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AbstractAbstract
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Original Title
Caracteristiques des proteines plasmatiques et des recepteurs utilises pour le dosage des steroides. Dosage de la progesterone plasmatique a l'aide de la progesterone binding plasma protein (PBP)
Primary Subject
Source
Institut National de la Sante et de la Recherche Medicale (INSERM), 75 - Paris (France); p. 131-147; 1972; Institut National de la Sante et de la Recherche Medicale; Boulogne, France; Seminar on radioimmunoassay; Paris, France; 15 May 1972
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AbstractAbstract
[en] A simple procedure for the preparation of 21-3H- pregnenolone using pregnenolone as starting material is described. The procedure involved removal of the C-21-methyl group of the steroid and the side-chain was constructed with 3H-CH3MgI in two steps: a Grignard reaction followed by oxidation of the resulting alcohol. An overall yield of 71% was achieved. (author)
Record Type
Journal Article
Journal
Journal of Labelled Compounds and Radiopharmaceuticals; ISSN 0362-4803;
; v. 22(4); p. 353-358

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AbstractAbstract
No abstract available
Original Title
Nouvelle methode de transformation de la progesterone 14C-4 en pregnenolone 14C-4 par l'intermediaire du trimethylsilyloxy-3β ethylenedioxy-20.20 pregnadiene-3.5 14C-4
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Journal Article
Journal
C. R., Ser. C; v. 276(8); p. 715-717
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AbstractAbstract
[en] 26,26,26,27,27,27 Hexadeuterio cholesterol has been prepared in 9 steps from pregnenolone and hexadeuterio acetone with an overall yield of 7%. (author)
Record Type
Journal Article
Journal
Journal of Labelled Compounds and Radiopharmaceuticals; ISSN 0362-4803;
; CODEN JLCRD4; v. 38(9); p. 803-808

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AbstractAbstract
No abstract available
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21. National Congress of the Italian Society for Nuclear Medicine and Biology; Santa Margherita Ligure (Italy); 29 May - 1 Jun 1985; Published in summary form only.
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Journal Article
Literature Type
Conference
Journal
Journal of Nuclear Medicine and Allied Sciences; CODEN JNMSD; v. 29(1-2); p. 89
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AbstractAbstract
No abstract available
Original Title
Synthesen radioaktiv markierter Verbindungen. 44
Source
Short note.
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Journal Article
Journal
Zeitschrift fuer Chemie; ISSN 0044-2402;
; v. 19(6); p. 216

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AbstractAbstract
[en] From clinical experience it is known that medroxyprogesterone acetate (MPA) can increase the radiosensitivity of adenocarcinomas of the corpus uteri. This study investigates this phenomenon in vitro. Primary explants of highly differentiated adenocarcinomas were irradiated with or without pretreatment with MPA and compared with an untreated control group and to a group treated with MPA only. Cell culture itself was performed on an agarose medium in order to prevent overgrowth by fibroblasts. Untreated samples formed 43 +/- 5 clones, explants treated with MPA only produced 39 +/- 5 clones, a difference which was not statistically different; samples irradiated without pretreatment produced 16 +/- 8 and samples after combined treatment 9 +/- 3 clones (all values means +/- SD). This numeric reduction of cell growth through preirradiation treatment with MPA was statistically significant. The effect of MPA as a radiosensitizer may be due to its potential to prolong the radiosensitive G2 phase of the cell cycle. This effect of MPA may be useful also in other hormone-dependent tumors
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Journal Article
Journal
Cancer (Philadelphia); ISSN 0008-543X;
; v. 54(6); p. 999-1001

