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AbstractAbstract
[en] This investigation analyzed the effect of labor on the phagocytic activity of neutrophils in women with uncomplicated term pregnancies. Nineteen healthy women who were not pregnant and did not use oral contraceptives or glucocorticoids served as controls. Peripheral venous blood samples were collected from 15 study patients who were in the active phase of labor (5-10 cm of dilation). Neutrophil phagocytic function was evaluated with the radioiodine fixation test. Assays were conducted utilizing both pooled homologous serum and autologous serum. There was no statistically significant difference in the neutrophil phagocytic function of laboring patients and controls. In addition, there was no evidence that serum from pregnant women exerted a depressant effect on phagocytosis
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Goetz, D.H.; Willie, S.T.; Armen, R.; Bratt, T.; Borregaard, N.; Strong, R.K.
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
AbstractAbstract
No abstract available
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LBNL/ALS--43582; AC03-76SF00098; Available from Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (US); Journal Publication Date: February 29 2000
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AbstractAbstract
[en] Specimens from 27 bone lesions of histiocytosis X were analysed semiquantitatively before treatment. Eosinophilic granulocytes seemed to be the only significant prognostic cell type. Absence of eosionphils or only slight eosinophilia in the initial bone lesions were found predominantly in widespread disease with fatal outcome. A moderate or severe degree of eosinophilia dominated in solitary bone lesions with good prognosis. (Auth.)
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Paper I published in Acta Radiol. Ther. Phys. Biol. 16 (1977) p. 538.
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Journal Article
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Acta Radiol., Oncol., Radiat. Phys., Biol; v. 17(1); p. 10-16
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Goetz, D.H.; Willie, S.T.; Armen, R.; Bratt, T.; Borregaard, N.; Strong, R.K.
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
AbstractAbstract
No abstract available
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Source
LBNL/ALS--43582; AC03-76SF00098; Journal Publication Date: February 29 2000
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Journal Article
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Biochemistry (New York); ISSN 0006-2979;
; v. 39(8); [10 p.]

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AbstractAbstract
[en] We have developed a coculture system which in parallel indicates the sensitizing and irritative potential of xenobiotics. The assay is named loose-fit coculture-based sensitization assay (LCSA) and may be performed within 5 days. The system is composed of human monocytes that differentiate to a kind of dendritic cells by 2-day culturing in the presence of allogenic keratinocytes. The culture medium is enriched by a cocktail of recombinant cytokines. On day 3, concentration series of probes are added. On day 5, cells are harvested and analyzed for expression range of CD86 as a marker of sensitizing potential and for uptake of the viability stain 7-AAD as a marker of irritative potential. Estimation of the concentration required to cause a half-maximal increase in CD86 expression allowed quantification of sensitizing potential, and estimation of the concentration required to reduce viability to 50% allowed quantification of irritative potential. Examination of substances with known potential resulted in categorization of test scores. To evaluate our data, we have compared results with those of the validated animal-based sensitization test, the murine local lymph node assay (LLNA, OECD TG 429). To a large extent, results from LCSA and from LLNA achieved analogous grouping of allergens into categories like weak-moderate-strong. However, the new assay showed an improved capacity to distinguish sensitizers from non-sensitizers and irritants. In conclusion, the LCSA contains potential to fulfil the requirements of the EU's programme for the safety of chemicals 'Registration, Evaluation, Authorisation and Restriction of chemical substances' (REACH, 2006) to replace animal models.
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S0041-008X(10)00088-8; Available from http://dx.doi.org/10.1016/j.taap.2010.02.019; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
[en] Bortezomib, which is a potent proteasome inhibitor, has been used as a first-line drugs to treat multiple myeloma for a few decades, and radiotherapy has frequently been applied to manage acute bone lesions in the patients. Therefore, it was necessary to investigate what the benefits might be if the two therapies were applied simultaneously in the treatment of multiple myeloma. Since it was known that radiotherapy and proteasome inhibitors could increase the expression of NKG2D ligands through induction of protein synthesis and suppression of protein degradation of NKG2D ligands, respectively, we supposed that the combined treatment might further enhance the expression of NKG2D ligands. In this study, we analyzed the expression level of NKG2D ligands using multiplex PCR and flow cytometry after treatment of IM-9 and RPMI-8226 myeloma cells with bortezomib and ionizing radiation; we then assayed the susceptibility to NK-92 cells. Although the expression of only some kinds of NKG2D ligands were increased by treatment with bortezomib alone, five kinds of NKG2D ligands that we assayed were further induced at the surface protein level after combined treatment with ionizing radiation and bortezomib. Furthermore, combined treatment made myeloma cells more susceptible to NK-92 cells, compared with treatment with bortezomib alone. In conclusion, the combination therapy of ionizing radiation plus the proteasome inhibitor bortezomib is a promising therapeutical strategy for enhancing NK cell–mediated anticancer immune responses.
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Available from http://dx.doi.org/10.1093/jrr/rry005; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967576; PMCID: PMC5967576; PMID: 29518205; PUBLISHER-ID: rry005; OAI: oai:pubmedcentral.nih.gov:5967576; Copyright (c) The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Journal of Radiation Research; ISSN 0449-3060;
; v. 59(3); p. 245-252

