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[en] The 2003 RIA R and D Workshop was held on August 26-28, 2003 at the Four Points Sheraton Hotel in Bethesda, Maryland. This Workshop was chaired by Satoshi Ozaki of BNL and sponsored by the Nuclear Physics Division of DOE, with the help of Oak Ridge Institute for Science and Education (ORISE). The purpose of this workshop was to understand the present status of R and D efforts for RIA, to evaluate the needs for further R and D, and to identify opportunities for international collaborations. The workshop examined and documented the current pre-conceptual design for RIA, identifying areas where decisions on technical options remain. The status of the current RIA R and D program was documented, recognizing areas where efforts were needed in light of what had been learned. The ongoing and planned R and D activities for operating and planned rare-isotope facilities were presented, enabling the workshop to be a venue to develop coordinated R and D efforts of mutual benefit to U.S. and international efforts. The scientific program for the first day (August 26, 2003) consisted mostly of invited talks presented by major research groups involved in RIA and other RI beam facilities. The talks included those covering: Science of RIA and the RIA Facility Performance Requirements; The Reference RIA Facility Pre-CDR design that was used for the NSAC cost exercise (M. Harrison Sub-Panel) in January 2001; New or latest perspectives on the RIA design at ANL and MSU; and RI Beam facility plans and overview of the R and D activities at overseas laboratories. The second day (August 27, 2003) was devoted to contributed talks on continuing R and D, including that which had been supported by DOE RIA R and D funds. The third day (August 28, 2003) began with open panel discussions in the morning, including further input from participants. The panel members discussed the present status of the RIA planning and R and D needs in a closed session for the rest of the day, and then worked on report planning and writing. This Workshop enjoyed participation by over 100 scientists, including those who represented international rare ion beam facilities. The workshop also had the good fortune of having an outstanding panel of experts covering subsystems of RIA in depth
[en] Review of status and prospects for development of the methods of radioimmunoassay (RIA) is presented. Considerable role of the RIA methods in the progress of medicine and biology as well as in the diagnosis of various diseases is accentuated. Prospects in radioimmunology are related to the establishment of RIA labs (groups) in research institutes of endocrinology, oncology, cardiology, neurosurgery, gastroenterology as well as to the establishing regional RIA centers equipped with modern instrumentation. Attention is paid to the personnel training
[ru]Представлен обзор состояния и перспектив развития методов радиоиммунологического анализа (РИА). Отмечена важность методов РИА, а также значительность успехов в диагностике различных заболеваний. Перспективы развития радиоиммунологии связываются с организацией лабораторий (групп) РИА в научно-исследовательских институтах эндокринологического, онкологического, кардиологического, нейрохирургического и гастроэнтерологического профиля, а также с созданием региональных центров РИА, оснащенных современным оборудованием. Уделяется внимание подготовке кадров
[en] Among the pituitary hormones, a FSH radioimmunoassay procedure has been established. The labelling and the separation methods are suitable for a FSH radioimmunoassay. However, the gel filtration technique is superior to the starch gel electrophoresis in view of the simplicity, short separation time and the bindability of the purified labelled antigen to its antibody. For the separation of the free antigen from the antibody bound, the double antibody technique could be successfully applied.
[en] Software engineering process Windows-based RIA IP10 with Visual C≠ programming language have done. Engineering process consists of software upgrades at RIA in 2012 so that they can be used also as a counter device for early examination digestive tract. The kit used was CEA IRMA Kit with 7 number of standard tube. Required the addition of the choice of the analysis process, the choice of ″digestive″ standard, calculation function modules, creates the standard curve, and calculation of the concentration of the sample, followed by reporting the results of diagnosis. (author)
[en] Due to the financial limitations of hospitals in Cuba since the 1990s, and using CENTIS's coverage of a licensed laboratory for working with radioactive substances, an experienced staff made it possible a centralized analytical service (SDA) was considered by the RIA / IRMA method, which would help to alleviate the unmet demand for analysis, and in accordance with the requirements established by the Good Clinical Laboratory Practices (BPLC 03- 2009). An SDA Quality System was designed as a complement to the CENTIS Quality System, which would guarantee the reliability of the results. In order to ensure the traceability of the samples and their results through all stages of service execution, a computer system was designed as a reliable tool, in addition to the use of certified reference materials, reagent sets, periodic and constant calibration of the samples. Means of measurement (pipettes, metering equipment), training and evaluation of personnel in RIA // IRMA test techniques applied. The new potentialities of SDA are directed towards the introduction of tumor markers. Tumor markers are currently used primarily to evaluate the cancer reaction to treatment and to control relapse, although its role in the early detection and diagnosis of cancer is still being studied.
[en] Scintillation proximity assay (SPA) is a unique type of radioimmunoassay and makes it possible to use radioisotopes for monitoring binding reactions continuously without separation procedure. Microbeads containing a fluorophor are covalently linked to antibody or receptor. When a radiolabeled antigen or ligand is added it binds to the beads and the emitted short range electrons, excite the fluorophor in the beads. The light emitted can be measured in a scintillation counter. 3H or 125I has been used for SPA. The sensitivities achieved with SPA are comparable to the sensitivities of other procedures. SPA is applicable to immunology, receptor binding, monitoring interactions of biomolecules and study for the kinetics of interaction between receptors and ligands
[en] This paper describes the conception of RIA and database management, analyzes the testing system of RIA using modular design techniques and related programs in light of actual needs. Achieves the database management functions of the RIA testing system through examples. (authors)
[en] The method of making a single background quality control charge and its application in the long-term stability of RIA counter are studied. The results show that the method can be regarded as an index of the long-term stability checking and quantification
[en] The objectives of AIDA (Artificial Insemination Database Application) and its companion GAIDA (Guide to AI Data Analysis) are to address two major problems in on-farm research on livestock production. The first is the quality of the data collected and the second is the intellectual rigor of the analyses and their associated results when statistically testing causal hypotheses. The solution is to develop a data management system such as AIDA and an analysis system such as GAIDA to estimate parameters that explain biological mechanisms for on-farm application. The system uses epidemiological study designs in the uncontrolled research environment of the farm, uses a database manager (Microsoft Access) to handle data management issues encountered in preparing data for analysis, and then uses a statistical program (SYSTAT) to do preliminary analyses. These analyses enable the researcher to have better understanding of the biological mechanisms involved in the data contained within the AIDA database. Using GAIDA as a guide, this preliminary analysis helps to determine the strategy for further in-depth analyses. (author)