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AbstractAbstract
[en] The alpaca and llama are considered to be seasonally reproductive (from December to March) and given good feeding conditions are reproductively active throughout the year. The males reach puberty at the age of about 2 years when they are free from peno-preputial adhesions. Puberty in the females is affected by body weight and may be reached at the age of 12 months. The females do not have sexual cycles but follicular waves, therefore oestrus varies from 2 to 36 days. Copulation takes place in a seated position and lasts from 5 to 50 minutes; ovulation is induced by coitus, hCG, GnRH and the semen of the alpaca and the bull. 'Spontaneous' ovulation has been observed at the height of the reproductive season and is caused by mechanisms which are not well defined. Multiple ovulation occurs in 10% of females but the number of multiple births is very low. The corpus luteum (CL) forms after mating, attaining maximum size and having the greatest secretory activity on day 9(14.0 nmol/L); it lasts for the 11 months of gestation. If there is no pregnancy, shrinkage of the corpus luteum begins between days 10 and 13 and the progesterone levels fall rapidly. The incidence of embryonic mortality during the first two months of gestation is high. Gestation lasts approximately 342 days, and 93.5% of births occur during the daytime when the environmental conditions are favourable for the newborn animal. The placenta is diffuse and epitheliochorial. Uterine involution is completed within 20 days after birth. Intra- and inter-specific artificial insemination tests have been carried out with intra-uterinal implantation of semen. Embryonic transplant tests have also been conducted. (author)
Original Title
Fisiologia de reproduccion de la alpaca
Primary Subject
Source
International Atomic Energy Agency, Vienna (Austria); Food and Agriculture Organization of the United Nations, Rome (Italy); Proceedings series; 696 p; ISBN 92-0-010286-7;
; 1986; p. 149-177; IAEA; Vienna (Austria); International symposium on the use of nuclear techniques in studies of animal production and health in different environments; Vienna (Austria); 17-21 Mar 1986; IAEA-SM--292/16; CONTRACT IAEA-R-3411/RB; 31 refs, 8 figs, 11 tabs.

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Book
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Conference
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Edqvist, L.E.; Frederiksson, G.; Kindahl, H.; Larsson, K.; Madej, A.
The use of nuclear techniques to improve domestic buffalo production in Asia1984
The use of nuclear techniques to improve domestic buffalo production in Asia1984
AbstractAbstract
[en] Oestrous cycles of shorter duration (8-12 days) are usually found when either dairy or beef cows resume cyclicity post partum. The incidence of short cycle is so high that it should be considered a normal physiological phenomenon. Strong evidence in beef cattle suggests that the short cycle follows an ovulation (probably the same in dairy cows). In dairy cows it is likely that a premature release of prostaglandin is responsible for the short luteal phase (probably the same in beef cows). The occurrence of short oestrous cycles is incompatible with the establishment of pregnancy. In water buffaloes the occurrence of short oestrous cycles following weaning has to be considered and breeding of animals subsequenty adjusted. (author)
Primary Subject
Source
Joint FAO/IAEA Div. of Isotope and Radiation Applications of Atomic Energy for Food and Agricultural Development, Vienna (Austria); Panel proceedings series; 218 p; ISBN 92-0-111484-2;
; 1984; p. 79-83; IAEA; Vienna (Austria); Research co-ordination meeting on use of nuclear techniques to improve domestic buffalo production in Asia; Manila (Philippines); 30 Jan - 3 Feb 1984

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Book
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Conference
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AbstractAbstract
[en] [4-14C]-Progesterone is converted into [4-14C]-20, 20-ethylene-dioxypregn-4-ene-3-one through the eniminium perchlorate intermediate. Silylation of the ethylenedioxy derivative gives rise to [4-14C]-3β-trimethylsilyloxy-20, 20-ethylenedioxypregna-3,5-diene which is reduced stereospecifically into [4-14C]-3β-hydroxy-20, 20-ethylenedioxy-5-pregnene. Cleavage of the protecting group leads to [4-14C]-pregnenolone with a radiochemical yield of 50% based on [4-14C]-progesterone after purification; specific activity: 59mCi/mM
[fr]
La progesterone 14C-4 est transformee en ethylenedioxy-20, 20 pregnene-4 one-3 14C-4 par l'intermediaire du perchlorate d'eniminium. La silylation du derive ethylenedioxy fournit quantitativement le trimethyl-silyloxy-3β ethylenedioxy-20, 20 pregnadiene-3,5 14C-4 qui est reduit stereospecifiquement en hydroxy-3β ethylenedioxy-20, 20 pregnene-5 14C-4. Le clivage du groupe protecteur conduit a la pregnenolone 14C-4 avec un rendement radiochimique de 50% par rapport a la progesterone 14C-4, apres purification; activite specifique-59mCi/mMOriginal Title
Nouvelle methode de transformation de la progesterone 14C-4 en pregnenolone 14C-4 par l'intermediaire du trimethylsilyloxy-3β ethylenedioxy-20,20 pregnadiene-3,5 14C-4(1)
Record Type
Journal Article
Journal
Bulletin de la Societe Chimique de France, Part 2; (no. 1); p. 233-236
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