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[en] The prognostic significance of HER-2/neu in breast cancer is a matter of controversy. We have performed a study in 101 node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting, and analysed the prognostic significance of immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), both separately and in combination, in comparison with traditional prognostic factors. Overexpression was classified semiquantitatively according to a score (0 to 3+) (HER-2-SCO). FISH was used to analyse HER2/neu amplification (HER-2-AMP). Patients classified 2+ by IHC were examined with FISH for amplification (HER-2-ALG). Patients with 3+ overexpression as well as amplification of HER-2/neu were positive for the combined variable HER2-COM. These variables were compared with tumour size, histological grade and hormone receptor status. HER-2-SCO was 3+ in 20% of all tumours. HER-2-ALG was positive in 22% and amplification (HER-2-AMP) was found in 17% of all tumours. Eleven percent of the tumours showed simultaneous 3+ overexpression and amplification. Only histological grade (relative risk [RR] 3.22, 95% confidence interval [CI] 1.73–5.99, P = 0.0002) and HER-2-AMP (RR 2.47, 95% CI 1.12–5.48, P = 0.026) were significant for disease-free survival in multivariate analysis. For overall survival, both histological grade (RR 3.89, 95% CI 1.77–8.55, P = 0.0007) and HER-2-AMP (RR 3.08, 95% CI 1.24–7.66, P = 0.016) retained their independent significance. The prognostic significance of HER-2/neu in node-negative breast cancer depends on the method of testing: only the amplification of HER-2/neu is an independent prognostic factor for the long-term prognosis of untreated node-negative breast cancer

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[en] This paper describes a method of preparing ¹¹³Sn-sup(113m)In generators using ¹¹³Sn of relatively low specific activity (2-3 Ci/g) obtained by irradiation of enriched ¹¹²Sn in CIRUS. In this modified procedure, ¹¹³SnCl₄ is firmly absorbed on hydrous zirconia from 3-4 M NaCl solutions of pH 1.3 to 1.5 and the elution of sup(113m)In is effected by dilute HCl. The generators yields 70% of the theoretically available sup(113m)In activity. ¹¹³Sn breakthrough has been consistently less than 0.01% of the sup(113m)In activity. Stable zirconium contamination in the eluate has been estimated to be less than 1 ppm. The performance characteristics of different varieties of hydrous zirconia have been studied to evaluate the optimum tin loading, indium elution and soluble zirconium contamination. Generators containing up to 100 mCi of ¹¹³Sn have been prepared yielding pure sup(113m)In suitable for medical use. (author)

[en] The Pandya transformation and the Paar parabola rule are used to predict the level structure of particle-hole ¹⁰⁰In from the known levels of particle-particle ⁹²Nb. (Auth.)

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