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[en] A search of the Cambridge Structural Database (CSD, version 5.05, 1993) was performed in order to compare the geometrical features of the hydrogen bonds involving on the one hand amino groups and on the other hand carboxylates, sulfonates or monohydrogen phosponates. Phosphonates were not considered because only four entries containing amino and phosphonate moieities were located in the CSD. The hydroxylic group of monohydrogen phosphonates primarily acts as a hydrogen-bond donor. The three moieties under study show NH..O hydrogen bonds with similar geometrical features. This statistical analysis has focused on the hydrogen-bond distances and angles and on the distributions of the H atoms around the acceptor O atoms of carboxylates, sulfonates or monohydrogen phosphonates. (orig.)
Journal
Acta Crystallographica. Section B: Structural Science; ISSN 0108-7681; 
; CODEN ASBSDK; v. 51(1); p. 103-107
; CODEN ASBSDK; v. 51(1); p. 103-107
[en] We have designed and synthesized functionalized dihydrofurylphosphonates that are constrained analogs of 1-alkenyl-phosphonate derivatives of purine/pyrimidine nucleotides as they bear phosphonyl groups at the 3-position and bases at the methyl group of the 5-position of the furan ring. This newly designed dihydrofurylphosphonate analogs of nucleotide showed antiviral activity. Through the current synthetic strategy, structural diversification can be easily attainable for structure activity relationship study and for the better antiviral compounds. Phosphonate esters play an important role in studying the biological system as a hydrolytically stable replacement of phosphate groups and as prodrugs of phosphonates. In continuation of our study on the chemistry of 1-alkenylphosphonates, we were interested in designing and developing versatile synthetic routes to conformationally constrained structures of al-kenylphosphonate nucleotide analogs
Journal
Bulletin of the Korean Chemical Society; ISSN 0253-2964; ; v. 31(8); p. 2139-2140
; v. 31(8); p. 2139-2140
[en] A simple efficient and neat synthesis of α-hydroxy phosphonates has been accomplished from aromatic/ heterocyclic aldehydes and diethyl phosphite using KHSO4 as a catalyst under solvent-free conditions at ambient temperature. These compounds are characterized by spectral and analytical data and tested for their anti-oxidant activity
Journal
Bulletin of the Korean Chemical Society; ISSN 0253-2964; ; v. 32(9); p. 3343-3347
; v. 32(9); p. 3343-3347
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