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[en] The prognostic significance of HER-2/neu in breast cancer is a matter of controversy. We have performed a study in 101 node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting, and analysed the prognostic significance of immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), both separately and in combination, in comparison with traditional prognostic factors. Overexpression was classified semiquantitatively according to a score (0 to 3+) (HER-2-SCO). FISH was used to analyse HER2/neu amplification (HER-2-AMP). Patients classified 2+ by IHC were examined with FISH for amplification (HER-2-ALG). Patients with 3+ overexpression as well as amplification of HER-2/neu were positive for the combined variable HER2-COM. These variables were compared with tumour size, histological grade and hormone receptor status. HER-2-SCO was 3+ in 20% of all tumours. HER-2-ALG was positive in 22% and amplification (HER-2-AMP) was found in 17% of all tumours. Eleven percent of the tumours showed simultaneous 3+ overexpression and amplification. Only histological grade (relative risk [RR] 3.22, 95% confidence interval [CI] 1.73–5.99, P = 0.0002) and HER-2-AMP (RR 2.47, 95% CI 1.12–5.48, P = 0.026) were significant for disease-free survival in multivariate analysis. For overall survival, both histological grade (RR 3.89, 95% CI 1.77–8.55, P = 0.0007) and HER-2-AMP (RR 3.08, 95% CI 1.24–7.66, P = 0.016) retained their independent significance. The prognostic significance of HER-2/neu in node-negative breast cancer depends on the method of testing: only the amplification of HER-2/neu is an independent prognostic factor for the long-term prognosis of untreated node-negative breast cancer

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[en] This paper describes a method of preparing ¹¹³Sn-sup(113m)In generators using ¹¹³Sn of relatively low specific activity (2-3 Ci/g) obtained by irradiation of enriched ¹¹²Sn in CIRUS. In this modified procedure, ¹¹³SnCl₄ is firmly absorbed on hydrous zirconia from 3-4 M NaCl solutions of pH 1.3 to 1.5 and the elution of sup(113m)In is effected by dilute HCl. The generators yields 70% of the theoretically available sup(113m)In activity. ¹¹³Sn breakthrough has been consistently less than 0.01% of the sup(113m)In activity. Stable zirconium contamination in the eluate has been estimated to be less than 1 ppm. The performance characteristics of different varieties of hydrous zirconia have been studied to evaluate the optimum tin loading, indium elution and soluble zirconium contamination. Generators containing up to 100 mCi of ¹¹³Sn have been prepared yielding pure sup(113m)In suitable for medical use. (author)

[en] The application of radioactive tracers in industry often requires the use of short lived isotopes, which can be conveniently produced by isotope generators. Examples for measurements with In-113m are given. (author)

[en] The physicochemical behavior of open-quotes hotclose quotes ^113mIn impurity atoms during structural transitions in metallic Sn is studied using the shift of secular radioactive equilibrium, secondary-electron Mossbauer spectroscopy, and X-ray phase analysis. The observed anomalies of the impurities, their accelerated migration to regions of low temperature, and emanation into the gas phase at submelting temperatures result from thermally induced reconstructive surface phase transitions