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Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.
The synthesis and biological activity of some bile acid derivatives2000
The synthesis and biological activity of some bile acid derivatives2000
AbstractAbstract
[en] In this chapter of book authors made conclusion that developed synthesis methods can be used at receiving new bile acids derivatives and they can find use as medical products in particular as preparations diluent gall-cholesteric stones
Original Title
Issledovanie preparatov, rastvoryayushih holesterinovie kamni jelchnogo puzirya i jelchnih protokov
Primary Subject
Source
Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.; Tajik State Medical University, Institute of chemistry(Tajikistan); 193 p; 2000; p. 105-110; Available from the library of Academy of Sciences of the Republic of Tajikistan
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Book
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Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.
The synthesis and biological activity of some bile acid derivatives2000
The synthesis and biological activity of some bile acid derivatives2000
AbstractAbstract
[en] In the present work was worked out and inculcated in production conditions the receiving technology of cholic acid from the bile of cattle which give a possibility of using more available initial raw materials for the synthesis of different derivatives others bile acids
Original Title
Zaklyuchenie
Primary Subject
Source
Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.; Tajik State Medical University, Institute of chemistry(Tajikistan); 193 p; 2000; p. 169-173; Available from the library of Academy of Sciences of the Republic of Tajikistan
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Book
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AbstractAbstract
[en] The farnesoid X receptor (FXR) is a bile acid/alcohol-activated nuclear receptor that regulates lipid homeostasis. Unlike other steroid receptors, FXR binds bile acids in an orientation that allows the steroid nucleus A to face helix 12 in the receptor, a crucial domain for coactivator-recruitment. Because most naturally occurring bile acids and alcohols contain a cis-oriented A, which is distinct from that of other steroids and cholesterol metabolites, we investigated the role of this 5β-configuration in FXR activation. The results showed that the 5β-(A/B cis) bile alcohols 5β-cyprinol and bufol are potent FXR agonists, whereas their 5α-(A/B trans) counterparts antagonize FXR transactivation and target gene expression. Both isomers bound to FXR, but their ability to induce coactivator-recruitment and thereby induce transactivation differed. These findings suggest a critical role for the A orientation of bile salts in agonist/antagonist function
Primary Subject
Source
S0006-291X(05)02541-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 339(1); p. 386-391

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Monks, R.; Riley, A.L.M.
Radiochemical Centre Ltd., Amersham (UK)1981
Radiochemical Centre Ltd., Amersham (UK)1981
AbstractAbstract
[en] This invention relates to the investigation of body function, especially small bowel function but also liver function, using bile acids and bile salts or their metabolic precursors labelled with radio isotopes and selenium or tellurium. (author)
Primary Subject
Source
8 Jul 1981; 18 p; GB PATENT DOCUMENT 1592792/A/
Record Type
Patent
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AbstractAbstract
[en] Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is reported. Antibody titers have uniformly increased over titers used in tritium-based assays; some antibodies are usable in dilutions of 1 : 80,000. The radioimmunoassay described here was found to measure predominantly the primary conjugated bile salts. Sensitivity has been maintained, with the least detectable amount being 0.5 pmoles per assay tube. Normal values in human serum are 3.47 +- 2.16 (SD) nmoles per ml
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Record Type
Journal Article
Journal
Gastroenterology; v. 72(2); p. 305-311
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BODY FLUIDS, CARBOXYLIC ACIDS, DAYS LIVING RADIOISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, HYDROGEN ISOTOPES, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, LIGHT NUCLEI, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, RADIOISOTOPES, STEROIDS, STEROLS, TRACER TECHNIQUES, YEARS LIVING RADIOISOTOPES
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Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.
The synthesis and biological activity of some bile acid derivatives2000
The synthesis and biological activity of some bile acid derivatives2000
AbstractAbstract
[en] For carrying out of biological investigations on studying of diluent ability of synthesized by authors compounds it was necessary to determine the containing bile acids in bile and in blood serum by method of gas-liquid chromatography
Original Title
Opredelenie soderjaniya jelchnih kislot v jelchi metodom gazo-jidkostnoy hromatografii
Primary Subject
Source
Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.; Tajik State Medical University, Institute of chemistry(Tajikistan); 193 p; 2000; p. 118-158; Available from the library of Academy of Sciences of the Republic of Tajikistan
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Book
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AbstractAbstract
[en] The secretion of 14C-labelled t-butyloxycarbonyl glycine-pentagastrin (BOC-GPG) into the bile was studied in rats. BOC-GPG secretion was proportional to the administered dose, it dod not depend on bile acids but it was inhibited by cholephilic organic anions. BOC-GPG by itself influenced neither the flow nor the composition of the bile. (L.E.)
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Journal Article
Journal
Acta Medica Academiae Scientiarum Hungaricae; ISSN 0001-5989;
; v. 38(4); p. 373-380

