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Trifiletti, Daniel M.; Xu, Zhiyuan; Dutta, Sunil W.; Quiñones-Hinojosa, Alfredo; Peterson, Jennifer; Vance, Mary Lee; Sheehan, Jason P., E-mail: trifiletti.daniel@mayo.edu2018
AbstractAbstract
[en] To compare and describe the time to endocrine remission and new hypopituitarism among patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas after radiosurgery, controlling for several known prognostic factors.
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S0360301618303171; Available from http://dx.doi.org/10.1016/j.ijrobp.2018.02.023; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 101(3); p. 610-617

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AbstractAbstract
[en] Highlights: • Cav-1 knockdown promoted the expression of miR-145, miR-124 and miR-183. • Cav-1 knockdown inhibited the nuclear translocation of EGR1. • Cav-1 knockdown reduced the interaction between EGR1 and KLF5. • Free KLF5 positively regulated the expression of miR-145, miR-124 and miR-183. • miR-145, miR-124 and miR-183 reduced pituitary adenoma cells migration and invasion. Caveolin-1 (Cav-1) is a principal structural protein of caveolae. Cav-1 has been implicated in cancer progression, but its precise functional roles in pituitary adenoma cells remain largely unclear. In this study, we evidenced that the level of cav-1 was elevated in the invasive pituitary adenoma. Cav-1 knockdown restrained the migration and invasion of pituitary adenoma cells. In cav-1-depleting cells, the expression of miR-145, miR-124 and miR-183 were up-regulated. Further investigation showed that cav-1 knockdown inhibited the nuclear translocation of EGR1, reducing the interaction between EGR1 and KLF5. The resulting free KLF5 promoted the expression of miR-145, miR-124 and miR-183 by binding to their promoters, which was blocked by EGR1. Luciferase reporter assay indicated that miR-145 targeted FSCN1, miR-124 targeted PTTG1IP, and miR-183 targeted EZR in pituitary adenoma cells, respectively. Knockdown of FSCN1, PTTG1IP or EZR suppressed the migration and invasion of pituitary adenoma cells. In conclusion, our data suggested that the elevated cav-1 promoted pituitary adenoma cells migration and invasion by regulating the interaction between EGR1 and KLF5.
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S0014482718300089; Available from http://dx.doi.org/10.1016/j.yexcr.2018.01.008; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Graffeo, Christopher S.; Link, Michael J.; Brown, Paul D.; Young, William F.; Pollock, Bruce E., E-mail: pollock.bruce@mayo.edu2018
AbstractAbstract
[en] To analyze factors associated with post–stereotactic radiosurgery (SRS) hypopituitarism among radiation-naïve patients with pituitary adenomas who underwent single-fraction SRS between 2007 and 2014.
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Source
S0360301618304759; Available from http://dx.doi.org/10.1016/j.ijrobp.2018.02.169; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 101(3); p. 618-623

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Abbas, A.; Idriz, S.; Railton, N.J.; McGill, N.; Nasruddin, A.B.; Sandeman, D.D.; Breen, D.J., E-mail: david.breen@uhs.nhs.uk2013
AbstractAbstract
No abstract available
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S0009-9260(12)00518-1; Available from http://dx.doi.org/10.1016/j.crad.2012.06.137; Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
[en] VEGF is one of the key drivers of physiological or pathological angiogenesis hence several VEGF inhibitors are in different stages of clinical development. To further dissect the role of VEGF in different stages of tumor progression in lung tumors, we utilized KrasG12D-LSL GEMMs (genetically engineered mouse models). Intranasal delivery of adenoviruses expressing cre recombinase in KrasG12D-LSL mice results in the expression of mutant Kras that leads to development of tumor lesions ranging from adenomatous hyperplasia to large adenoma and adenocarcinoma over time in lung. In the current study, we treated KrasG12D-LSL mice at 14 weeks post inhalation with three different angiogenic inhibitors including axitinib and PF-00337210 both of which are selective inhibitors of VEGFR and sunitinib which targets VEGFR, C-SF1-R, PDGFR and KIT. Pathology findings showed no significant difference in percentage of adenomatous hyperplastic lesions between the vehicle vs. any of the treatments suggesting that angiogenesis may not play a major role at early stages of tumorigenesis. However, each inhibitor suppressed percentage of benign adenoma lesions and almost fully inhibited growth of adenocarcinoma lesions in the recipients which was consistent with a reduction in tumor vasculature. Treatment with sunitinib which is a multi-targeted RTKI did not provide any advantage compared to selective VEGFR inhibitor further emphasizing role of VEGF in tumor angiogenesis in this model. Overall, our studies indicate significance of VEGF and angiogenesis in a spontaneous model of lung tumorigenesis and provide a proof of mechanism for anti-cancer activity of VEGF inhibitors in this model
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Available from http://dx.doi.org/10.1186/1471-2407-13-213; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648493; PMCID: PMC3648493; PUBLISHER-ID: 1471-2407-13-213; PMID: 23627488; OAI: oai:pubmedcentral.nih.gov:3648493; Copyright (c) 2013 Majeti et al.; licensee BioMed Central Ltd.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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BMC cancer (Online); ISSN 1471-2407;
; v. 13; p. 213

