Results 1 - 10 of 874
Results 1 - 10 of 874. Search took: 0.022 seconds
|Sort by: date | relevance|
[en] A new extremity dosemeter system was developed at GSF, Neuherberg, Germany, serving equally as a partial body dosemeter, consisting of (1) a TL detector sealed in a heat resistant plastic capsule as part of a thin and flexible plastic strip which can also be formed into a ring and closed with a re-usable closing mechanism, (2) automatic PC controlled readout equipment. Advantages are: sterilisable even at autoclave temperatures if unirradiated, high resistance against chemical solvents, permanent identification number, mechanical stability, suitable for wearing in a number of places and easy readout. The readout equipment provides automatic dosemeter evaluation including magazine transport, code detection and heating control. The TL signal is detected by a PMT via a flexible fluid light pipe using a digitally operated photon counting system. The system provides a dose range according to DIN 6816 for extremity dosimetry, and passed the annual quality control by PTB. The prototype system was studied in a field test for six months at different radiological institutions with about 240 users each month. (author)
[en] Temporary stenting and thrombectomy by use of the Solitaire stent (ev3, Irvine, CA, USA) has shown prompt and successful recanalization of the acutely occluded major cerebral artery. However, even if rarely reported, inadvertent stent detachment may occur as an innate drawback and full deployment of the stent was considered to increase the risk. In our patients, the Solitaire stent did not fully unfold to prevent inadvertent detachment. Before retrieval of the stent, the tip of the microcatheter was advanced forward carefully under fluoroscopic observation until it met the presumed thrombus segment and a subtle sense of resistance was felt in the fingers guiding the stent. After retrieval, complete recanalization was achieved, and the thrombus was trapped between the tip of the microcatheter and the stent strut. We present 2 cases of successful thrombi captures by advancing a microcatheter during Solitaire stent retrieval, and we suggest that advancing the microcatheter can be a useful refinement to the thrombectomy technique for acute ischemic stroke
[en] A 39-year-old woman presented with a rapidly growing nodule on the right thumb. An ultrasound study demonstrated a mass located in the deep subcutaneous tissue on the ulnar side of the interphalangeal joint. Incisional biopsy yielded the diagnosis of nodular fasciitis. We discuss the ultrasound appearance of nodular fasciitis as reported in the literature and how to make the differential diagnosis of an echogenic finger mass
[en] To analyze the sonographic findings of clinically diagnosed trigger fingers by comparing those of normal fingers with a special emphasis on findings of the annular pulleys that has not been demonstrated previously. Forty-four fingers of 38 patients with clinically diagnosed trigger fingers and 31 asymptomatic contralateral fingers from 29 patients as the normal control group were included in this study. The mean age of the subjects with trigger fingers was 39 years (age range, 7-74 years; female:male = 32:6) while that of the normal control group, 49 years (age range, 7-74 years; female:male = 24:5). Longitudinal and axial images of the flexor digitorum tendons (FDTs) and adjacent soft tissue were obtained with a careful examination of the annular pulleys including A1 pulley. Two radiologists conducted a retrospective analysis of sonographic findings with an emphasis on the visualization and thickness of annular pulleys, thickness and echo pattern of FDTs, distension of tendon sheath , and presence of ganglion. Statistical significances for the difference of thickness of the annular pulleys and FDTs between patients and normal control group were determined with independent sample t-test. The probability value less than .05 was considered statistically significant. Twenty-six of 44 fingers (59%) showed thickened annular pulleys (A1 in 20 and A3 in 6 cases). The thickness of annular pulleys of control and patient groups was 0.27 ± 0.40 mm and 0.77 ± 85 mm, respectively. The average thickness of FDTs of the control and patient groups were 3.35± 0.77 mm and 3.6 ± 0.9 mm, respectively. The annular pulleys were thickened in the patient group with a statistical significance (p<0.05) whereas the thickness of FDTs did not. The echo pattern of FDTs was normal in 38 fingers of 44 patients (86%) while only six remaining fingers (14%) showed decreased echo and loss of the normal fibrillary pattern within the tendon. Three fingers showed distension of tendon sheath; one finger showed ganglion attached to the tendon sheath. Sonography can clearly demonstrated the presence or absence and the severity of thickening of the annular pulleys in patients with trigger fingers as well as any change of FDTs and other associated findings.
[en] A novel scalable model for multi-finger RF MOSFETs modeling is presented. All the parasitic components, including gate resistance, substrate resistance and wiring capacitance, are directly determined from the layout. This model is further verified using a standard 0.13 μm RF CMOS process with nMOSFETs of different numbers of gate fingers, with the per gate width fixed at 2.5 μm and the gate length at 0.13 μm. Excellent agreement between measured and simulated S-parameters from 100 MHz to 20 GHz demonstrate the validity of this model.
