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Liu, Chang; Li, Chao-peng; Wang, Jia-Jian; Shan, Kun; Liu, Xin; Yan, Biao, E-mail: biao.yan@fdeent.org2016
AbstractAbstract
[en] Retinal reactive gliosis is an important pathological feature of diabetic retinopathy. Identifying the underlying mechanisms causing reactive gliosis will be important for developing new therapeutic strategies for treating diabetic retinopathy. Herein, we show that long noncoding RNA-RNCR3 knockdown significantly inhibits retinal reactive gliosis. RNCR3 knockdown leads to a marked reduction in the release of several cytokines. RNCR3 knockdown alleviates diabetes mellitus-induced retinal neurodegeneration, as shown by less apoptotic retinal cells and ameliorative visual function. RNCR3 knockdown could also decrease Müller glial cell viability and proliferation, and reduce the expression of glial reactivity-related genes including GFAP and vimentin in vitro. Collectively, this study shows that RNCR3 knockdown may be a promising strategy for the prevention of diabetes mellitus-induced retinal neurodegeneration. - Highlights: • RNCR3 knockdown inhibits retinal reactive gliosis. • RNCR3 knockdown causes a significant change in cytokine profile. • RNCR3 knockdown alleviates diabetes mellitus-induced retinal neurodegeneration. • RNCR3 knockdown affects Müller glial cell function in vitro.
Primary Subject
Source
S0006-291X(16)31483-8; Available from http://dx.doi.org/10.1016/j.bbrc.2016.09.032; Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 479(2); p. 198-203

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AbstractAbstract
[en] These proceedings on treatment of diabetes mellitus contains a report on diagnosis of lipomatous pancreas in living humans by computerized tomography. refs.; figs.; tabs
Primary Subject
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International Congress Series; no. 726; 1987; 660 p; Excerpta Medica; Amsterdam (Netherlands); 2. International symposium on treatment of diabetes mellitus; Nagoya (Japan); 13-15 Nov 1985; ISBN 0-444-80878-7;
; Contains author and subject index.

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AbstractAbstract
[en] Few data are available on the extent of albuminuria in diabetic populations in the Middle East generally and in Lebanon specifically. We conducted this study to determine the prevalence of albuminuria and its major risk factors in a cohort of diabetic patients in Lebanon. Patients and Diabetic patients followed in the outpatient department at the American University of Beirut Medical Center (AUBMC) were included in a prospective observational study. AUBMC is a tertiary referral center and the outpatient department typically handles patients of low socioeconomic status with advanced disease. Patients were classified according to their urinary albumin-to-creatinine ratio (ACR) as having normoalbuminuria (ACR<30 mg/g creatinine), microalbuminuria (ACR=30 to <300 mg/g creatinine), or macro-albuminuria (ACR 2300 mg/g creatinine). The three groups were compared to analyze the association between albuminuria and its risk factors. In addition, independent predictors of albuminuria were determined using multivariate logistic regression and presented as an odds ratio.Microalbuminuria and macroalbuminuria were present in 33.3% and 12.7% of 222 patients (mean age 56.4 years, mean deviation of diabetes 8.6 years, 58.7% women, 43.8% obese), respectively. Factors significantly associated with microalbuminuria included glycemic control, insulin use, and total and LDL cholesterol.Those associated with macroalbuminuria included in addition to glycemic control and insulin use, duration of diabetes, hypertension, elevated mean arterial pressure (MAP), and presence of neuropathy, retinopathy and peripheral vascular disease by bivariate analysis. Only glycemic control was an independent risk factor for both in addition to MAP and retinopathy for macroalbuminuria by multivariate analysis. Albuminuria is highly prevalent among this cohort of diabetic patients in Lebanon. Both glyce-mic control and blood pressure need to be better targeted in its management (Author).
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Journal Article
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Annals of Saudi Medicine; ISSN 0256-4947;
; v. 28(6); p. 420-425

