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[en] Particle contamination in a cleanroom is very complex with a complicated process and several pieces of spreading equipment. Detailed information on the locations of the contamination sources and the path of the contamination is needed for economical and efficient control of the contaminant particles in such a cleanroom. An allocation method was developed to quantitatively predict the contamination generated from the pollution sources. In this paper, we propose a zoning method to accelerate the computation time for estimating the contributions. Our results showed that we can quantitatively estimate the amount of contamination generated from pollution sources.
[en] ''Clean Monitor'' is a new method for contamination analysis of gaseous sample. Conventional impinger is widely used to evaluate the contaminant in the air and gases, though the sampling time and detection limits are limited by the loss of the capturing liquid by vaporization. ''Clean Monitor'' is a sampler for very small amounts of contaminants or impurities in clean air and gaseous sample. It is a kind of scrubbing bottle combined with refluxing devices to recover the vapor of capturing liquid. By this method, the sampling time is enabled to be much longer and it is expected the detection limits for contaminants shall be much lower
[en] The aim of this technical report for new Bank-4 clean room of hot cell in RIPF(Radio Isotope Production Facility) is to confirm design values of facility construction for air handling unit system. The company of BUMHO took charge of establishment for this system. This report carried the record of a field measurement conducted by HANA company. The measured values of Bank-4 in this report will be helpful and guidance to management in running facilities
[en] The purpose and scope of this report is to detail the steps necessary for degreasing and cleaning of superconducting RF Niobium cavities in the A0 clean room. It lists the required equipment and the cleaning procedure.
[en] This study is carried out by KAERI(Korea Atomic Energy Research Institute) to construct the basic facilities for development and production of medical radioisotope. For the characteristics of radiopharmaceuticals, the facilities should be complied with the radiation shield and GMP(Good Manufacturing Practice) guideline. The KAERI, which has carried out the research and development of the radiopharmaceuticals, made a design of these facilities and built them in the HANARO Center and opened the technique and facilities to the public to give a foundation for research and development of the radiopharmaceuticals. In the facilities, radiation shielding utilities and GMP instruments were set up and their operating manuals were documented. Every utilities and instruments were performed the test to confirm their efficiency and the approval for use of the facilities will be achieved from MOST(Ministry of Science and Technology). It is expected to be applied in development of therapeutic radioisotope such as Re-188 generator and Ho-166, as well as Tc-99m generator and Sr-89 chloride for medical use. And it also looks forward to the contribution to the related industry through the development of product in high demand and value
[en] Clean room for aseptic production process of radiopharmaceutical kit requires controlled facilities of good environmental condition, particularly the amount of particle and microbiological contamination. In the book of Good Manufacturing Practice (CPOB) the condition of the maximum limitation of particle and microbiological contamination when in non operation and operational has been listed. Therefore, it is necessary to conduct research related to the monitoring of particle and microbiological contamination in the clean room environment. Monitoring of particles and microbiological contamination was conducted at several points in A, B, and C class for 4 batches of production during non operation and operational. Monitoring of microbiological contamination was conducted using Microbial Air Sampler during non operation and (settle plate; contact plate) during operational. The results of monitoring of particle contamination for particle size of 0.5 μm and 5 μm during non operation were A class (19.3 and 0.1), B (92.9 and 0.7), and C (89.9 and 11.4) while operational monitoring of particle size 0.5 μm and 5 μm in A class were 830.5 and 1.5. The average of microbiological monitoring on non operation in A, B, and C class were 0.4; 0.1; 2.4. The average of microbiological monitoring on operational in A, B, and C class were 0.1; 1.4; 2.5 for settle plate and 0.1; 0.0; 0.2 for contact plate. All the particle and microbiological monitoring data obtained showed values below the required maximum. Therefore, it can be concluded that clean room is still feasible to be used for radiopharmaceutical kit production. (author)
[en] With the aim to arrive at procedures allowing the replacement of superconducting cavity main couplers in-situ, three methods to avoid particulate contamination have been tested: a localised and movable clean room named 'Lola', a class 100 clean room and a dynamical confinement method. The results show that contamination by particles normally present in ambient air can be completely avoided by these three methods. As to contamination by particles generated in-situ as a result of human and mechanical interventions, it has been observed that only dynamical confinement can reduce the level of contamination. Clean room and 'Lola' local clean room have not a strong efficiency on this kind of contamination. It was observed that the efficiency of the dynamical confinement method is correlated with the speed of the flow used for the confinement and in our case, a speed of around 1,5 m/s is required to minimise the contamination instead of 0,3 m/s recommended by semiconductor manufacturers. In fact, the particles generated in-situ in large UHV device have higher size and density compared to particles identified in semiconductor clean rooms. (author)
[en] The RIPF(Radio Isotope Production Facility) is the unique facility in Korea which has been used for the isotope production. Through the survey on the radioisotope quantities of production and consumption in the domestic industry, we were trying to show the trend of isotope production. The quantities of Tc-99m, Mo-99, Cr-51, I-131 solution and I-131 capsule produced in the hot cell and clean room of RIPF were compared with the quantities at the previous year. Also the output of the labeling compound such as Hippuran, MIBG, RIHSA, Phytate, MDP, DISIDA, DTPA, etc was compared with the previous year by the radioactivity and the vial. We treated the sum of selling amount of industrial isotopes and tracer isotopes and the status of technical supports also
[en] The correlation of particulate fallout rate with air cleanliness is quite tenuous. Guidelines for predicting fallout rates from air with a known cleanliness have been advanced by Hamberg. The authors have collected fallout and air cleanliness data in a clean, spacecraft integration area to test the applicability of Hamberg's predictive guidelines
[en] The air-filter technology available on the market easily fulfills today's requirements. Until now, production facilities have been provided with a simple encapsulation, either in connection with a cleanroom ceiling, or with their own air-purification system. The encapsulation often consists of simple wall units with access for maintenance. However, the optimal air-flow around the product cannot be achieved with this method. Turbulence is created by such simple encapsulation systems, forming dust-accumulating areas, stagnant air and dead zone areas at processing level. Thus the risk of particle contamination on the product surface is considerably increased. The paper shows ground rules for minienvironment constructions to obtain a less contaminated air-flow at the product level