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Avila, Mario; Morales, J.R.; Riquelme, H.O.
Proceedings of the FEXAP'96: 6. Chilean symposium on experimental and applied physics; EFEX'96: 5. Chilean meeting on education in experimental physics1996
Proceedings of the FEXAP'96: 6. Chilean symposium on experimental and applied physics; EFEX'96: 5. Chilean meeting on education in experimental physics1996
AbstractAbstract
[en] Full text: The natural copper irradiation with deuterons produces the Cu-62, Cu-64 and Cu-66 radionuclides. Of two radioisotopes, those with deficiencies in neutrons, are applied in nuclear medicine diagnostic processes, mainly for the nuclear characteristic of the decay modes. The positron emitters, of short life mean Cu-62 (9.1 min, β+) and Cu(12.7 h), are radionuclides applied in radio pharmacological preparation for brain, core, blood flux studies. The radiochemical process consists in the de solution of the irradiated metallic copper target, in acid medium. The result solution, can be neutralized with a base or a buffer at wished pH. Using a deuteron beam of 4,2 ± 0,1 MeV energy has been obtained total yields of 1,103 ± 0,011 μCl/μAh medium for 62 Cu and of 0,148 ± 0,015 μCl/μAh for 64 Cu
Original Title
Produccion de 62 Cu y 64 Cu con deuterones de 4,2 MeV
Primary Subject
Source
Universidad de la Frontera, Temuco (Chile). Dept. de Ciencias Fisicas; 472 p; 1996; p. 380; FEXAP'96: 6. Chilean symposium on experimental and applied physics; FEXAP'96: 6. Simposio nacional de fisica experimental y aplicada; Temuco (Chile); 9-12 Jan 1996; EFEX'96: 5. Chilean meeting on education in experimental physics; EFEX'96: 5. Encuentro nacional de educacion en fisica experimental; Temuco (Chile); 9-12 Jan 1996; Available from the Library of the Centro de Estudios Nucleares La Reina, Comision Chilena de Energia Nuclear, Casilla 188-D, Amunategui 95, Santiago de Chile
Record Type
Miscellaneous
Literature Type
Conference
Country of publication
BEAMS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, COPPER ISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, ELEMENTS, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ION BEAMS, ISOTOPES, METALS, MINUTES LIVING RADIOISOTOPES, NUCLEAR REACTIONS, NUCLEI, ODD-ODD NUCLEI, RADIOISOTOPES, TARGETS, TRANSITION ELEMENTS
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AbstractAbstract
No abstract available
Primary Subject
Source
Chalupka, A.; Wild, E.; Dirniger, G. (Oesterreichische Akademie der Wissenschaften, Vienna. Inst. fuer Radiumforschung und Kernphysik) (eds.); Oesterreichische Akademie der Wissenschaften, Vienna; 27 p; 1984; p. 16; Published in summary form only.
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Report
Literature Type
Progress Report
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Kang, Choong Mo; Koo, Hyun-Jung; Lee, Sangbin; Lee, Kyo Chul; Oh, Yu-Kyoung; Choe, Yearn Seong, E-mail: ohyk@snu.ac.kr, E-mail: ysnm.choe@samsung.com2013
AbstractAbstract
[en] Introduction: We synthesized and evaluated 64Cu-labeled tetraiodothyroacetic acid (tetrac)-conjugated liposomes for PET imaging of tumor angiogenesis, because tetrac inhibits angiogenesis via integrin αVβ3. Methods: Tetrac-PEG-DSPE and DOTA-PEG-DSPE were synthesized and formulated with other lipids into liposomes. The resulting tetrac/DOTA-liposomes were labeled with 64Cu at 40 °C for 1 h and purified using a PD-10 column. 64Cu-DOTA-liposomes were also prepared for comparison. Human aortic endothelial cell (HAEC) binding studies were performed by incubating the liposomes with the cells at 37 °C. MicroPET imaging followed by tissue distribution study was carried out using U87MG tumor-bearing mice injected with tetrac/64Cu-DOTA-liposomes or 64Cu-DOTA-liposomes. Results: HAEC binding studies exhibited that tetrac/64Cu-DOTA-liposomes were avidly taken up by the cells from 1.02 %ID at 1 h to 11.89 %ID at 24 h, while 64Cu-DOTA-liposomes had low uptake from 0.47 %ID at 1 h to 1.57 %ID at 24 h. MicroPET imaging of mice injected with tetrac/64Cu-DOTA-liposomes showed high radioactivity accumulation in the liver and spleen. ROI analysis of the tumor images revealed 1.93 ± 0.12 %ID/g at 1 h and 2.70 ± 0.36 %ID/g at 22 h. In contrast, tumor ROI analysis of 64Cu-DOTA-liposomes revealed 0.54 ± 0.08 %ID/g at 1 h and 0.52 ± 0.09 %ID/g at 22 h. Tissue distribution studies confirmed that the tumor uptakes of tetrac/64Cu-DOTA-liposomes and 64Cu-DOTA-liposomes were 1.75 ± 0.03 %ID/g and 0.36 ± 0.01 %ID/g at 22 h, respectively. Conclusion: These results demonstrate that tetrac/64Cu-DOTA-liposomes have significantly enhanced tumor uptake compared to 64Cu-DOTA-liposomes due to tetrac conjugation. Further studies are warranted to reduce the liver and spleen uptake of tetrac/64Cu-DOTA-liposomes
