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[en] The article deals with main principles of the formation of porous silicon (por-Si) to produce containers for drug delivery systems. Most important por-Si characteristics to produce nanocontainers with required parameters are determined. (paper)
[en] With the evolution of the field of nanomaterials in the past number of years, it has become apparent that it will be key to future technological developments. However, while there are unlimited research undertakings on nanomaterials, limited research results on nanomaterial costs exist; all in spite of the generous funding that nanotechnology projects have received. There has recently been an exponential increase in the number of studies concerning health-related nanomaterials, considering the various medical applications of nanomaterials that drive medical innovation. This work aims to analyze the effect of the cost factor on acceptability of health-related nanomaterials independently or in relation to material toxicity. It appears that, from the materials studied, those used for cancer treatment applications are more expensive than the ones for drug delivery. The ability to evaluate cost implications improves the ability to undertake research mapping and develop opinions on nanomaterials that can drive innovation.
[en] The dispersion of graphene in water has generally been considered an insurmountable challenge owing to its hydrophobic nature. In this study, a new type of light-sensitive polymer/graphene composite (AzoPEO/β-CD–RGO) was synthesized by the reversible host–guest interaction between azobenzene-terminal poly(ethylene oxide) (AzoPEO) and a β-cyclodextrin (β-CD) host attached to the surface of graphene via hydrogen bonding. In water, the AzoPEO/β-CD–RGO composite not only is well dispersed, but also exhibits reversible dispersion/aggregation behavior triggered by UV and visible light. Moreover, the graphene composite can be used to fabricate a light-responsive graphene-based drug delivery system. This kind of light-responsive graphene composite, which efficiently allows the control of graphene dispersion/aggregation, may find wide applications in the preparation of intelligent drug delivery systems, smart sensors, and switching devices.
[en] The antioxidant activity of NH2, OMe, and tert-butyl derivatives of sesamol and their drug delivery with C60 were investigated in gas phase and water. Results show that, C60 can interact with NH2, OMe, and tert-butyl sesamol derivatives and their adsorptions are exothermic and possible from the energetic viewpoint. Results show that, replacing NH2 sesamol derivative has high antioxidant activity and high interactions with C60. Results show that, NH2 and OMe substitutions can increase the antioxidant activity of sesamol. Results show that BDE an IP values of sesamol derivatives and their Ead values have linear dependencies. Calculated results can be used to propose the novel sesamol derivatives with high antioxidant activity.
[en] Gold nanoparticles have been synthesized by use of different volumes of aqueous extract which has been prepared from woman’s tongue tree white flower. The gold nanoparticles and extract were tested for bactericidal qualities on B. subtilis, S. aureus, (Gram positive) and P. aeruginosa, E. coli, (Gram negative) in the concentration range of 0.5 mg ml−1 to 2.0 mg ml−1 using well diffusion. Antibacterial activity shown by all the gold nanoparticles against any of the four organisms was negligible, in spite of the fact that gold nanoparticles are conventionally known to show antibacterial properties. Lack of anti-bacterial properties of gold nanoparticles reported in this paper highlights its inert nature making it a promising alternative for its use in biomedical applications. Given that gold nanoparticles are most suited due to its targeted specificity as well as biocompatibility; these stable gold nanoparticles would be best suited as carriers for drug delivery applications. (paper)
[en] Pretargeted radioimmunoimaging and -therapy approaches building on the bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have yielded impressive results in recent years and have proven a vital alternative to biological pretargeting systems. After improvement of the TCO–antibody conjugates, we here report on our evaluation of a new series of radiolabeled Tz-probes.
[en] We report the synthesis and detailed characterization of intrinsically/lable-free luminescent mesoporous silica nanoparticles (L-MSN), which may have useful biomedical applications. These particles were prepared by modified Stober's method followed by calcination. By optimizing the ratio of (3-aminopropyl triethoxysilane) APTS to tetraetthoxysaline (TEOS), particles with size ~ 43 nm and size dispersion ~ 12% were obtained. The luminescence of L-MSN is suggested to be due to the formation of carbonaceous compounds, giving particles yellowish brown color, during the process of calcination at optimum temperatures ~ 400 °C. Interestingly, our studies suggest that these carbonaceous impurities are carbon dots (C-Dots) and fluorescence anisotropy decay measurements indicate C-Dots as integral part of L-MSN. Luminescent properties of L-MSN were found to be stable as a function of pH as well as long time light exposure. Our results suggest that L-MSN may be explored for biomedical imaging as well as drug delivery applications.
[en] Highlights: • MGO nanocarrier was prepared by loading Fe3O4 on GO sheet. • MGO was observed to be biocompatible having superparamagnetic characteristics. • MGO has showed a very good drug loading performance and pH-responsive release. • Aptamer conjugated MGO was found to be specifically targeting MCF-7 cancer cell.
[en] Highlights: • The synthetic method of [Zn3(BTC)2] using electro- and sonochmistry was compared. • Drug delivery application by employing ibuprofen as drug model was studied. • The sonochemical method (for 30 min) tends to produce nanoscale [Zn3(BTC)2]. • Over 24 h ibuprofen loaded over nano [Zn3(BTC)2] has average release ca. 25.74%. • Unloaded ibuprofen has a faster release ability ca. 85.88% over 24 h.
[en] Scalp imaging techniques are necessary tools for the trichological practice and for visualization of permeation, penetration and absorption processes into and through the scalp and for the research on drug delivery and toxicology. The present letter reviews different scalp imaging techniques and discusses their utility. Moreover, two different studies on scalp imaging techniques are presented in this letter: (1) scalp imaging with phototrichograms in combination with laser scanning microscopy, and (2) follicular measurements with cyanoacrylate surface replicas and light microscopy in combination with laser scanning microscopy. The experiments compare different methods for the determination of hair density on the scalp and different follicular measures. An average terminal hair density of 132 hairs cm−2 was found in 6 Caucasian volunteers and 135 hairs cm−2 in 6 Asian volunteers. The area of the follicular orifices accounts to 16.3% of the skin surface on average measured with laser scanning microscopy images. The potential volume of the follicular infundibulum was calculated based on the laser scanning measurements and is found to be 4.63 mm3 per cm2 skin on average. The experiments show that hair follicles are quantitatively relevant pathways and potential reservoirs for topically applied drugs and cosmetics. (topical review)