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[en] Substructures similar to those previously reported [1] were observed near an isobaric analogue resonance in 67Ga. The results of an analysis regarding the significance of these substructures against the statistical reaction model are presented. It follows that with a high degree of confidence these substructures are not of statistical origin. (author)
Journal
Revue Roumaine de Physique; ISSN 0035-4090; 
; v. 23(7-8); p. 855-865
; v. 23(7-8); p. 855-865
[en] 67-Ga imaging was performed in 8 treated and 6 untreated patients with documented South American Blastomycosis (paracoccidioidomycosis) confirmed by histology. All patients were male, aged 20-68 years, with evolution of the disease from two months to 18 years. Sorologic tests were performed in 12 patients. 67-Ga images were correlated with X-ray in all patients. The images with 67-Ga showed evidency of lesions unsuspected by clinical examination and missed by X-ray in 9 patients. On the other hand, two cases with clinically diagnosed tegumentar lesions, particularly of the oro-nasal region, were not demonstrated on 67-Ga images. Follow-up studies after specific therapy were done in four patients and demonstrated concordance between X-ray and 67-Ga in two patients with pulmonary involvent; in the other two patients with lymphatic system involvement these studies showed normalization of the 67-Ga images although their sorologic tests persisted positive. This initial evaluation demonstrated that 67-Ga imaging is a useful tool for detection of suspected and, more importantly, unsuspected lesions of paracoccidioidomycosis and for evaluation of the response of the disease to specific therapy. (author)
[pt]
O estudo de imagens com 67-Ga foi realizado em 14 pacientes (oito tratados e seis virgens de tratamento) com blastomicose sul-americana (paracoccidioidomicose) confirmada pela histologia. Todos os pacientes eram masculinos, com idades entre 20 e 68 anos, com evolucao de doenca entre dois meses e 18 anos. A avaliacao sorologica foi efetuada em 12 pacientes. As imagens com 67-Ga foram correlacionadas com o estudo radiologico em todos eles e mostraram evidencias de lesoes nao suspeitadas pelo exame clinico ou nao mostradas pela radiologia em nove casos: parotidas em quatro casos; testiculos em dois; ossos em um; ganglio mediastinal em um e ganglio cervical mediano profundo (que causou obstrucao do ducto toracico) em outro. Em contrapartida, dois casos com lesoes clinicamente evidentes no tegumento (particularmente na regiao oro-nasal) nao foram mostrados no estudo com 67-Ga. No acompanhamento apos tratamento especifico em quatro pacientes, houve concordancia entre os estudos radiologicos e com 67-Ga em dois, com envolvimento pulmonar; em outros dois, com envolvimento ganglionar, houve normalizacao nas imagens com 67-Ga enquanto a sorologia continuava positiva. Esta avaliacao inicial demonstrou que as imagens com 67-Ga sao uteis na deteccao de lesoes suspeitas e, muito mais importante, naquelas insuspeitas da blastomicose, bem como para avaliar a resposta de doenca ao tratamento especifico. (autor)Journal
[en] Sarcoidosis is a multisystemic disease and has diverse presentations which makes the diagnosis a little difficult. Gallium is being used to diagnose active sites of involvement. Whole body can be imaged by gallium scintigraphy using a gamma camera aligned to a moving table and tomographic camera. The purpose of this study is to compare the efficacy of gallium scanning by two whole body scanning techniques in detecting various sites of active sarcoidosis. 4 refs.; 2 tabs
Source
Grassi, C. (Pavia Univ. (Italy). Inst. for Respiratory Disease); Rizzato, G. (Niguarda Hospital, Milan (Italy). Sarcoidosis Clinic); Pozzi, E. (Turin Univ. (Italy). Chair of Pulmonary Physiopathology) (eds.); Int. Congr. Ser; no. 756; 801 p; ISBN 0-444-80983-X; ; 1988; p. 521-522; Excerpta Medica; Amsterdam (Netherlands); 11. World congress on sarcoidosis and other granulomatous disorders; Milan (Italy); 6-11 Sep 1987
; 1988; p. 521-522; Excerpta Medica; Amsterdam (Netherlands); 11. World congress on sarcoidosis and other granulomatous disorders; Milan (Italy); 6-11 Sep 1987
[en] A method is described for 67Ga-labeling liposomes containing a polyethylene glycol coating which exhibit prolonged blood circulation, reduced liver and spleen uptake and accumulation in tumours. Applications as agents for diagnostic imaging and delivery of therapeutic agents are considered. Previous methods were adapted to compensate for the presence of low temperature phase transition phospholipids resulting in consistent loading with low levels of residual unentrapped label. (author)
Journal
[en] Sarcoidosis is a chronic multisystem disorder of unknown etiology characterized by non-caseating epitheloid granulomas. We report a case of a 29-year old female with acute sarcoidosis and Heerfordt's syndrome (parotid enlargement, anterior uveitis and facial nerve palsy) who had a typical clinical constellation but no histologic criteria of a granulomatous inflammatory process in transbronchial lung biopsy. 67Ga scintigraphy revealed such a typical pattern of accumulation that sarcoidosis could be diagnosed despite negative histological findings. (orig.)
[de]
Die Sarkoidose ist eine chronische Systemerkrankung unbekannter Aetiologie, die durch nichtverkaesende epitheloidzellige Granulome gekennzeichnet ist. Wir berichten ueber eine 29jaehrige Patientin mit akuter Sarkoidose und Heerfordt-Syndrom (Parotisschwellung, Iridozyklitis und Fazialisparese), bei der zwar eine typische klinische Befundkonstellation vorlag, die transbronchiale Lungenbiopsie jedoch histologisch keinen granulomatoesen Entzuendungsprozess nachweisen konnte. Die 67Ga-Szintigraphie zeigte ein so typisches Anreicherungsmuster, dass trotz negativer Histologie die Diagnose gestellt werden konnte. (orig.)Journal
No abstract available
Source
Raynaud, C. (ed.); 1141 p; ISBN 0-08-027-090-5; ; 1982; v. 2 p. 1199-1200; Pergamon; Paris (France); 3. World congress of nuclear medicine and biology; Paris (France); 29 Aug - 2 Sep 1982; Published in summary form only.
; 1982; v. 2 p. 1199-1200; Pergamon; Paris (France); 3. World congress of nuclear medicine and biology; Paris (France); 29 Aug - 2 Sep 1982; Published in summary form only.
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