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Kim, Jin Kyu; Kim, J. H.; Yang, J. S.
Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)2008
Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)2008
AbstractAbstract
[en] It is expected that motivation and basic technologies for the future R and D plans can be provided from the results of this study. This study has been done to develop fundamentals for radiation applications based on the existing radiation technology, and to establish technical basis for enhancing efficacy of radiation utilization by studying the simultaneous application of ionizing radiation with another factor. Application of radiation technology together with the existing technologies to enhance the physical, chemical, biological characteristics through structural changes of biomolecules will exert a favorable influence on the creation of de novo scientific and industrial values. A theoretical model for the combined action of ionizing radiation with another factor can make it possible to predict a prior the maximum value of synergistic interaction and the conditions for it. Furthermore, the results of this study give a clues for establishment of fundamental theories associated with positive efficacy of radiation applications
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Dec 2008; 205 p; Also available from KAERI; 270 refs, 45 figs, 11 tabs
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Rocha, B.A.M.; Bezerra, M.J.B.; Bezerra, G.A.; Alencar, K.L.L.; Nascimento, K.S.; Naganao, C.S.; Sampaio, A.H.; Cavada, B.S.; Delatorre, P.; Rodrigues, N.V.; Pires, A.F.; Assreuy, A.M.S.; Marins, J.L.
Laboratorio Nacional de Luz Sincrotron (LNLS), Campinas, SP (Brazil)2012
Laboratorio Nacional de Luz Sincrotron (LNLS), Campinas, SP (Brazil)2012
AbstractAbstract
[en] Full text: Lectins are a structural heterogeneous group of proteins possessing at least one non-catalytic domain that binds reversibly to a specific mono or oligosaccharide. Diocleinae lectins exhibit glucose/mannose monosaccharide binding specificity and studies of their chemical and physicochemical properties revealed a high degree of identity in their amino acid sequences and three dimensional structures. This study investigated structural/functional relationships between lectins obtained from Dioclea violacea (DVL) and Dioclea rostrata (DRL). The purified lectin (DVL) was solubilized in 20 mM Tris-HCl pH 7.6 with 5 mM CaCl2 and MnCl2 buffer and incubated during one hour before the crystallization experiments with the ligand X-Man (5-bromo-4-chloro-3-indolyl-α-D-mannose) at 3 mM. Crystals of DVL grew in condition 33 of Crystal Screen I (4M Sodium formate) and belong to the orthorhombic space group I222. The structure of DVL at 2.6 resolution was obtained by molecular replacement using the coordinates of DRL (PDB code 2ZBJ), after the last refinement the structure presented R factor of 0.23 and R free of 0.27. The crystal structures reveal differences between them and could be related to relaxant activity. The conformation of residues HIS51, HIS131 and GLU205 and others positioned at CRD lead to different lectin binding activities. In fact, the pocket in DVL is small and deep and promotes weak interaction with carbohydrates, while DRL pocket is large and shallow, allowing strong interaction between CRD and sugars. This can explain why DVL and DRL elicited different degrees of aorta relaxation showing maximal effects of 43 % and 96 %, respectively. (author)
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2012; [1 p.]; 22. RAU: Annual meeting of the LNLS/CNPEM users; 22. RAU: Reuniao anual de usuarios do LNLS/CNPEM; Campinas, SP (Brazil); 28-29 Feb 2012; Available in abstract form only; full text entered in this record
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Miscellaneous
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Li, Jingguo; Yu, Zhiqiang; Jiang, Hao; Zou, Gang; Zhang, Qijin, E-mail: gangzou@ustc.edu.cn2012
AbstractAbstract
[en] Herein, a novel smart nanocontainer was developed by incorporating photo-responsive azobenzene derivative/cyclodextrin (Azo–CD) supramolecular complex into pH-responsive polydiacetylene (PDA) vesicles matrix. The designed nanocontainer exhibited excellent cell-toxicity, and the controlled release property response to external photo and pH stimuli. The photo-controlled inclusion and exclusion reaction between α-cyclodextrin (α-CD) and azobenzene moiety were used to act as the driving force to induce photo-triggered controlled release behavior of the designed nanocontainer. Moreover, the pH-responsive PDA vesicle matrix endowed the designed system with a controlled release property upon pH variation. The facile preparation procedures and their efficiency of response to the external stimuli render the novel smart nanocontainer potential candidate for future applications in remote controlled drug release. -- Graphical abstract: Herein, we developed a novel smart nanocontainer comprising the azobenzene derivative/cyclodextrin supramolecular complex and polydiacetylene vesicles, which exhibited excellent biocompatibility, and controlled release property response to external photo and pH stimuli. Highlights: ► We developed a novel dual-responsive smart polydiacetylene nanocontainer. ► The azobenzene/cyclodextrin complex was introduced into polydiacetylene vesicles. ► The designed nanocontainer exhibited excellent biocompatibility and stability. ► 365 and 435 nm light irradiations are used to realize photo controlled release. ► The smart nanocontainer exhibited controlled release property upon pH variation.
