[en] Full text: The natural copper irradiation with deuterons produces the Cu-62, Cu-64 and Cu-66 radionuclides. Of two radioisotopes, those with deficiencies in neutrons, are applied in nuclear medicine diagnostic processes, mainly for the nuclear characteristic of the decay modes. The positron emitters, of short life mean Cu-62 (9.1 min, β⁺) and Cu(12.7 h), are radionuclides applied in radio pharmacological preparation for brain, core, blood flux studies. The radiochemical process consists in the de solution of the irradiated metallic copper target, in acid medium. The result solution, can be neutralized with a base or a buffer at wished pH. Using a deuteron beam of 4,2 ± 0,1 MeV energy has been obtained total yields of 1,103 ± 0,011 μCl/μAh medium for 62 Cu and of 0,148 ± 0,015 μCl/μAh for 64 Cu

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[en] Compounds dinitrato(2-formylpyridinesemicarbazone)copper (I), dichloro(2-formylpyridinesemicarbazone) copper hemihydrate (II), and bis(2-formylpyridinesemicarbazone)copper(2+) perchlorate hydrate (III) are synthesized and their crystal structures are determined. In compounds I-III, the neutral 2-formylpyridine semicarbazone molecule (L) is tridentately attached to the copper atom via the N,N,O set of donor atoms. In compounds I and II, the Cu: L ratio is equal to 1: 1, whereas, in III, it is 1: 2. In complex I, the coordination sphere of the copper atom includes two nitrate ions with different structural functions in addition to the L ligand. The structure is built as a one-dimensional polymer in which the NO₃ bidentate group fulfills a bridging function. The coordination polyhedron of the copper(2+) atom can be considered a distorted tetragonal bipyramid (4 + 1 + 1). Compound II has an ionic structure in which the main element is the [CuLCl₂ . Cu(H₂O)LCl]⁺ dimer. In the dimer, the copper atoms are linked via one of the μ₂-bridging chlorine atoms. The coordination polyhedra of the central atoms of the Cu(H₂)LCl and CuLCl₂ complex fragments are tetragonal bipyramid and tetragonal pyramid, respectively. In compound III, the copper atom is octahedrally surrounded by two L ligands in the mer configuration.

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[en] We have compared, by a differential counting technique, the radioactive decay rates of ⁶⁴Cu atoms in recoil and in lattice sites in β copper phthalocyanine which had been irradiated with neutrons. We see no chemical effect on the rate of decay. A few analogous experiments with α copper phthaloxyanine likewise show no chemical effect on decay, though with some-what larger limits of error. There is also no measurable difference in the decay rate of ⁶⁴Cu in the metal and oxide. (orig.)

[en] The halogen-containing phases of the YBa₂Cu₃O_7-xHal_y (Hal=F, Cl, Br, I) type can be prepared both by high-temperature and low-temperature reactions. An analysis of a large body of experimental evidence indicated that the most interesting and important results are obtained for the low-temperature synthesis of halogenated phases. In the general case, these low-temperature reactions can occur by three mechanisms: i) Incorporation of halogen atoms into the vacant sites of the YBa₂Cu₃O_7-x matrix lattice (for example 05 sites), ii) substitution halogens for the oxygen atoms, iii) intercalation of halogen molecules. The available data suggest that in the low-temperature halogenation of YBa₂Cu₃O_7-x the halogens occupy the sites around the Cu(1) atoms. In the studies of the halogen-containing compounds the most interesting questions are: What are the changes in the coordination for the Cu(1) atoms in the halogenated phases; are there any changes in the charge states of copper and oxygen atoms known to play a key role in the superconducting properties of such phases; what are the effects of changes in the chemical composition of phases on their superconducting and other physical properties? The present work was undertaken with the aim of solving some of such questions. In this study we have chosen the solid-state voltammetry as a method of investigation since the method has been shown to be rather informative for solving such problems. (orig./BHO)

[en] Full text of publication follows. Phenotypic imaging study prior to beta radioimmunotherapy (RIT) is a required step to calculate the dosimetry and to predict the efficacy of RIT. The availability of a radionuclide pair of beta+/beta- isotopes is the optimal solution. It allows an accurate modeling of the radiolabeled immuno-conjugate biodistribution and a good image resolution through PET-CT acquisition. Thereby, 64/67 copper isotopes pair are among the most awaited. Considering copper radiolabelling, the major problem is the in vivo instability of the complex which depends on intricate biological processes - especially trans-chelation to superoxide dismutase and other metalloproteins [Ref.1] - thus in vivo studies are essential to assess the effective potential of a ligand. In this work, we describe a new mono-picolinate cyclam derivative, TEMPA, and demonstrate that its complexation properties and its in vivo behavior are advantageously suitable for copper labeled radiopharmaceuticals. In [Ref.2], it has been previously shown that TEMPA has a high kinetic inertness and an important thermodynamic and electrochemical stability, with cold copper. First, we successfully radiolabeled TEMPA with copper-64 and obtained a quantitative yield in 15 min at room temperature. Second, the in vitro and in vivo stability of the copper-64 complex was assessed. Incubation in human serum performed at both 37 and 4 Celsius degrees has given a complete stability of this complex over 24 hours without any fixation of radioactivity on proteins. Biodistribution, pharmacokinetic and metabolism studies were then conducted in BALC/c mice and compared with a copper-64 acetate as well as a DOTA["6"4Cu"2"+] control group. The TEMPA["6"4Cu"2"+] group has shown a small accumulation of the radioactivity in the liver and kidneys at the early biodistribution time, with an important clearance until the late time. The results of the metabolism study were also very promising, especially in comparison to the DOTA["6"4Cu"2"+] control group, since low trans-chelation was observed in the TEMPA["6"4Cu"2"+] group. References [1] Bioconjug. Chem. 2000 Jul-Aug;11(4):527-32 In vivo trans chelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver [2] Inorg. Chem. 2012 Jun 18;51(12):6916-27 Mono-picolinate cyclen and cyclam derivatives for stable copper(II) complexation. (authors)

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[en] Isotope exchange behaviour of bis(resacetophenone oxime)copper(II) complex with copper(II) in tri-n-butil-phosphate and methanol medium has been studied. The studies were carried out at different temperatures varying the concentration of both metal ion and complex. The results show that the complex is labile in the kinetic sense. Increase in temperature increases the isotope exchange rate. The increase in concentration also results in enhancement of the rate of reaction. (author) 8 refs.; 2 ffigs.; 2 tabs

[en] The calculation of the excited states for 58 to 62 Cu isotopes allowed the effective interaction and formalism of the shell model to be studied