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Strand, J.A.; Roesijadi, G.; Emery, R.M.
Pacific Northwest Laboratory annual report for 1977 to the DOE Assistant Secretary for Environment. Part 21978
Pacific Northwest Laboratory annual report for 1977 to the DOE Assistant Secretary for Environment. Part 21978
AbstractAbstract
[en] It is conceivable, and possible, that with increasing applications of nuclear energy, greater quantities of potentially harmful radionuclides will be released to the environment. This may be particularly true for advanced reactor designs such as the fusion reactor where radionuclides, principally tritium, may be expected to escape from the plant both in gaseous and liquid effluents in quantities significantly greater than for present PWR or BWR designs. Foreseeing such contingencies, the research programs described herein are in response to the need to measure the potential radiation effects of tritium releases on individuals, and ultimately populations and biotic communities. As a first approach, our efforts are directed to determine effects of low-level chronic exposures on developing embryo and larval stages, clearly the most radiosensitive. The anticipated increase in the release of beryllium and lithium from mining, refining, and fabrication of materials used during construction of fusion reactors has also caused concern as to potential adverse effects on the environment. Accordingly, FY-78 fusion related research will include efforts to study the metabolism of each metal in the living organism, and to determine at what levels toxicity may be expected. Fusion related research will also include preliminary experiments on the effects of low-level magnetic fields. It is conceivable that magnetic fields of 70 to 450 gauss will be encountered by attendant personnel working in the transport and hot cell areas of fusion reactors. Also, those personnel assigned to the areas immediately surrounding the reactor may be exposed
Original Title
Potential health hazards of fusion reactors
Primary Subject
Source
Vaughan, B.E.; Battelle Pacific Northwest Labs., Richland, WA (USA); p. 3.1-3.6; Feb 1978; p. 3.1-3.6
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Report
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Progress Report
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Volkova, Polina Yu.; Geras'kin, Stanislav A., E-mail: volkova.obninsk@gmail.com2018
AbstractAbstract
[en] Highlights: • ‘Omic’ technologies are appropriate tools for radioecological research. • Systems biology methods can facilitate field radioecological studies. • Fast revealing of mode of action and adverse outcome pathways. - Abstract: This article presents a brief review of the modern ‘omic’ technologies, namely genomics, epigenomics, transcriptomics, proteomics, and metabolomics, as well as the examples of their possible use in radioecology. For each technology, a short description of advances, limitations, and instrumental applications is given. In addition, the review contains examples of successful use of ‘omic’ technologies in the assessment of biological effects of pollutants in the field conditions.
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S0265931X17310366; Available from http://dx.doi.org/10.1016/j.jenvrad.2018.04.011; © 2018 Elsevier Ltd. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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AbstractAbstract
No abstract available
Original Title
Alteracao da microcirculacao em peixes pela acao de metal pesado
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36. Annual Meeting of the Brazilian Society for the Advancement of Science; Sao Paulo, SP (Brazil); 4-11 Jul 1984; Published in summary form only.
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Journal Article
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Conference
Journal
Ciencia e Cultura. Suplemento; ISSN 0102-2474;
; v. 36(7); p. 754

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AbstractAbstract
[en] Endothelial cells (EC) in tumor and normal tissue constitute critical radiotherapy targets. MicroRNAs have emerged as master switchers of the cellular transcriptome. Here, we seek to investigate the role of miRNAs in primary human dermal microvascular endothelial cells (HDMEC) after ionizing radiation. The microRNA status in HDMEC after 2 Gy radiation treatment was measured using oligo-microarrays covering 361 miRNAs. To functionally analyze the role of radiation-induced differentially regulated miRNAs, cells were transfected with miRNA precursor or inhibitor constructs. Clonogenic survival and proliferation assays were performed. Radiation up-regulated miRNA expression levels included let-7g, miR-16, miR-20a, miR-21 and miR-29c, while miR-18a, miR-125a, miR-127, miR-148b, miR-189 and miR-503 were down-regulated. We found that overexpression or inhibition of let-7g, miR-189, and miR-20a markedly influenced clonogenic survival and cell proliferation per se. Notably, the radiosensitivity of HDMEC was significantly influenced by differential expression of miR-125a, -127, -189, and let-7g. While miR-125a and miR-189 had a radioprotective effect, miR-127 and let-7g enhanced radiosensitivity in human endothelial cells. Our data show that ionizing radiation changes microRNA levels in human endothelial cells and, moreover, exerts biological effects on cell growth and clonogenicity as validated in functional assays. The data also suggest that the miRNAs which are differentially expressed after radiation modulate the intrinsic radiosensitivity of endothelial cells in subsequent irradiations. This indicates that miRNAs are part of the innate response mechanism of the endothelium to radiation
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Available from http://dx.doi.org/10.1186/1748-717X-5-25; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859352; PMCID: PMC2859352; PUBLISHER-ID: 1748-717X-5-25; PMID: 20346162; OAI: oai:pubmedcentral.nih.gov:2859352; Copyright (c)2010 Wagner-Ecker et al; licensee BioMed Central Ltd.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Radiation Oncology (Online); ISSN 1748-717X;
; v. 5; p. 25

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External URLExternal URL
AbstractAbstract
No abstract available
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Congress on climate change: Global risks, challenges and decisions; Copenhagen (Denmark); 10-12 Mar 2009; Available from http://dx.doi.org/10.1088/1755-1307/6/20/202023; Abstract only; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Conference
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IOP Conference Series: Earth and Environmental Science (EES); ISSN 1755-1315;
; v. 6(20); [2 p.]