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Lima, L.D.; MoreiraFilho, R.N.F.; Moraes, A.F.; Vieira, R.S.; Campelo, C.C.O.; Freitas, L.B.; Leal, L.K.A.M, E-mail: rodrigogpsa@gmail.com, E-mail: kalyneleal@gmail.com
Sociedade Latino Americana de Biomateriais e Órgãos Artificiais (SLABO), São Paulo, SP (Brazil)2016
Sociedade Latino Americana de Biomateriais e Órgãos Artificiais (SLABO), São Paulo, SP (Brazil)2016
AbstractAbstract
[en] Alginate is a biopolymer extracted from brown algae intracellular matrix. It is constituted by two monometers: D-mannuronic (M) and L-guluronic (G). It has many interesting properties, such as low toxicity, biocompatibility and biodegradability. The aim of the present study was to characterize the alginate rich in guluronic acid (AGA) and evaluate its effect in human neutrophils. Analyzing the NMR spectra, it was possible to see a considerable separation for alginate polymer blocks (higher G-block content). The neutrophils were incubated with AGA and stimulated by PMA. Myeloperoxidase (MPO) released by cells was used as marker of neutrophil degranulation. The AGA inhibited the neutrophils degranulation induced by PMA, and it was not observed any cytotoxic effects of this alginate in human neutrophils. This work showed the anti-inflammatory activity, without interfering with the cell viability. The chemical and biological characteristics of AGA support its potential use as functional biomaterial for health care. (author)
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2016; 9 p; COLAOB 2016: 9. Latin American congress of artificial organs and biomaterials; Foz do Iguacu, PR (Brazil); 24-27 Aug 2016; SLABO 2016: 13. congress of the Latin American Society of biomaterials, artificial organs and tissue engineering; Foz do Iguacu, PR (Brazil); 24-27 Aug 2016
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Miscellaneous
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AbstractAbstract
[en] Neutropenia and infections are the most restrictive side effects during chemotherapy application. The granulocytic colonies stimulating factor activates the neutrophils, shortens the neutropenic period and can be effective against the potential risk of infection. The purpose of this study was to evaluate the efficacy and safety of LeukoCIM (CIMAB, Havana). A retrospective observational study was carried out with data from the patients with neutropenic episodes enrolled in the open-label, non-randomized, multicenter, phase IV clinical trial. These patients were from Gustavo Aldereguia Lima hospital. They had been evaluated for one year. Demographic information, clinical data and side effects were analyzed. As prophylaxis indication LeukoCIM was administrated 24-72 h after the last chemotherapy dose and as treatment when neutropenia was diagnosed. In both cases, a daily single 300 μg dose was administrated subcutaneously. The application of the next chemotherapy cycle on time was the main variable of response and the product safety was assessed by measuring the side effects. Forty seven patients with 95 neutropenic episodes were enrolled. The 82.1 % of episodes received their next chemotherapy cycle on time. The most frequent side effects were: bone pain and fever (11.2 % respectively), hyperuricemia (9.2 %), leukocytosis and neutrophilia (7.1 %) and increased LDH (6.1 %). LeukoCIM was effective in patients receiving chemotherapy, because it accelerated neutrophil recovery, decreased the incidence of febrile neutropenia and improved delivery of protocol doses of chemotherapy on time. Additionally, this product was considered safe for the studied patients since just known adverse events were reported
Original Title
Eficacia y seguridad del ior LeukoCIM (FEC-G) en pacientes con neutropenia posquimioterapia
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Also available on line at the web site http://bvs.sld.cu/revistas/far/vol45_1_11/far03111.htm
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Journal Article
Journal
Revista Cubana de Farmacia (Online); ISSN 1561-2988;
; v. 45(1); [vp]

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AbstractAbstract
[en] Invasive pulmonary aspergillosis may be a major cause of lethal opportunistic infection in neutropenic patients. The purpose of this report is to describe a combined treatment modality involving transthoracic injection of amphotericin B and gelatin solution for persistent mycetoma within the cavity. Mycetoma may interfere with consolidation chemotherapy after intravenous injection of ampho-tericin B for invasive pulmonary aspergillosis in a patient with acute monocytic leukemia in whom neutropenia developed during remission induction chemo-therapy.=20
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8 refs, 1 fig
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Journal Article
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Journal of the Korean Radiological Society; ISSN 0301-2867;
; v. 39(4); p. 705-708

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Churilov, G.I.; Churilov, D.G.; Polishchuk, S.D.; Churilova, V.V., E-mail: genchurilov@yandex.ru, E-mail: churilov.dmitry@yandex.ru, E-mail: svpolishuk@mail.ru
Collection of abstracts of XI Annual Conference of Nanotechnological Society of Russia2020
Collection of abstracts of XI Annual Conference of Nanotechnological Society of Russia2020
AbstractAbstract
No abstract available
Original Title
Otsenka vozmozhnykh otdalennykh toksicheskikh ehffektov nanochastits metallov
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Source
Andreyuk, D.S.; Bykov, V.A. (eds.); Obshcherossijskaya Obshchestvennaya Organizatsiya «Nanotekhnologicheskoe Obshchestvo Rossii», Moscow, Zelenograd (Russian Federation); Fond Infrastrukturnykh i Obrazovatel'nykh Programm, Gruppa ROSNANO, Moscow (Russian Federation); 166 p; ISBN 978-5-9500377-6-4;
; 2020; p. 145-147; 11. Annual Conference of Nanotechnological Society of Russia; XI ezhegodnaya konferentsiya Nanotekhnologicheskogo obshchestva Rossii; Moscow (Russian Federation); 17-20 Dec 2020; 6 refs.

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