[en] The cephalosporin antibiotic cephalotin has the ability to prolong and intensify the chemiluminescence derived from the cobalt(II)-luminol-hydrogen peroxide system. This is believed to result from the formation of a peroxide complex of cephalotin which is longer lived than the superoxide ion in aqueous solution. It can be used as the basis for the determination of cephalotin in the range of 0.4-400 μg ml^-1. (author). 11 refs.; 1 fig

No abstract available

No abstract available

[en] Irradiation with I Mrad did not have any significant effect on the physicochemical or biological properties of the antibiotics Mycoheptane, Levorin, and amphotericin B. Increasing the dose to 5 Mrads or more led to considerable destruction of the preparations studied. (author)

[en] Published in summary form only

[en] Chemiluminescence is found to be generated by action of lucigenin or hexacyanoferrate(III) on tetracyclines. The reaction with lucigenin exhibits chemiluminescence after alkaline degradation of tetracyclines to the corresponding iso derivatives. The reaction with hexacyanoferrate (III) occurs after acidic degradation of tetracyclines to corresponding anhydro derivatives. The chemiluminescence reaction takes place in alkaline medium, and allows the development of a continuous-flow method for the determination of 1.00-10.0 μgml^-1 oxytetracycline and doxycycline. When applied to commercial formulations, the procedure was relatively free from interferences from common excipients. The results obtained for the assay of dosage forms compared well with those obtained by the official methods and demonstrated good accuracy and precision. (author). 32 refs.; 5 figs.; 6 tabs

[en] Radiologic findings of 81 cases of acute, primary pneumonia in adolescence (in the twenties) were analyzed retrospectively with regard to their pattern, location, evolution and complication. The results were as follows: 1. The cases of single lesion were 85%, and multiple lesion 15%. 2. Left lower lobe was the most frequent site of involvement (42%), followed by right lower lobe (29%), right middle lobe (13%), left upper lobe (12.5%) and right upper lobe (4%) in the cases of single lesion. In cases of multiple lesions, lower lobe involvement was not so predominant as in cases of single lesion. 3. Most of the lesions were alveolar or bronchopneumonic in radiologic pattern. Interstitial pneumonic pattern was found in only 7 cases (9%). 4. Pleural effusion as associated finding was found in only 2 cases (2%). 5. Rapid radiographic improvement, short clinical course, complete healing, without residue when treated with broad spectrum antibiotics seem to be different findings as compared with secondary or elder group pneumonia

[en] As part of their studies into the feasibility of using radiation in the pharmaceutical industry for the purpose of sterilization or lowering the level of microbiological contamination, the author have conducted experiments with 50 kinds of pharmacological products including 40 types of raw materials and 10 types of preparations (mainly ointments) and model formulae. The samples studied may be grouped as follows: effective substances (glucocorticoids, antibiotics, etcor); biochemical products; auxiliary materials used in ointments, tablets, etc.; ointments, primarily those used in ophthalmology. Physical, chemical, and, in some cases, biochemical factors were considered in relation to radiation tolerance. Most of the samples were also subjected to detailed microbiological study. It is concluded that radiosterilization is a promising method as regards the products investigated. (auth.)

[en] The radiosensitivity of 520 microbial strains isolated from the antibiotic preparations Levorin, Mycoheptane, and amphotericin B was studied. The D₁₀ did not exceed 90 Krads for 85 percent of the strains. The most resistant were Bac. subtilis spores, their D₁₀ being 140-200 Krads. (author)

[en] Objectives: To compare the in vitro activities of vancomycin and linezolid against methicillin resistant Staphyloccus aureus in our set up to help in formulating a better empirical treatment and reduce the emergence of vancomycin resistant Staphylococcus aureus. Methods: The study was conducted over a period of 6 months(July 1, 2009 - Dec 1, 2009). Fifty Methicillin resistant Staphylococcus aureus isolated from the clinical isolates of Military Hospital Rawalpindi were subjected to the determination of Minimum inhibitory concentrations of linezolid and vancomycin using E-strips. Results: All the isolated organisms were uniformly susceptible to both the antibiotics. Vancomycin showed higher minimum inhibitory concentrations (MICs) as compared to linezolid MICs. Conclusion: This study suggests that linezolid and vancomycin have similar in vitro efficacy for methicillin resistant Staphyloccus aureus infections. (author)