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AbstractAbstract
[en] A soluble-phase proinsulin assay has been developed which does not require solid-phase antibody-binding. A human proinsulin standard curve is prepared in insulin-free and proinsulin-free plasma for comparison with unknown plasma samples. Proinsulin and insulin are bound with excess anti-insulin antiserum, and free C-peptide is removed by charcoal adsorption. The supernatant is then assayed using a routine C-peptide radioimmunoassay which utilises anti-C-peptide antiserum. The sensitivity of the assay (2 standard deviations above zero) is 9 pmol/L using 200 μL plasma sample. The assay is free from insulin cross-reactivity up to 100 mU/L and C-peptide up to 2000 pmol/L. Between-assay CV is 13% at 100 pmol/L. The assay has been used in subjects with hypoglycaemia of various aetiologies and has shown that a raised plasma proinsulin in the presence of hypoglycaemia can occur in sulphonylurea-induced and reactive hypoglycaemia as well as in insulinomas. After hyperglycaemic clamps at 7.5, 10 and 15 mmol/L glucose, type II diabetics both on and off sulphonylurea, were found to have lower proinsulin concentrations compared with normal subjects, commensurate with the diabetics' lower insulin responses. (author)
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Journal Article
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Czepielewski, M.A.; Abucham Filho, J.; Lengyel, A.M.J.; Kater, C.E.; Chacra, A.R.
Proceedings of the 16. Brazilian Congress of Endocrinology and Metabology1984
Proceedings of the 16. Brazilian Congress of Endocrinology and Metabology1984
AbstractAbstract
No abstract available
Original Title
Diabetes mellitus (DM) na acromegalia: incidencia e fatores de risco em 57 pacientes
Primary Subject
Source
Comissao Organizadora do 16. Congresso Brasileiro de Endocrinologia e Metabologia; 236 p; 1984; p. 165; 16. Brazilian Congress of Endocrinology and Metabology; Canela, RS (Brazil); 27-31 Oct 1984; Published in summary form only.
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Miscellaneous
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Katsumata, K.; Katsumata, Y.; Sakuma, S.; Kaii, O.; Shimamoto, K.; Hirabayashi, N.; Nakagawa, T.
Recent trends in management of diabetes mellitus1987
Recent trends in management of diabetes mellitus1987
AbstractAbstract
[en] Lipomatous pancreas is hardly diagnosed in living humans and usually recognized at autopsy. In the present work, it is proposed that lipomatous pancreas can be diagnosed in living humans by computed tomography (CT) of the pancreas. 2 refs.; 1 figure
Primary Subject
Source
Sakamoto, Nobuo; Hotta, Nigishi (Nagoya Univ. (Japan). School of Medicine); Alberti, K.G.M.M. (Newcastle upon Tyne Univ. (UK). Dept. of Medicine) (eds.); International Congress Series; no. 726; 660 p; ISBN 0-444-80878-7;
; 1987; p. 483-485; Excerpta Medica; Amsterdam (Netherlands); 2. International symposium on treatment of diabetes mellitus; Nagoya (Japan); 13-15 Nov 1985

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Book
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Albano, M.; Hansen, B.C.; Shamekh, R.; Nawang, S.; Tigno, X.T., E-mail: alfonso.albano@gmail.com
31st Annual PAASE Meeting and Symposium: Science and Engineering Education, Research and Innovation Toward National Development and Global Competitiveness2011
31st Annual PAASE Meeting and Symposium: Science and Engineering Education, Research and Innovation Toward National Development and Global Competitiveness2011
AbstractAbstract
[en] Changes in vasomotion may precede other global indices of autonomic dysfunction that track onset and progression of diabetes. Recently we showed that baseline spectral properties of vasomition can discriminate among normoglycemic (N), prediabetic (PreDM), and diabetic (T2DM) nonhuman primates. In this study, our aims were 1. To determine the time-dependence and complexity of the spectral properties of vasomotion in 3 metabolic groups of monkeys; 2. To examine the effects of heat-provoked vasodilatation on the power spectrum; 3. To compare the effects of exogenous insulin on the vasomotion, with and without heat provocation. Laser Doppler flow rates were measured from the foot in 9 N, 11 PreDM, and 7 T2DM monkeys. Baseline flow was measured at 34 °C, and for heating at 44°C. A hyperinuslinemic, euglycemic clamp was performed to produce acute hyperinsulinemia. The Lempel-Ziv complexity, prediction error, and covariance complexity of 5-dimensional embeddings were calculated as measures of randomness. With progression of diabetes, measures of randomness of the vasomotion progressively decreased, suggesting a progressive loss of the homeostatic capacity of the peripheral circulation to respond to environmental changes. Power density among T2DM animals resided mostly in the 0 - 14.5 Hz range, which excluded the cardiac component, suggesting that with progression of the disease, regulation flow shifts towards local rather than central (autonomic) mechanisms. Heating increased all components of the spectral power in all groups. In N, insulin increased the vasomotion contributed by endothelial, neurogenicm vascular myogenic and respiratory processes but diminished that due to heart rate. In contrast, in T2DM, insulin failed to stimulate the vascular myogenic and respiratory activities, but increased the neural/endothelial and heart rate components. Interestingly, acurte hyperinsulinemia resulted in no significant vasomotion changes in the chronically hyperinsulinemic PreDM, suggesting yet another form of ''insulin resistance'' during this stage of disease. (author)
Primary Subject
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Philippine-American Academy of Science and Engineering (PAASE) (Philippines); [vp.]; 2011; [1 p.]; 31. Annual PAASE Meeting and Symposium: Science and Engineering Education, Research and Innovation Toward National Development and Global Competitiveness; Quezon City (Philippines); 15-18 Jun 2011; Available from PNRI Library; Abstract only
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Wang, Wenyi; Wang, Jian; Yan, Meiling; Jiang, Jiechun; Bian, Ailin, E-mail: tuanziguniang@qq.com2018
AbstractAbstract
[en] Highlights: • miRNA-92a could inhibit apoptosis of β cells. • KLF2 as a direct target of miRNA-92a. • miRNA-92a may serve a potential candidate for clinical treatment for DM. diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. However, the relationship between miRNA-92a and pancreatic β cell dysfunction remains unknown. The aim of the study was to investigate the role of miRNA-92a in pancreatic β cell dysfunction.
Primary Subject
Source
S0006291X18308763; Available from http://dx.doi.org/10.1016/j.bbrc.2018.04.097; Copyright (c) 2018 The Authors. Published by Elsevier Inc.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 500(3); p. 577-582

