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AbstractAbstract
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Journal Article
Literature Type
Progress Report
Journal
Soil Science and Plant Nutrition (Tokyo); v. 16(4); p. 150-153
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AbstractAbstract
[en] A method is described for the synthesis of the racemic [methyl-d3] forms of the nicotine metabolites cis-3'-hydroxycotinine and trans-3'-hydroxycotinine. The key intermediate was [methyl-d3]-N-methylhydroxylamine, obtained from a selective hydrogenation of d3-nitro-methane. This intermediate was converted to [methyl-d3]-α-3-pyridyl-N-methylnitrone, which was condensed with methyl acrylate to give a mixture of isomeric isoxazolidines. The hydrogenolysis of this mixture afforded a 70:30 mixture of [methyl-d3] cis- and trans-3'-hydroxycotinine, from which the pure cis-isomer could be isolated by recrystallization from acetone. [Methyl-d3]-trans-3'-hydroxycotinine could be prepared in high yield from the cis-isomer via chiral inversion utilizing a Mitsunobu reaction, or by chromatographic separation from a mixture of the cis- and trans-3'-benzoyloxycotinine, followed by O-debenzoylation in methanolic NaOH. (author)
Record Type
Journal Article
Journal
Journal of Labelled Compounds and Radiopharmaceuticals; ISSN 0362-4803;
; CODEN JLCRD4; v. 34(11); p. 1001-1009

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AbstractAbstract
No abstract available
Record Type
Journal Article
Journal
Journal of Labelled Compounds; v. 9(2); p. 253-259
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AbstractAbstract
[en] This account describes how antibodies specific for nicotine and its metabolites and for various prostaglandins and their metabolites have been used to develop sensitive RIA's for these compounds. Thus far, antibodies have been prepared and RIA's developed for at least 100 other compounds of pharmacological importance. It has been calculated that an individual animal has the potential to produce antibodies that can recognize 107 and perhaps up to 108 diverse immunodominant moieties. Nature, therefore, has provided the pharmacologist and synthetic chemist with an analytical system of extraordinary specificity that can be adapted to the quantitative determination of a wide variety of pharmacologically active molecules. It is clear that RIA will be an important analytical tool in research as well as in the clinical laboratory
Primary Subject
Record Type
Journal Article
Journal
Accounts of Chemical Research; v. 8(10); p. 342-347
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Mahoney, N; Rastogi, V; Cahill, S; Girvin, M; Almo, S
Brookhaven National Lab., Upton, NY (United States); National Synchrotron Light Source (United States). Funding organisation: USDOE Office of Energy Research (ER) (United States)2000
Brookhaven National Lab., Upton, NY (United States); National Synchrotron Light Source (United States). Funding organisation: USDOE Office of Energy Research (ER) (United States)2000
AbstractAbstract
No abstract available
Primary Subject
Source
AC02-98CH10886; Available from Brookhaven National Lab., Upton, NY (US)
Record Type
Journal Article
Journal
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AbstractAbstract
No abstract available
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Record Type
Journal Article
Journal
Arch. Int. Pharmacodyn; v. 195 p. 99-108
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AbstractAbstract
No abstract available
Original Title
Kompleksoobrazovanie toriya s nekotorymi aminokislotami
Source
for English translation see the journal Sov. Radiochem.; published in summary form only.
Record Type
Journal Article
Journal
Radiokhimiya; (no.6); p. 901-902
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AbstractAbstract
[en] Short communication
Original Title
II. Karlshorster Kolloquium ''Klinische Aspekte der Umweltmedizin'', Berlin, 07. Mai 1993
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Secondary Subject
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Journal Article
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AbstractAbstract
[en] Medicago sativa cv. Pianguan, an excellent local germplasm in Shanxi province, China, with the resistance to cold and drought is broadly planted. Many studies have showed that drought resistance of plants is positively correlated with the accumulation of proline, P5CS and delta-OAT play important roles in synthesis of proline. In this study, the proline content, activities and expression of P5CS and delta-OATmRNA were detected in Medicago sativa cv. Pianguan under drought stress. The results showed that the proline content in Medicago sativa cv. Pianguan increased in the process of drought stress. The expression levels of P5CSb and delta-OATmRNA changed correspondingly at the different stress time point. In conclusion, P5CS and delta-OAT could participate in the drought resistance process by regulating proline content in Medicago sativa cv. Pianguan. (author)
Primary Subject
Record Type
Journal Article
Journal
Pakistan Journal of Botany; ISSN 0556-3321;
; v. 48(1); p. 137-142

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Uslu, I.; Tanker, E.; Aksu, M. L.
Turkish Atomic Energy Authority, Ankara (Turkey)1998
Turkish Atomic Energy Authority, Ankara (Turkey)1998
AbstractAbstract
[en] Cigaratte is known to be hazardous to health due to nicotine and tar it contains.This is indicated on cigaratte packets by health warnings.However there is less known hazard of smoking due to intake of radioactive compounds by inhalation. This study dwells upon the radioactive hazard of smoking
Primary Subject
Source
Available from ILO Turkey
Record Type
Journal Article
Journal
Turkish Journal of Nuclear Sciences; ISSN 0254-5446;
; v. 25(2); p. 61-70

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Reference NumberReference Number
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