[en] Partial parathyroidectomy (PTX) was carried out 20 times in 15 dialitic patients with chronic renal failure. The operation was suggested by marked radiological abnormalities due to severe secondary hyperparathyroidism, that developed despite aggressive medical and dietetic management. The skeletal x-ray examination showed significant improvement following PTX, that was clearly visible already one month postoperatively at the level of the second and third phalanges of the hands. The improvement of the skeletal osteodystrophic patterns was always associated to a fall of parathyroid hormon and plasma alkaline phosphatase levels. The radiological examination of the hands may represent a usefull and simple method in the follow-up of patients after surgery to assess the efficacy of PTX
[en] Highlights: •RNF38 is shown to be a nuclear protein with a bipartite nuclear localization signal. •RNF38 protein is purified and shown to have ubiquitin protein ligase (E3) activity. •We show that RNF38 binds p53 and can ubiquitinate p53 in vitro. •Overexpression of RNF38 increases p53 ubiquitination in HEK293T cells. •Overexpression of RNF38 in HEK293T cells alters p53 localization. -- Abstract: The RNF38 gene encodes a RING finger protein of unknown function. Here we demonstrate that RNF38 is a functional ubiquitin protein ligase (E3). We show that RNF38 isoform 1 is localized to the nucleus by a bipartite nuclear localization sequence (NLS). We confirm that RNF38 is a binding partner of p53 and demonstrate that RNF38 can ubiquitinate p53 in vitro and in vivo. Finally, we show that overexpression of RNF38 in HEK293T cells results in relocalization of p53 to discrete foci associated with PML nuclear bodies. These results suggest RNF38 is an E3 ubiquitin ligase that may play a role in regulating p53
[en] Hand ischemic steal syndrome due to a forearm arteriovenous fistula is a rare occurrence. However, its frequency is increasing with the rise in numbers of elderly and diabetic patients. This complication, which is more common for proximal than for distal accesses, can be very severe and may cause loss of hand function, damage to fingers, and even amputation of fingers or the hand. Its treatment is difficult and often leads to access loss. We report here a case of severe hand ischemia related to a radiocephalic fistula successfully treated by ulnar artery dilatation.
[en] A retrospective study of the use of radiotherapy in 12 patients with subungual squamous cell carcinoma of the finger was conducted at two radiotherapy departments in the Netherlands. This malignancy has little tendency to metastasize and is usually treated by amputation. Primary radiotherapy resulted in a permanent local control of 92% with only one serious adverse effect leading to an amputation of the initially involved digit. No regional or distant failure was seen during follow-up. Radiotherapy should be considered as an alternative for amputation to treat patients with subungual squamous cell carcinoma of the finger
[en] Full text: Based on the capabilities of new instrumentation and the experience gained in the use of teeth for 'after-the-fact' dosimetry, we have undertaken a systematic electron paramagnetic resonance (EPR) study of irradiated fingernails. There have been only a modest number of previous studies of radiation-induced signals in fingernails. While these have given us some promising aspects, overall results have been inconsistent. The most significant problem of EPR fingernail dosimetry is the presence of two signals of non-radiation origin that overlap the radiation-induced signal (RIS), making it almost impossible to do dose measurements below 5 Gy. Historically, these two non-radiation components were named mechanically-induced signal (MIS) and background signal (BKS). In order to investigate them in detail, three different methods of MIS and BKS mutual isolation have been developed and implemented. Having applied these methods, we were able to understand that fingernail tissue, after cut, can be modeled as a deformed sponge, where the MIS and BKS are associated with the stress from elastic and plastic deformations respectively. A sponge has a unique mechanism of mechanical stress absorption, which is necessary for fingernails in order to perform its everyday function of protecting the fingertips from hits and trauma. Like a sponge, fingernails are also known to be an effective water absorber. When a sponge is saturated with water, it tends to restore to its original shape, and when it looses water, it becomes deformed again. The same happens to fingernail tissue. Our suggested interpretation of the mechanical deformation in fingernails gives also a way to distinguish between the MIS and RIS. Obtained results show that the MIS in irradiated fingernails can be almost completely eliminated without a significant change to the RIS by soaking the sample for 10 minutes in water. This is an ongoing study but even at its present state of development, it has shown that it is quite possible that it will be feasible to use fingernails as an indicator of the severity of radiation exposure in individuals. The findings in this study set the stage for understanding fingernail EPR dosimetry and doing in-vivo measurements in the future. The final goal of this work is to develop an accurate retrospective dosimetry methodology that could be used to determine if potentially exposed populations have received exposures to radiation doses that could be life threatening. (author)