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Diller, T.C.
Stanford Linear Accelerator Center, Menlo Park, CA (United States); Stanford Synchrotron Radiation Lab. (United States). Funding organisation: USDOE Office of Science (United States)2001
Stanford Linear Accelerator Center, Menlo Park, CA (United States); Stanford Synchrotron Radiation Lab. (United States). Funding organisation: USDOE Office of Science (United States)2001
AbstractAbstract
No abstract available
Primary Subject
Source
SLAC-REPRINT--2001-113; AC03-76SF00515
Record Type
Journal Article
Journal
Structure (London); ISSN 0969-2126;
; (1Jan2001issue); [v p.]

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Gray, N.S.; Wodicka, L.; Thunnissen, A.-M.; Norman, T.C.; Kwon, S.; Espinoza, F.H.; Morgan, D.O.; Barnes, G.; LeClerc, S.; Meijer, L.; Kim, S.-H.; Lockhart, D.J.; Schultz, P.G.
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)1998
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)1998
AbstractAbstract
No abstract available
Primary Subject
Source
LBNL/ALS--13049; AC03-76SF00098; Journal Publication Date: July 24 1998
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Journal Article
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Isvoran, Adriana, E-mail: adriana@physics.uvt.ro2004
AbstractAbstract
[en] This paper reveals fractal aspects of the adenylat kinase structure and dynamics. The spatial series of the coordinates of the carbon-alpha atoms of the free enzyme and of its complex with the inhibitor AP5A, respective those of the changes in these coordinates when the enzyme forms the complex with the inhibitor present 1/fβ power spectra with 1<β<2 and it is a signature of fractality. The values of the scaling exponents obtained using the detrended fluctuations analysis method for the same series of data are comprises in the interval 1<α<1.5 and they are in good agreement with those of the spectral coefficient β. The correlation dimensions for the point sets of data are non-integer values and all these results reflect fractality in the analyzed series of data
Primary Subject
Source
S0960077903001000; Copyright (c) 2003 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Chaos, Solitons and Fractals; ISSN 0960-0779;
; v. 19(1); p. 141-145

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Wang, W.; Kim, S.-H.
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, CA (United States). Funding organisation: US Department of Energy (United States)2001
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, CA (United States). Funding organisation: US Department of Energy (United States)2001
AbstractAbstract
No abstract available
Primary Subject
Source
1 May 2001; [vp.]; 12. Annual Meeting on Structural Biology (World Molecular Engineering Network of the..); San Jose del Cabo, Baja Mexico (Mexico); 6-10 May 2001; AC03-76SF00098; Available from www.als.lbl.gov
Record Type
Report
Literature Type
Conference
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Yamaguchi, Hirohito; Hsu, Jennifer L.; Hung, Mien-Chie, E-mail: mhung@mdanderson.org2012
AbstractAbstract
[en] The ubiquitin–proteasome system is essential for multiple physiological processes via selective degradation of target proteins and has been shown to plays a critical role in human cancer. Activation of oncogenic factors and inhibition of tumor suppressors have been shown to be essential for cancer development, and protein ubiquitination has been linked to the regulation of oncogenic factors and tumor suppressors. Three kinases, AKT, extracellular signal-regulated kinase, and IκB kinase, we refer to as oncokinases, are activated in multiple human cancers. We and others have identified several key downstream targets that are commonly regulated by these oncokinases, some of which are regulated directly or indirectly via ubiquitin-mediated proteasome degradation, including FOXO3, β-catenin, myeloid cell leukemia-1, and Snail. In this review, we summarize these findings from our and other groups and discuss potential future studies and applications in the clinic.
Primary Subject
Source
Available from http://dx.doi.org/10.3389/fonc.2012.00015; Copyright (c) 2012 Yamaguchi, Hsu and Hung.; This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Frontiers in Oncology; ISSN 2234-943X;
; v. 2; [9 p.]

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AbstractAbstract
[en] Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator
Primary Subject
Source
S0006-291X(07)00770-X; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 358(1); p. 66-72

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Meijer, L.; Thunnissen, A.; White, A.; Garnier, M.; Nikolic, M.; Tsai, L.-H.; Walter, J.; Cleverley, K.; Salinas, P.; Wu, Y.-Z.; Biernat, J.; Mandelkow, E.-M.; Kim, S.-H.; Pettit, G.
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
Ernest Orlando Lawrence Berkeley National Lab., Advanced Light Source, Berkeley, CA (United States). Funding organisation: US Department of Energy (United States)2000
AbstractAbstract
No abstract available
Primary Subject
Source
LBNL/ALS--13217; AC03-76SF00098; Journal Publication Date: January 2000
Record Type
Journal Article
Journal
Chemistry and Biology (London); ISSN 1074-5521;
; v. 7(1); [10 p.]

