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[en]
Background
SOX9, a progenitor cell marker, is important for pancreatic ductal development. Our goal was to examine SOX9 expression differences in intraductal papillary mucinous neoplasms (IPMNs) and ductal adenocarcinoma (PDAC) compared with benign pancreatic duct (BP).Methods
SOX9 expression was evaluated by immunohistochemistry performed on 93 specimens: 37 BP, 24 low grade (LG) IPMN, 12 high grade (HG) IPMN, and 20 PDAC. A linear mixed-effects model was used to compare the percentage of cells expressing SOX9 by specimen type. A separate linear mixed-effects model evaluated differences in SOX9 expression by staining intensity in pancreatic epithelial cells.Results
Nuclear SOX9 expression was detected in the epithelial cells of 98% HG IPMN, 93% LG IPMN, 83% PDAC, and 60% BP. Compared with BP, SOX9 was expressed from a significantly greater percentage of cells in LG IMPN, HG IMPN, and PDAC (p < 0.001 for each). BP and PDAC showed greater variability in SOX9 expression in epithelial cells compared with IPMNs which showed strong, homogenous SOX9 expression in almost all cells. Compared with BP, both LG and HG IPMN showed significantly greater SOX9 expression (p < 0.001 for each), but there was no significant difference in SOX9 expression between LG and HG IPMN (p > 0.05). PDAC had significantly higher expression of SOX9 compared with BP but significantly lower SOX9 expression compared with LG or HG IPMN (p < 0.001 for each).Conclusions
IPMNs demonstrated the highest expression levels of SOX9. SOX9 expression in BP and PDAC demonstrated much more heterogeneity compared with the strong, uniform expression in IPMN.Journal
Annals of Surgical Oncology (Online); ISSN 1534-4681; 
; v. 26(2); p. 628-634
; v. 26(2); p. 628-634
[en] Persistent Mullerian duct syndrome (PMDS) is a rare form of internal male pseudohermaphroditism in which Mullerian duct derivatives are seen in a male patient. This syndrome is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male patient. In this article we present the USG and MRI features of a case of PMDS with bilateral cryptorchidism and left sided inguinal hernia, containing the uterus and fallopian tubes
Journal
Indian Journal of Radiology and Imaging - New Series (Print); ISSN 0971-3026; ; v. 20(1); p. 72-74
; v. 20(1); p. 72-74
[en] Dungeness A was designed and constructed with isolating valves in each main inlet and outlet gas duct. A reconsideration of the possible damage effects which could occur following a variety of postulated burst duct accidents led to a proposal to relocate the actuators, to provide electrical supplies via diverse routes, and to considerably reduce the vulnerability of the drive shafts to damage. The original design features, the uses and weaknesses of the system and the development, installation and testing of the modified system, are described. (U.K.)
Journal
Nucl. Energy; ISSN 0140-4067; ; v. 20(2); p. 201-205
; v. 20(2); p. 201-205
[en] In this article author consider the hypothesis according to meteor bodiesplays important role in the formation of ionospheric-magnetospheric ducts(ducts-ionized channels)
Journal
[en] Lacrimal dacryoscintigraphy facilitates definite diagnosis of obstructions and stenosis of the lacrimal drainage system with little stress to the patient. Together with x-ray dacryocystography it is an important diagnostic tool especially for pre- and postoperative evaluation of the drainage apparatus. Dacryoscintigraphy is the best method for measuring the dynamics of tear drainage especially in the canaliculi. Although it is not a substitute for other methods in general use, it complements them and expands their diagnostic accuracy
Journal
Seminars in Nuclear Medicine; ISSN 0001-2998; ; v. 14(1); p. 8-15
; v. 14(1); p. 8-15
[en] We successfully achieved complete regression of a pancreatic pseudocyst after Ethibloc embolization of a fistula between the cyst and the pancreatic duct. Previous treatment by percutaneous drainage over 6 weeks had failed. Treatment with a somatostatin analog had not been undertaken
Journal
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