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Source
S0969-8051(13)00170-4; Available from http://dx.doi.org/10.1016/j.nucmedbio.2013.08.003; Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
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Leonovicova, T.; Angelis, B.; Cifka, J.; Cifkova, I.
Labelled compounds applied in biochemistry, medicine and biochemical analysis1984
Labelled compounds applied in biochemistry, medicine and biochemical analysis1984
AbstractAbstract
No abstract available
Original Title
Biologicke chovani nekterych chelatu galia
Primary Subject
Source
Ustav pro Vyzkum, Vyrobu a Vyuziti Radioisotopu, Prague (Czechoslovakia); 40 p; 1984; p. 28; 3. national seminar on labelled compounds applied in biochemistry, medicine and biochemical analysis; Srni (Czechoslovakia); 5-8 Nov 1984; Published in summary form only.
Record Type
Miscellaneous
Literature Type
Conference
Report Number
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, COMPLEXES, COPPER ISOTOPES, DAYS LIVING RADIOISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, GALLIUM ISOTOPES, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOTOPES, NUCLEI, ODD-EVEN NUCLEI, ODD-ODD NUCLEI, RADIOISOTOPES
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Chakravarty, Rubel; Chakraborty, Sudipta; Dash, Ashutosh; Guleria, Apurav; Kunwar, Amit; Sarma, Haladhar Dev, E-mail: rubelc@barc.gov.in2018
AbstractAbstract
[en] Synthesis of intrinsically radiolabeled nanoparticles is an emerging concept in cancer theranostics and is expected to play an imperative role in translating nanotechnology research into clinical practice of nuclear medicine. In this study, we have developed a facile protocol for synthesis of small sized (4-5 nm diameter), water soluble, intrinsically radiolabeled 64Cu metal nanoparticles capped within human serum albumin (HSA) scaffold (64Cu- HSA nanocomposite). Detailed characterization of the as-synthesized nanoparticles was carried out by various analytical techniques to establish the colloidal and radiochemical stability, biocompatibility and suitability for clinical administration. The biological efficacy of the intrinsically radiolabeled 64Cu- HSA nanocomposite was demonstrated by biodistribution studies in melanoma tumor bearing C57BL/6 mice, that showed rapid diffusion and accumulation of the radiotracer into tumor and clearance from the biological system by both renal and hepatobiliary routes. The promising results obtained in this study suggest that this strategy could be employed to facilitate clinical translation of a new class of biocompatible radiotracers derived from metalbased nanoparticles for use in cancer theranostics. (author)
Primary Subject
Source
ICRR-HHE 2018: international conference on radiation research - impact on human health and environment and second biennial meeting of society for radiation research: abstracts; Hyderabad (India); 1-4 Feb 2018
Record Type
Journal Article
Literature Type
Conference
Journal
Journal of Radiation and Cancer Research; ISSN 0973-0168;
; v. 9(1); p. 52

Country of publication
ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BLOOD PLASMA, BODY FLUIDS, CARCINOMAS, COPPER ISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, EPITHELIOMAS, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOTOPES, MAMMALS, MATERIALS, NEOPLASMS, NUCLEI, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, PROTEINS, RADIOISOTOPES, RODENTS, VERTEBRATES
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Chakravarty, Rubel; Chakraborty, Sudipta; Ningthoujam, Raghumani Singh
