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AbstractAbstract
[en] Cross sections and rate coefficients have been compared for rovibrational transitions between and within the four lowest vibrational states of H2, induced in collisions with H atoms. Our quantal close-coupling calculations are compared with previous classical trajectory Monte Carlo results. At low temperatures, there are large discrepancies, whereas, as the temperature increases, the present and previously computed rate coefficients are found to be in satisfactory agreement. (author)
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Journal Article
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Journal of Physics. B, Atomic, Molecular and Optical Physics; ISSN 0953-4075;
; CODEN JPAPEH; v. 30(13); p. 3009-3017

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AbstractAbstract
[en] Romidepsin is a histone deacetylase inhibitor approved by the FDA for the treatment of patients with cutaneous or peripheral T-cell lymphoma who have received prior systemic therapy. The objective of this analysis was to evaluate the potential QTc effects of romidepsin. Patients with advanced malignancy received 4-h infusions of 14 mg/m2 romidepsin on days 1, 8, and 15 of a 28-day cycle. In cycle 2, a subset of patients received 1-h infusions of 8–12 mg/m2 romidepsin. Patients were administered antiemetics before each romidepsin dose and electrolyte supplementation as needed. Electrocardiogram readings were performed prior to antiemetic administration, prior to romidepsin administration, and at specified time points over the subsequent 24 h. Romidepsin exposure and heart rate were also assessed. In the electrocardiogram-evaluable population, 26 patients received romidepsin at 14 mg/m2 over 4 h. The maximum mean increases from the preantiemetic baseline for QTcF and heart rate were 10.1 msec (upper 90% CI, 14.5 msec) and 18.2 beats per minute, respectively. No patient in this study had an absolute QTcF value >450 msec and only one patient had an increase from the preantiemetic baseline of >60 msec. There was a mild reduction in the PR interval and no meaningful changes in the QRS interval. Despite the use of QT-prolonging antiemetics, treatment with romidepsin did not markedly prolong the QTc interval through 24 h. Increases in calculated QTc may have been exaggerated as a consequence of transient increases in heart rate
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Available from http://dx.doi.org/10.1002/cam4.467; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559029; PMCID: PMC4559029; PMID: 25914207; OAI: oai:pubmedcentral.nih.gov:4559029; Copyright (c) 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.; This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Cancer Medicine; ISSN 2045-7634;
; v. 4(8); p. 1178-1185

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AbstractAbstract
[en] Analysis of the data acquired with the BINA detector system in 1H(d, pp)n reaction at the beam energy of 80 MeV/nucleon makes a systematic analysis of the star configurations possible. This paper shows the preliminary cross section of the Forward-Plane Star (FPS) configuration with the neighbouring configurations. (author)
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Hegland, P.M.; Koepke, J.A.; Lilley, J.S.; Brown, R.E.
John H. Williams Laboratory of Nuclear Physics, University of Minnesota, annual report, 19751975
John H. Williams Laboratory of Nuclear Physics, University of Minnesota, annual report, 19751975
AbstractAbstract
No abstract available
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Minnesota Univ., Minneapolis (USA). John H. Williams Lab. of Nuclear Physics; p. 1-7; Sep 1975
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Report
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Progress Report
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AbstractAbstract
[en] Deuterium diffusion profiles comprising measures of concentration and distance inbound from a deuteride surface layer, for different temperatures and times, were regressed to a diffusivity relation derived from the Einstein flux equation. Diffusion of deuterium in the three principal directions of anisotropic Zr-2.5Nb showed no statistical differences; any effect of discontinuous β-phase on diffusion is within the 20% scatter seen for diffusivity values. Consequently, a single diffusivity relation for hydrogen isotopes in zirconium alloys, comprising mostly alpha phase, was determined by combining diffusivities from this study and previous work for protium, deuterium, and tritium, in Zr-2.5Nb and Zircaloy.
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S0022311518305348; Available from http://dx.doi.org/10.1016/j.jnucmat.2018.08.002; Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
[en] Chemical exchange saturation transfer (CEST) experiments are becoming increasingly popular for investigating biomolecular exchange dynamics with rates on the order of approximately 50–500 s−1 and a rich toolkit of different methods has emerged over the past few years. Typically, experiments are based on the evolution of longitudinal magnetization, or in some cases two-spin order, during a fixed CEST relaxation delay, with the same class of magnetization prepared at the start and selected at end of the CEST period. Here we present a pair of TROSY-based pulse schemes for recording amide and methyl 1H CEST profiles where longitudinal magnetization at the start evolves to produce two-spin order that is then selected at the completion of the CEST element. This selection process subtracts out contributions from 1H–1H cross-relaxation on the fly that would otherwise complicate analysis of the data. It also obviates the need to record spin-state selective CEST profiles as an alternative to eliminating NOE effects, leading to significant improvements in sensitivity. The utility of the approach is demonstrated on a sample of a cavity mutant of T4 lysozyme that undergoes chemical exchange between conformations where the cavity is free and occupied.
Source
Copyright (c) 2018 Springer Science+Business Media B.V., part of Springer Nature; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Journal of Biomolecular NMR; ISSN 0925-2738;
; v. 70(2); p. 93-102

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AbstractAbstract
[en] To test Bell's inequality, measurements of spin correlations between two protons in the spin singlet state have been performed. Proton pairs in the singlet state were produced by the 1H(d,2He)n reaction at Ed = 270 MeV
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19. European conference on few-body problems in physics; Groningen (Netherlands); 23-27 Aug 2004; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
No abstract available
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S0006-291X(12)01516-1; Available from http://dx.doi.org/10.1016/j.bbrc.2012.08.019; Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 425(3); p. 527-533

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AbstractAbstract
[en] The realized target is described; as the necessary ground noise measurements cannot be made on this target a new target is considered, the principal characteristics of which are given
[fr]
La cible est decrite telle qu'elle est realisee; les mesures de bruit de fond necessaires ne pouvant etre faites, une nouvelle cible est envisagee dont les principales caracteristiques sont donneesOriginal Title
Realisation d'une cible d'hydrogene liquide a Saturne
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Laboratoire National Saturne, Centre d'Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France); 748 p; ISBN 2-7272-0085-4;
; 1983; p. 663-666; Commissariat a l'Energie Atomique; Saclay (France); 3. Saturne meeting; Fontevraud (France); 25-29 Apr 1983; Available from Laboratoire National Saturne, CEN Saclay, 91 - Gif-sur-Yvette (France)

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Book
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Mulder, Frans A. A.; Otten, Renee; Scheek, Ruud M., E-mail: f.a.a.mulder@rug.nl, E-mail: r.m.scheek@rug.nl2011
AbstractAbstract
[en] Here we describe phasing anomalies observed in gradient sensitivity enhanced 15N-1H HSQC spectra, and analyze their origin. It is shown that, as a result of 15N off-resonance effects, dispersive contributions to the 1H signal become detectable, and lead to 15N-offset dependent phase errors. Strategies that effectively suppress these artifacts are presented.
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Copyright (c) 2011 Springer Science+Business Media B.V.; Article Copyright (c) 2011 The Author(s); Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Journal of Biomolecular NMR; ISSN 0925-2738;
; v. 51(1-2); p. 199-207

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