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External URLExternal URL
AbstractAbstract
[en] Brown tumors are an uncommon entity associated with hyperparathyroidism. Initially described with primary hyperparathyroidism, with the widespread use of dialysis, they were also seen to be associated with secondary and tertiary hyperparathyroidism. These are lytic, expansile lesions causing bony pains, and depending on the size and extent, skeletal dysmorphism. The present case illustrates the detection of parathyroid adenoma with multiple brown tumors on 99mTc-sestamibi parathyroid scintigraphy in a patient presenting with facial dysmorphism and multiple bony pains.
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Available from http://dx.doi.org/10.4103/ijnm.IJNM_35_18; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011569; PMCID: PMC6011569; PMID: 29962730; PUBLISHER-ID: IJNM-33-255; OAI: oai:pubmedcentral.nih.gov:6011569; Copyright: (c) 2018 Indian Journal of Nuclear Medicine; This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Indian Journal of Nuclear Medicine; ISSN 0972-3919;
; v. 33(3); p. 255-256

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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CARCINOMAS, COUNTING TECHNIQUES, DIAGNOSTIC TECHNIQUES, DISEASES, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, NEOPLASMS, NUCLEI, ODD-EVEN NUCLEI, RADIOISOTOPE SCANNING, RADIOISOTOPES, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
No abstract available
Original Title
Place de la radiotherapie dans le traitement de l'adenome de l'hypophyse. A propos de deux cas avec revue de la litterature
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13. congress of the French society of oncological radiotherapy; 13. congres national de la Societe francaise de radiotherapie oncologique; Paris (France); 6-8 Nov 2002
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Conference
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AbstractAbstract
[en] Multiple colorectal adenomas (MCRAs) syndrome is a genetic syndrome characterized by multiple colorectal polyps. Patients usually present late in late fourth or fifth decade of life. They have a high risk for developing malignancy. We here present such case of a 61-year-old man with MCRAs who developed malignant degeneration of multiple colorectal polyps, which was demonstrated on 18F-fluorodeoxyglucose positron emission tomography–computed tomography.
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Available from http://dx.doi.org/10.4103/ijnm.IJNM_77_17; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672767; PMCID: PMC5672767; PMID: 29142363; PUBLISHER-ID: IJNM-32-365; OAI: oai:pubmedcentral.nih.gov:5672767; Copyright: (c) 2017 Indian Journal of Nuclear Medicine; This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Indian Journal of Nuclear Medicine; ISSN 0972-3919;
; v. 32(4); p. 365-366

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[en] Authors have observed a rare case of adenoameloblastoma in panagram and topographic occlusal film of the maxillary anterior region of 15 year old female and obtained the following conclusions: 1. Adenoameloblastoma commonly occurred in lst and 2nd decade of life. 2. The incidence of the lesion is higher in the female than in the male. 3. The incidence of the lesion is higher in the maxilla(especially canine region) than in the mandible. 4. The tumor is often related to an unerupted tooth. 5. The tumor resembled adentigerous cyst but calcified bodies and clusters appeared in the cystic cavity that showed radiopaque in the roentgenograms
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17 refs, 2 figs
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Journal Article
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Korean Journal of Oral and Maxillofacial Radiology; ISSN 1229-8212;
; v. 3(1); p. 43-46

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[en] Approximate sagittal CT sectioning added to transverse CT may provide useful supplementary information of sellar and parasellar lesions. (Auth.)
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Journal Article
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Acta Radiologica. Diagnosis; ISSN 0567-8056;
; v. 19(6); p. 918-920

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