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S0254-0584(12)00614-1; Available from http://dx.doi.org/10.1016/j.matchemphys.2012.06.056; Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Feinberg, H.
Stanford Linear Accelerator Center, Menlo Park, CA (United States); Stanford Synchrotron Radiation Lab. (United States). Funding organisation: USDOE Office of Science (United States)2001
Stanford Linear Accelerator Center, Menlo Park, CA (United States); Stanford Synchrotron Radiation Lab. (United States). Funding organisation: USDOE Office of Science (United States)2001
AbstractAbstract
No abstract available
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Source
SLAC-REPRINT--2001-125; AC03-76SF00515
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Journal Article
Journal
Science (Washington, D.C., 1979-); ISSN 0193-4511;
; (1Jan2001issue); [v p.]

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Povolo, F.
International Centre for Theoretical Physics, Trieste (Italy)1990
International Centre for Theoretical Physics, Trieste (Italy)1990
AbstractAbstract
[en] A procedure to obtain the parameters of the constitutive equations used to describe the shear-thinning behaviour of polysaccharides is presented. It is shown that the existence or not of a master log viscosity-log shear rate curve, for all concentrations, is independent from the constitutive equation used to describe the data. Once the master curve is constructed it can be used to obtain the parameter of the constitutive equation with a higher accuracy, since the experimental range is extended. Some application to experimental data on polysaccharides, reported in the literature, are presented. A fitting procedure to usual constitutive equations is given based on the master curve and on its first derivative. Finally, the applicability of a method proposed recently in the literature, to obtain the parameters of a constitutive equation for polysaccharides, is discussed in detail. (author). 10 refs, 10 figs, 2 tabs
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Jul 1990; 24 p
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Report
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AbstractAbstract
[en] Sets of sialic acid-containing trisaccharides having different internal and terminal linkages have been synthesized to develop a sensitive method for analysis of the reducing terminal linkage positions. The trisaccharides, sialyl(α 2-3)Gal(β 1-3)GalNAc and sialyl(α 2-3)Gal(β 1-X)GlcNAc where X=3, 4 and 6, were synthesized and examined using electrospray ionization (ESI)-collision induced dissociation (CID) tandem mass spectrometry (MS/MS). The compounds chosen for this study are related to terminal groups likely to be found on polylactosamine-like glycoproteins and glycolipids which occur on the surface of mammalian cells. The purpose of this study is to develop tandem mass spectrometral methods to determine detailed carbohydrate structures on permethylated or partially methylated oligosaccharides for future applications on biologically active glycoconjugates and to exploit a faster method of synthesizing a series of structural isomeric oligosaccharides to be used for further mass spectrometry and instrumental analysis
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19 refs, 5 figs
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Journal Article
Journal
Bulletin of the Korean Chemical Society; ISSN 0253-2964;
; v. 26(9); p. 1347-1353

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Kovacik, V.; Petrakova, E.; Hirsch, J.; Mihalov, V.; Heerma, W.; Versluis, C.