Country of publication
ANIMALS, BIOLOGICAL MATERIALS, BODY, BODY FLUIDS, CARBON COMPOUNDS, CARBOXYLIC ACIDS, CLEARANCE, DIGESTIVE SYSTEM, GLANDS, HORMONES, HYDROXY COMPOUNDS, KINETICS, MAMMALS, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, PEPTIDE HORMONES, PEPTIDES, POLYPEPTIDES, PROTEINS, RODENTS, STEROIDS, STEROLS, VERTEBRATES
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AbstractAbstract
[en] The bile to plasma 125I-albumin concentration ratio (B/P ratio) was examined before and during various bile salt infusions in male Wistar rats that had previously received iv injection of 125I-albumin. Endogenous rat albumin and IgG concentrations in the bile were also determined by a single radial immunodiffusion method. Taurocholate (TC) infusion (1.0 mumol/min/100 g body wt) significantly increased the bile flow rate in the first hr but the flow began to decline in the second hr. The B/P ratio as well as rat albumin (and IgG) excretion into the bile significantly increased as early as 15 min after the start of TC infusion, and the increase became more pronounced in the second hr, when the bile flow began to decrease. Infusion of taurochenodeoxycholate (TCDC, 0.4 mumol/min/100 g) caused a reduction in bile flow 15 min after the start of infusion but the B/P ratio increased 40 times at its peak compared with the basal value before the bile salt infusion. Simultaneous infusion of tauroursodeoxycholate (TUDC, 0.6 mumol/min/100 g) and TCDC not only abolished the cholestasis induced by TCDC but maintained stable choleresis as long as for 2 hr. During this choleretic period, the B/P ration never exceeded the basal value. The choleresis induced by either taurodehydrocholate (TDHC) or bucolome was not accompanied by enhanced albumin excretion. In rats given TDHC infusion, albumin excretion started to increase only after the bile flow began to decline following the initial choleretic period. The enhanced excretion of albumin induced by TC and TCDC is therefore suggested to be caused not by the choleresis per se but by a possible concomitant increase in the communication between sinusoids and bile canaliculi, which eventually leads to cholestasis
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Journal Article
Journal
Research Communications in Chemical Pathology and Pharmacology; ISSN 0034-5164;
; CODEN RCOCB; v. 65(3); p. 373-388

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ANIMALS, BETA DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BODY FLUIDS, CARBOXYLIC ACIDS, DAYS LIVING RADIOISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, MAMMALS, MATERIALS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, PROTEINS, RADIOISOTOPES, RODENTS, STEROIDS, STEROLS, VERTEBRATES
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AbstractAbstract
[en] The bile acid taurocholate increases the biliary excretion of organic anions, such as sulfobromophthalein (BSP), bilirubin and iopanoic acid. In the present study has been investigated the effect of taurocholate on 1. Canine biliary excretion and concentration of the i.v. contrast medium ioglycamide and 2. Canine bile flow. The experimental model consisted of cholecystectomized, anaesthetized dogs with a fistula, through which the common bile duct could be catheterized and drained. One hour after cannulation, i.v. infusion of ioglycamide at a rate of 4 μmol/min./kg. was started. Two hours after the infusion start a control group received i.v. infusion of saline, while in another a 1.5% sodium taurocholate infusion was started with stepwise increases with 30 min. intervals from 0.4 to 0.8, 1.6 and 3.2 μmol/min./kg. Compared with control, all rates of taurocholate infusion increased bile flow and decreased biliary ioglycamide concentration. Although the bile flow with increasing taurocholate infusion rates was enhanced, the biliary ioglycamide excretion did not increase. The results indicate that ioglycamide and taurocholate are excreted into bile by separate excretion mechanisms. As taurocholate increases the biliary excretion of some other organic anions, it supports the hypothesis that organic anions are excreted into bile by more than two excretion mechanisms, taurocholate affecting only some of them. (orig.)
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Journal Article
Journal
European Journal of Radiology; ISSN 0720-048X;
; v. 3(2); p. 163-166

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ACETAMIDE, AMIDES, ANIMALS, BENZOIC ACID, BIOLOGICAL MATERIALS, BODY FLUIDS, CARBOXYLIC ACIDS, CLEARANCE, CONTRAST MEDIA, DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM, ETHERS, HYDROXY COMPOUNDS, MAMMALS, MATERIALS, MEDICINE, MONOCARBOXYLIC ACIDS, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC IODINE COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC OXYGEN COMPOUNDS, STEROIDS, STEROLS, VERTEBRATES
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AbstractAbstract
[en] [3beta-3H]-bile acids and bile alcohols may be useful for metabolic studies in man and animals because the 3-position is invulnerable to bacterial attack. A number of tritium labeled bile acids and bile alcohols were prepared by selective oxidation of the hydroxyl group at carbon-3 followed by reduction with NaBT4. In each case, the bile acids and bile alcohols epimeric at carbon-3 were resolved by analytical and preparative thin-layer chromatography and characterized by gas liquid chromatography. The average yield was 60 to 65% and specific activities of the final products were in the range of 7.4 x 107 dpm/mg
Record Type
Journal Article
Journal
Steroids; ISSN 0039-128X;
; v. 34(3); p. 259-272

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