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Shan, Kun; Li, Chao-Peng; Liu, Chang; Liu, Xin; Yan, Biao, E-mail: biao.yan@fdeent.org2017
AbstractAbstract
[en] Retinal microvascular abnormality is an important pathological feature of diabetic retinopathy. Herein, we report the role of lncRNA-RNCR3 in diabetes mellitus-induced retinal microvascular abnormalities. We show that RNCR3 is significantly up-regulated upon high glucose stress in vivo and in vitro. RNCR3 knockdown alleviates retinal vascular dysfunction in vivo, as shown by decreased acellular capillaries, decreased vascular leakage, and reduced inflammatory response. RNCR3 knockdown decreases retinal endothelial cell proliferation, and reduces cell migration and tube formation in vitro. RNCR3 regulates endothelial cell function through RNCR3/KLF2/miR-185-5p regulatory network. RNCR3 inhibition may be a treatment option for the prevention of diabetes mellitus-induced retinal microvascular abnormalities. - Highlights: • RNCR3 expression is significantly up-regulated upon high glucose stress. • RNCR3 knockdown alleviates retinal vascular dysfunction in vivo. • RNCR3 regulates retinal endothelial cell function in vitro. • RNCR3 regulates retinal endothelial cell function via RNCR3/KLF2/miR-185-5p pathway.
Primary Subject
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S0006-291X(16)31984-2; Available from http://dx.doi.org/10.1016/j.bbrc.2016.11.110; Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 482(4); p. 777-783

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AbstractAbstract
[en] An important disease among human metabolic disorders is type 2 diabetes mellitus. This disorder involves multiple physiological defects that result from high blood glucose content and eventually lead to the onset of insulin resistance. The combination of insulin resistance, increased glucose production, and decreased insulin secretion creates a diabetic metabolic environment that leads to a lifetime of management. Appropriate models are critical for the success of research. As such, a unique model providing insight into the mechanisms of reversible insulin resistance is mammalian hibernation. Hibernators, such as ground squirrels and bats, are excellent examples of animals exhibiting reversible insulin resistance, for which a rapid increase in body weight is required prior to entry into dormancy. Hibernator studies have shown differential regulation of specific molecular pathways involved in reversible resistance to insulin. The present review focuses on this growing area of research and the molecular mechanisms that regulate glucose homeostasis, and explores the roles of the Akt signaling pathway during hibernation. Here, we propose a link between hibernation, a well-documented response to periods of environmental stress, and reversible insulin resistance, potentially facilitated by key alterations in the Akt signaling network, PPAR-γ/PGC-1α regulation, and non-coding RNA expression. Coincidentally, many of the same pathways are frequently found to be dysregulated during insulin resistance in human type 2 diabetes. Hence, the molecular networks that may regulate reversible insulin resistance in hibernating mammals represent a novel approach by providing insight into medical treatment of insulin resistance in humans
Primary Subject
Source
Available from http://dx.doi.org/10.1590/1414-431X20122388; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854349; PMCID: PMC3854349; PMID: 23314346; OAI: oai:pubmedcentral.nih.gov:3854349; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Brazilian Journal of Medical and Biological Research; ISSN 0100-879X;
; v. 46(1); p. 1-13

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