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Wang, Tuoyi; Liu, Yang; Liu, Huazhen; Li, Chunyan; Wang, Yan, E-mail: wangtuoyi@hotmail.com, E-mail: pitwang@163.com2018
AbstractAbstract
[en] Highlights: • Auriculasin regulates dopamine secretion through per1b. • Auriculasin shows good therapeutic indexes on hyperactive behavior in zebrafish. • Auriculasin have potential therapeutic indexes on ADHD. Previously, period1b−/− zebrafish mutants were used to establish an attention deficit hyperactivity disorder (ADHD) model, in which hyperactive behavior was found to be a typical characteristic of ADHD due to down-regulated dopamine levels. Here, we used five prenylated isoflavones from Flemingia philippinensis roots to study their therapeutic effects on hyperactivity behavior in period1b−/− zebrafish. Results of locomotor activity assay showed that auriculasin, one of the prenylated isoflavones, significantly reduced the hyperactivity behavior in period1b−/− zebrafish. Hormone measurement results showed that auriculasin increased melatonin and dopamine content. Results of quantitative real-time polymerase chain reaction showed that auriculasin down-regulated the expression of mao but up-regulated the expression of th and per1b. Thus, auriculasin demonstrated a potential biological effect on dopamine activity to inhibit hyperactivity behavior in the ADHD zebrafish model by regulating circadian clock gene per1b.
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S0006291X18315286; Available from http://dx.doi.org/10.1016/j.bbrc.2018.07.033; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 503(3); p. 1254-1259

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AMINES, AROMATICS, AUTONOMIC NERVOUS SYSTEM AGENTS, AZAARENES, AZOLES, CARDIOTONICS, CARDIOVASCULAR AGENTS, DRUGS, ENZYMES, HETEROCYCLIC COMPOUNDS, HYDROCARBONS, HYDROXY COMPOUNDS, INDOLES, NEUROREGULATORS, NUCLEOTIDYLTRANSFERASES, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PHENOLS, PHOSPHORUS-GROUP TRANSFERASES, POLYPHENOLS, PROTEINS, PYRROLES, SYMPATHOMIMETICS, TRANSFERASES, TRYPTAMINES
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AbstractAbstract
[en] Published in summary form only
Original Title
Fontes alternativas de fosforo para ruminantes
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Castro Arezzo, B. de; Cervellini, A.; Menegassi, J.; Comissao Nacional de Energia Nuclear, Rio de Janeiro, RJ (Brazil). Coordenadoria de Aplicacao de Tecnicas Nucleares; 74 p; Jul 1989; p. 44; Available from the Library of the Comissao Nacional de Energia Nuclear, RJ, Brazil
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Miscellaneous
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AbstractAbstract
[en] Heparin causes a rise in free thyroxine (FT4) measured by equilibrium dialysis (E.D.). With the introduction of at least 4 commercial radioimmunoassays (RIA) for FT4, FT4 measurements have become accepted as one of the best routine thyroid function tests. Investigators have indicated that FT4 levels determined by RIA may be of particular value in patients hospitalized for various severe nonthyroidal illnesses in whom conventional thyroid function tests tend to be abnormal. However, very little information is as yet available on possible effects of various drugs on FT4 levels measured by these new methods. A study was undertaken to evaluate the effect of heparin on FT4 measured by 2 different RIA procedures: RIA-I, GammaCoat FT4 by clinical Assays and RIA-II, Amerlex FT4 by Amersham
Primary Subject
Source
Raynaud, C. (ed.); 542 p; ISBN 0-08-026405-0;
; 1983; v. 4 p. 3379-3382; Pergamon Press; Paris (France); 3. World congress of nuclear medicine and biology; Paris (France); 29 Aug - 2 Sep 1982

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Book
Literature Type
Conference
Country of publication
AMINES, AMINO ACIDS, ANTICOAGULANTS, CARBOHYDRATES, CARBOXYLIC ACIDS, DRUGS, HEMATOLOGIC AGENTS, HORMONES, ISOTOPE APPLICATIONS, MUCOPOLYSACCHARIDES, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC IODINE COMPOUNDS, ORGANIC SULFUR COMPOUNDS, PEPTIDE HORMONES, POLYSACCHARIDES, SACCHARIDES, THYROID HORMONES, TRACER TECHNIQUES
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AbstractAbstract
[en] A retrospective of modern approaches to the synthesis of natural butano- and butenolides based on the use of recent achievements of synthetic organic chemistry is given. For most of the considered compounds, natural sources and biological activities are indicated.
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Available from http://dx.doi.org/10.1070/RC2009v078n04ABEH003899; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Russian Chemical Reviews (Print); ISSN 0036-021X;
; v. 78(4); p. 337-373

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AbstractAbstract
[en] The effects of tritiated water on the development of P. luzonica were determined in terms of the histology of 5 veliger stages using 3 different tritium concentrations, namely, 3.7 Bq/ml, 3.7 x 102 Bq /ml and 3.7 x 104 Bq/ml. An HTO concentration of at least 3.7 x 102 Bq/ml brought about histological abnormalities in the digestive tract in the 5 veliger stages. The structure in the veliger most affected by HTO is the larval stomach. To a lesser degree, differences were found in the larval intestine and stomodaeum. (Auth.). 9 refs.; 10 figs
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