Proceedings of the NAARRI international conference: advanced applications of radiation technology - souvenir2018
Proceedings of the NAARRI international conference: advanced applications of radiation technology - souvenir2018
AbstractAbstract
[en] Synthesis of intrinsically radiolabeled nanoparticles is an emerging concept in cancer theranostics and is expected to play an imperative role in translating nanotechnology research into nuclear medicine industry. In order to reduce reliance on cyclotron produced 64Cu (t1/2 = 12.7 h, EC 45 %, b+ 17.9 %, b- 37.1 %) and increase global accessibility of this radioisotope for preclinical and clinical investigations, we have explored the feasibility of using neutron activated 64Cu produced in research reactors for potential use in cancer theranostics. A viable strategy has been developed for production of 64Cu in medium flux research reactors and its utilization toward industrial-scale (GBq level) synthesis of intrinsically radiolabeled 64CuS nanoparticles (∼ 30 nm particle size). The synthesis procedure was easily executable in a hot cell equipped with suitable remotely operable gadgets and 64CuS nanoparticles could be synthesized in a form suitable for clinical administration. The stability of the nanoparticles under physiological conditions was established by detailed in vitro studies in phosphate buffered saline (PBS) and mouse serum media. The biological efficacy of intrinsically radiolabeled 64CuS nanoparticles was studied in C57BL/6 mice bearing melanoma tumors. The results of the biodistribution studies revealed significant tumor uptake (4.64 ± 1.71 %ID/g) within 4 h postinjection, with good tumor-to-background contrast. Collectively, the promising results obtained in this study suggest that the concept of intrinsically radiolabeled nanoplatforms can be employed to facilitate widespread utilization of neutron activated 64Cu in nuclear medicine industry. (author)
Primary Subject
Source
National Association for Applications of Radioisotopes and Radiation in Industry, Mumbai (India); Department of Atomic Energy, Mumbai (India); International Atomic Energy Agency, Vienna (International Atomic Energy Agency (IAEA)); 230 p; 2018; p. 51; NICSTAR-2018: NAARRI international conference - advanced applications of radiation technology; Mumbai (India); 5-7 Mar 2018
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Book
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Conference
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Nakanishi, C.; Silva, C.P.G. da.
Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)1990
Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)1990
AbstractAbstract
[en] The use of radioisotopes of high specific activity is of great importance in studies on distributions of radioactive substances in living beings. In countries where only low thermal neutron flux reactors are available the production of 64Cu of specific activity is carried out by the Szilard-Chalmers process, which involves the braking of the chemical bondings of the compounds. In this work, experiments were carried out by irradiating the compound bis-[N-benzoil-phenylhydroxylaminate] copper (II) in IEA-R1 nuclear reactor in a thermal neutron flux of 5x1012 n/cm2. Samples without and with thermal treatment before and/or after irradiation were tested. Samples without pre-heating and with thermal annealing were irradiated for 6,5 h and yields of 64Cu of about 3,900 MBq/mg Cu were obtained 21 h after the end of irradiation. The results in this work show the possibility of the preparation of 64Cu of high specific activity with that compound by the Szilard-Chalmers process. The faseability of its production will depend on the optimization of the chemical processing and on the preparation of 64Cu in a suited form for medical applications. (author)
[pt]