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Mesarosova, Monika; Valovicova, Zuzana; Srancikova, Annamaria; Krajcovicova, Zdenka; Milcova, Alena; Sokolova, Romana; Schmuczerova, Jana; Topinka, Jan; Gabelova, Alena, E-mail: alena.gabelova@savba.sk2011
AbstractAbstract
[en] The environmental pollutant 7H-dibenzo[c,g]carbazole (DBC) and its derivative, 5,9-dimethylDBC (DiMeDBC), produced significant and dose-dependent levels of micronuclei followed by a substantial increase in the frequency of apoptotic cells in the V79MZh3A4 cell line stably expressing the human cytochrome P450 (hCYP) 3A4. In contrast, neither micronuclei nor apoptosis were found in cells exposed to the sarcomagenic carcinogen, N-methylDBC (N-MeDBC). A slight but significant level of gene mutations and DNA adducts detected in V79MZh3A4 cells treated with N-MeDBC, only at the highest concentration (30 μM), revealed that this sarcomagenic carcinogen was also metabolized by hCYP3A4. Surprisingly, DBC increased the frequency of 6-thioguanine resistant (6-TGr) mutations only at the highest concentration (30 μM), while DiMeDBC failed to increase the frequency of these mutations. The resistance to 6-thioguanine is caused by the mutations in the hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene. The molecular analysis of the coding region of Hprt gene showed a deletion of the entire exon 8 in DiMeDBC-induced 6-TGr mutants, while no changes in the nucleotide sequences were identified in 6-TGr mutants produced by DBC and N-MeDBC. Based on our results, we suggest that hCYP3A4 is involved in the metabolism of DBC and its tissue-specific derivatives. While hCYP3A4 probably plays an important role in biotransformation of the liver carcinogens, DBC and DiMeDBC, it might only have a marginal function in N-MeDBC metabolism. - Highlights: → DBC activation via CYP3A4 resulted in micronuclei, DNA adduct formation and mutations in V79MZh3A4 cells. → The CYP3A4-mediated DiMeDBC activation caused micronuclei followed by apoptosis in V79MZh3A4 cells. → The genotoxic effects produced by N-MeDBC in V79MZh3A4 cells were negligible. → The hCYP3A4 may play an important role in DBC and DiMeDBC metabolism. → The CYP3A4 might only have a marginal function in N-MeDBC metabolism.
Primary Subject
Source
S0041-008X(11)00264-X; Available from http://dx.doi.org/10.1016/j.taap.2011.06.027; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Viswanathan, G; Sealfon, S C; Hayot, F; Jayaprakash, C, E-mail: fernand.hayot@mssm.edu2008
AbstractAbstract
[en] Kinases serve crucial roles in many cellular signaling pathways that process and transfer information. When signaling kinases phosphorylate two targets, these can serve as branch points that distribute information among two pathways. Responses to stimuli transmitted by activated kinases show high levels of cell-to-cell variation that influence cellular function. We ask how fluctuations around a steady state, due to kinase fluctuations and intrinsic noise, are distributed between two reactions with substrates phosphorylated by a shared kinase. We develop the formalism to answer this question and, for a realistic set of biological constants, we illustrate various features of fluctuations and relaxation times to a steady state. We find that the steady-state response determines the size and range in enzyme concentration of phosphorylated substrate fluctuations, and that the choice of an operating point can have a large impact on how shared kinase noise is distributed among two available pathways
Primary Subject
Secondary Subject
Source
S1478-3975(08)81803-1; Available from http://dx.doi.org/10.1088/1478-3975/5/4/046002; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Physical Biology (Online); ISSN 1478-3975;
; v. 5(4); [10 p.]

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AbstractAbstract
[en] We have demonstrated a new and efficient method for the synthesis of 3-substituted aminoisoxazoles from readily available thiocarbamoyl esters. Mercury (II) chloride appeared to be a Lewis acid of choice among the metals tested in this cyclodesulfurization reaction. Application of this method for the synthesis of substituted aminopyrazoles is now under investigation in our laboratory. 3-Aminoisoxazol-5(4H)-one is an important building block of many biologically active compounds including antimicrobial and antioxidant, K channel opener, and kinase inhibitors. Besides, it could be transformed to fused heterocyclic compounds such as indoles, imidazopyridines, and isoxazolopyrimidines. Condensation reaction of α-cyanoacetate with hydroxylamine was a well known method to access either 3-aminoisoxazol-5(4H)-one or isomeric 5-aminoisoxazol-3(4H)-one depending upon condition. For instance, reaction under the neutral condition provided 3-aminoisoxazolone isomer via acetamidoxime intermediate, whereas 5-aminoisoxazolone isomer was obtained under the alkaline condition
Primary Subject
Source
13 refs, 1 fig, 1 tab
Record Type
Journal Article
Journal
Bulletin of the Korean Chemical Society; ISSN 0253-2964;
; v. 31(11); p. 3071-3072

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