[en] Lung lavage has been shown to be an effective method to remove insoluble radionuclides deposited and retained in the lung, but the treatment has been limited to the effective removal of only about 50% of the retained material. Reported here is a change in lavage technique that slightly increases the effectiveness and the addition of high-frequency chest wall oscillation. The latter increased the effectiveness of the lavage procedure but also caused significant physiological complications. (author)

[en] The invention concerns a system consisting of a nuclide generator, transport system, eluting agent container and an eluate container, which are connected to one another by conduits. According to the invention, a tube pump with a control device are used as conveying system enabling the transport of freely chosen amounts of eluate into the eluate container. The tube pump and corresponding conduits are part of the subclaims. (UWI)

No abstract available

[en] Our nuclear pharmacy has reported that a failed radiochemical purity (RCP) (i.e., RCP <90%) of ^99mTc-sestamibi may be associated with the use of a first elution at later stages from a long-ingrowth time (i.e., ≥72 h) wet-column generator. The primary purpose of this study was to evaluate the effects of ^99mTc eluates from wet- and dry-column generators on the RCP of ^99mTc-sestamibi under the above conditions. RCP values were found to be measurably higher and kit failure rates lower with the use of dry-column generator eluate. Using a dry-column generator eluate, Cardiolite[reg] kits were prepared with 11.10 GBq of ^99mTc at 3, 4, and 5 h postelution and 5.55 GBq at 6, 10, 11, and 12 h postelution. Our data suggest that when 11.10 GBq of ^99mTc from a dry-column generator with ≥72-h ingrowth was used to prepare ^99mTc-sestamibi, kit failure started to occur using ^99mTc eluate at approximately 4 h postelution. When 5.55 GBq was used to reconstitute the kit, RCP failure began to occur using ^99mTc eluate ∼ 10 h postelution and was likely to occur by 12 h postelution. Dry-column generator eluates have lower kit failures than do wet-column generators; the failure rate can be reduced even further by avoiding the addition of high activities of ^99mTc and long elution times

No abstract available

[en] Device for eluting nuclide generators comprising a nuclide generator, conveying means, container for eluting agent, and eluate container is described. The container for the eluting agent, the eluate container and the conveying means are connected with the nuclide generator by conduits, the conveying means are mounted between the container for the eluting agent and the eluate container and the conveying means comprise a control mechanism, which permits to convey freely chosen amounts of eluate into the eluate container. (U.S.)

[en] In order to detect the cancer disease, it is particularly interesting to use a radiotracer, the 67 gallium. Indeed, this isotope enjoys the property to be trapped by some cancerous tumours. The isotopic production of the gallium-67 may be obtained by irradation in our cyclotron of zinc, natural or enriched, targets. This production requires especially several conditions concerning the geometry, the purity, the physical and chemical properties. Our experimental research has perfected suitable zinc targets by means of the electrochemistry of various galvanoplastic solutions. The results emphasize the particular interest of hydrogen overvoltage in sulphate solutions. Furthermore, the chemical separation of the zinc and the gallium is carried out by electrochemical oxidizing dissolution and by an anionic absorption flow sheet. (author)

[en] Our nuclear pharmacy noted that ^99mTc-sestamibi kits sometimes failed radiochemical purity (RCP) testing (i.e., RCP < 90%). All failed kits had been prepared with eluate from a newly arrived generator (ingrowth time ≥ 72 h) which had been eluted ≥ 6 h before the kit failure. The effects of ^99mTc activity and eluate volume were then investigated to help explain the reason for the low RCP values. Our results demonstrated that higher failure rates of the ^99mTc-sestamibi kits were noted when higher activities of ^99mTc eluates were added, and the higher failure rates of the kits were associated with lower RCP values. In addition, higher kit failure rate and lower RCP values of the 5.55-GBq kits at 12 h postelution in comparison with the 11.1-GBq kits at 6 h (same eluate volume) indicated that the ^99mTc activity and volume had a less detrimental effect on the ^99mTc-sestamibi kit preparation than the ^99mTc eluate age. The kit failures might be explained by the higher amount of ^99mTc and the production of the free radicals during the long ingrowth time prior to generator elution. In conclusion, the use of a first elution from a long-ingrowth time generator at a later stage (i.e., 11.1 GBq at 6 h and 5.55 GBq at 12 h postelution) in preparation of a ^99mTc-sestamibi kit is associated with a high rate of kit failure and should therefore be avoided

[en] Elution is done by means of an evacuated septum flask. For dosing, a needle with its tip projecting into the elution material container is used, where the depth of penetration can be selected. The setting of the needle is adjustable with reference to its axis, so that the volume of the eluate can be decided. (DG)

[en] Published in summary form only