearni Mediciny a Radiacni Hygieny; 229 p; 1981; p. 73; 1. congress of Czechoslovak Society for Nuclear Medicine and Radiation Hygiene; Prague (Czechoslovakia); 8-12 Nov 1981; Published in summary form only.
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Miscellaneous
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Meyer, R.A.; Struble, G.L.
California Univ., Livermore (USA). Lawrence Livermore Lab1972
California Univ., Livermore (USA). Lawrence Livermore Lab1972
AbstractAbstract
No abstract available
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Source
5 Jul 1972; 3 p; International conference on nuclear moments and nuclear structure; Osaka, Japan; 4 Sep 1972; CONF-720932--1
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Report
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Conference
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INIS VolumeINIS Volume
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AbstractAbstract
No abstract available
Original Title
Half-life, Q, γ branching
Primary Subject
Source
Macias, E.S.; Washington Univ., St. Louis, Mo. (USA); p. 6-13; 1974
Record Type
Report
Literature Type
Progress Report
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AbstractAbstract
[en] This paper describes a method of preparing 113Sn-sup(113m)In generators using 113Sn of relatively low specific activity (2-3 Ci/g) obtained by irradiation of enriched 112Sn in CIRUS. In this modified procedure, 113SnCl4 is firmly absorbed on hydrous zirconia from 3-4 M NaCl solutions of pH 1.3 to 1.5 and the elution of sup(113m)In is effected by dilute HCl. The generators yields 70% of the theoretically available sup(113m)In activity. 113Sn breakthrough has been consistently less than 0.01% of the sup(113m)In activity. Stable zirconium contamination in the eluate has been estimated to be less than 1 ppm. The performance characteristics of different varieties of hydrous zirconia have been studied to evaluate the optimum tin loading, indium elution and soluble zirconium contamination. Generators containing up to 100 mCi of 113Sn have been prepared yielding pure sup(113m)In suitable for medical use. (author)
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Journal Article
Journal
Isotopenpraxis; v. 11(7); p. 246-249
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Link, R.; Nuding, W.; Sauerwein, K.
Proceedings of the third Working Meeting Radioisotope Application and Radiation Processing in Industry. Vol. 21986
Proceedings of the third Working Meeting Radioisotope Application and Radiation Processing in Industry. Vol. 21986
AbstractAbstract
[en] The application of radioactive tracers in industry often requires the use of short lived isotopes, which can be conveniently produced by isotope generators. Examples for measurements with In-113m are given. (author)
Primary Subject
Source
Akademie der Wissenschaften der DDR, Leipzig. Zentralinstitut fuer Isotopen- und Strahlenforschung; 297 p; 1986; p. 579-584; 3. working meeting on radioisotope application and radiation processing in industry; Leipzig (German Democratic Republic); 23-27 Sep 1985; Available from Central Institute of Isotope and Radiation Research, DDR-7050 Leipzig
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Miscellaneous
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Conference
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AbstractAbstract
[en] The physicochemical behavior of open-quotes hotclose quotes 113mIn impurity atoms during structural transitions in metallic Sn is studied using the shift of secular radioactive equilibrium, secondary-electron Mossbauer spectroscopy, and X-ray phase analysis. The observed anomalies of the impurities, their accelerated migration to regions of low temperature, and emanation into the gas phase at submelting temperatures result from thermally induced reconstructive surface phase transitions
Source
Translated from Radiokhimiya; 36: No. 5, 429-433(Sep-Oct 1994).
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Journal Article
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Translation
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