O uso de radioisotopos com alta atividade especifica e de grande importancia nos estudos de distribuicao de substancias radioativas em seres vivos. Nos paises que possuem reatores de baixo fluxo de neutrons, a producao de cobre-64 com alta atividade especifica e realizada utilizando-se o processo de ruptura de ligacoes quimicas induzidas por transformacoes nucleares (n,y) conhecida como processo de Szilard-Chalmers. Neste trabalho, realizam-se experimentos irradiando o composto bis -[N-benzol-fenilhidroxilaminato] cobre (II) no Reator Nuclear IEA-R1, em fluxo de neutrons termicos de 5x1012 n/cm2s, utilizando-se amostras sem e com tratamento termico antes e/ou depois da irradiacao. Quando se irradiaram amostras sem pre-aquecimento e com recozimento termico por 6,5 horas obteve-se uma atividade especifica em torno de 3.900 MBq/mg Cu, 21 hs apos a irradiacao. Os resultados obtidos neste trabalho, mostram ser este composto viavel a obtencao de cobre-64, com alta atividade especifica. A sua aplicabilidade dependera da otimizacao do metodo e da preparacao do radiocobre na forma adequada para uso medico. (author)Original Title
Obtencao de Cobre-64 com atividade especifica alta utilizando o processo Szilard-Chalmers
Source
Feb 1990; 11 p
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Report
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AbstractAbstract
[en] The development of a new bifunctional chelator, which holds radio metals strongly in living systems, is a prerequisite for the successful application of disease-specific biomolecules to medical diagnosis and therapy. Recently, TE2A was reported to make kinetically more stable Cu(Π) complexes than TETA. Herein, we report a new synthetic route to TE2A and explore its potential as a bifunctional chelator. TE2A was synthesized using the regioselective alkylation of benzyl bromoacetate and successive de protection of the methylene bridge and benzyl group. Salt-free TE2A was radiolabeled with 64Cu and micro PET imaging was performed to follow the clearance pattern of the 64Cu-TE2A complex. TE2A was conjugated with cyclic RGD peptide and the TE2A-c(RGDyK) conjugate was radiolabeled with 64Cu. TE2A was prepared in salt-free form cyclam in an overall yield of 74%. The micro PET images showed that 64Cu-TE2A is excreted rapidly from the body by the kidney and liver. TE2A was successfully conjugated with c(RGDyK) peptide through on carboxylate group and the TE2A-c(RGDyK) conjugate was radiolabeled with 64Cu in 94% yield within 30 min. TE2A can be used by itself as a bifunctional chelator without any further structural modification.
Primary Subject
Source
35 refs, 5 figs, 1 tab
Record Type
Journal Article
Journal
Nuclear Medicine and Molecular Imaging; ISSN 1975-129X;
; v. 44(3); p. 185-192

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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, COMPUTERIZED TOMOGRAPHY, COPPER ISOTOPES, DIAGNOSTIC TECHNIQUES, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOTOPES, MEDICINE, NUCLEI, ODD-ODD NUCLEI, RADIOISOTOPES, TOMOGRAPHY
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AbstractAbstract
[en] Using a 64Cu complex, we obtained human basal ganglia scans in three normal volunteers and in one patient with Wilson's disease with an oral dose of 1 mCi. The method with this new radioactive compound was simple and safe and the results were very encouraging. (U.S.)
Original Title
64Cu complex
Primary Subject
Record Type
Journal Article
Journal
Journal of Nuclear Medicine; v. 16(8); p. 787-788
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, CENTRAL NERVOUS SYSTEM, COMPLEXES, COPPER ISOTOPES, COUNTING TECHNIQUES, DIAGNOSTIC TECHNIQUES, ELECTRON CAPTURE RADIOISOTOPES, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOTOPES, MEDICINE, NERVOUS SYSTEM, NUCLEAR MEDICINE, NUCLEI, ODD-ODD NUCLEI, ORGANS, RADIOISOTOPE SCANNING, RADIOISOTOPES, TRANSITION ELEMENT COMPLEXES
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AbstractAbstract
No abstract available
Original Title
Spectroscopie gamma sur faisceau de noyau 64Cu; 65Cu(p,pnγ) at 22.25 and 31MeV, 61Ni(α,pγ) at 17.5MeV and 62Ni(α,pnγ) between 25 and 35MeV
Primary Subject
Source
Symposium on nuclear physics with cyclotrons and tandems; Louvain-la-Neuve, Belgium; 27 May 1974; Published in abstract form only.
Record Type
Journal Article
Literature Type
Conference
Journal
J. Phys. (Paris), Colloq; (no.5); p. 2
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