8th Czechoslovak spectroscopic conference. Abstracts1988
8th Czechoslovak spectroscopic conference. Abstracts1988
AbstractAbstract
[en] Published in summary form only
Source
Ceskoslovenska Spektroskopicka Spolecnost, Prague; 162 p; 2 Jun 1988; p. 102; 8. Czechoslovak spectroscopic conference; Ceske Budejovice (Czechoslovakia); 19-24 Jun 1988
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Miscellaneous
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Conference
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AbstractAbstract
[en] Nano-structured materials with a controlled microstructure and tailored properties at a scale below 100 nm are of interest for applications in micro-mechanical, sensor and biomedical devices. In contrast to top-down manufacturing processes the formation of solid matter structures in nature is templated and directed by biomacromolecules such as polysaccharides and polypeptides. A promising biomimetic route for the directed deposition of ceramic materials is the application of anisotropically structured biomacromolecules as patterned templates. The polysaccharides exhibit a hierarchical multi scale order as well as self-assembly properties. The bio-inspired deposition and formation of ceramic phases on biomolecular polysaccharide templates was investigated. The polysaccharides were used at various structural levels from the molecular scale up to three-dimensional parts in the millimetre range. The versatility of polysaccharide shaping capabilities was explored using dissolved polysaccharide molecules as well as thin films for the or simultaneous or successive formation of inorganic mineral phases. Microalgae with a spherical appearance of 5 micro-m were applied in mineralisation studies. The extracellular polysaccharide (EPS) layers on the microalgae were used as biotemplates for manufacturing of functional ceramics. The obtained results on the mineralisation of inorganic phases on polysaccharides are adapted for novel biomimetic routes used in the fabrication for functional and biomedical ceramics. (author)
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Farooque, M.; Rizvi, S.A.; Ahmed, K. (eds.); Secretariat International Symposium on Advance Materials, Rawalpindi (Pakistan); 594 p; 2007; p. 13-19; 10. International Symposium on Advanced Materials; Rawalpindi (Pakistan); 3-7 Sep 2007
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Book
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Conference
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Sackschewsky, M.R.
Westinghouse Hanford Co., Richland, WA (United States). Funding organisation: USDOE, Washington, DC (United States)1993
Westinghouse Hanford Co., Richland, WA (United States). Funding organisation: USDOE, Washington, DC (United States)1993
AbstractAbstract
[en] Natural polysaccharides were evaluated as alternatives to commercially available dust-control agents for application in buried-waste and contaminated-soil remediation situations. Materials were identified and evaluated with specific criteria in mind: the materials must be environmentally benign and must not introduce any additional hazardous materials; they must be effective for at least 2 or 3 days, but they do not necessarily have to be effective for more than 2 to 3 weeks; they should be relatively resistant to light traffic; they must not interfere with subsequent soil treatment techniques, especially soil washing; and they must be relatively inexpensive. Two products, a pregelled potato starch and a mixture of carbohydrates derived from sugar beets, were selected for evaluation. Testing included small- and large-scale field demonstrations, laboratory physical property analyses, and wind-tunnel evaluations
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Sep 1993; 107 p; CONTRACT AC06-87RL10930; Also available from OSTI as DE94001225; NTIS; US Govt. Printing Office Dep
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Berti, Fernanda V.; Rambo, Carlos R.; Dias, Paulo F.; Porto, Luismar M., E-mail: fernanda@intelab.ufsc.br2013
AbstractAbstract
[en] When cultured under static conditions, bacterial cellulose pellicles, by the nature of the polymer synthesis that involves molecular oxygen, are characterized by two distinct surface sides. The upper surface is denser in fibers (entangled) than the lower surface that shows greater surface porosity. Human umbilical vein endothelial cells (HUVECs) were used to exploit how the microarchitecture (i.e., surface porosity, fiber network structure, surface topology, and fiber density) of bacterial cellulose pellicle surfaces influence cell–biomaterial interaction and therefore cell behavior. Adhesion, cell ingrowth, proliferation, viability and cell death mechanisms were evaluated on the two pellicle surface sides. Cell behavior, including secondary necrosis, is influenced only by the microarchitecture of the surface, since the biomaterial is extremely pure (constituted of cellulose and water only). Cell–cellulose fiber interaction is the determinant signal in the cell–biomaterial responses, isolated from other frequently present interferences such as protein and other chemical traces usually present in cell culture matrices. Our results suggest that microarchitecture of hydrogel materials might determine the performance of biomedical products, such as bacterial cellulose tissue engineering constructs (BCTECs). - Highlights: • Topography of BC pellicle is relevant to determine endothelial cells' fate. • Cell–biomaterial response is affected by the topography of BC-pellicle surface. • Endothelial cells exhibit different behavior depending on the BC topography. • Apoptosis and necrosis of endothelial cells were affected by the BC topography
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S0928-4931(13)00432-3; Available from http://dx.doi.org/10.1016/j.msec.2013.07.029; Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems; ISSN 0928-4931;
; v. 33(8); p. 4684-4691

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