Results 1 - 10 of 15844
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[en] Cross sections and rate coefficients have been compared for rovibrational transitions between and within the four lowest vibrational states of H2, induced in collisions with H atoms. Our quantal close-coupling calculations are compared with previous classical trajectory Monte Carlo results. At low temperatures, there are large discrepancies, whereas, as the temperature increases, the present and previously computed rate coefficients are found to be in satisfactory agreement. (author)
[en] Romidepsin is a histone deacetylase inhibitor approved by the FDA for the treatment of patients with cutaneous or peripheral T-cell lymphoma who have received prior systemic therapy. The objective of this analysis was to evaluate the potential QTc effects of romidepsin. Patients with advanced malignancy received 4-h infusions of 14 mg/m2 romidepsin on days 1, 8, and 15 of a 28-day cycle. In cycle 2, a subset of patients received 1-h infusions of 8–12 mg/m2 romidepsin. Patients were administered antiemetics before each romidepsin dose and electrolyte supplementation as needed. Electrocardiogram readings were performed prior to antiemetic administration, prior to romidepsin administration, and at specified time points over the subsequent 24 h. Romidepsin exposure and heart rate were also assessed. In the electrocardiogram-evaluable population, 26 patients received romidepsin at 14 mg/m2 over 4 h. The maximum mean increases from the preantiemetic baseline for QTcF and heart rate were 10.1 msec (upper 90% CI, 14.5 msec) and 18.2 beats per minute, respectively. No patient in this study had an absolute QTcF value >450 msec and only one patient had an increase from the preantiemetic baseline of >60 msec. There was a mild reduction in the PR interval and no meaningful changes in the QRS interval. Despite the use of QT-prolonging antiemetics, treatment with romidepsin did not markedly prolong the QTc interval through 24 h. Increases in calculated QTc may have been exaggerated as a consequence of transient increases in heart rate
[en] Analysis of the data acquired with the BINA detector system in 1H(d, pp)n reaction at the beam energy of 80 MeV/nucleon makes a systematic analysis of the star configurations possible. This paper shows the preliminary cross section of the Forward-Plane Star (FPS) configuration with the neighbouring configurations. (author)
[en] Deuterium diffusion profiles comprising measures of concentration and distance inbound from a deuteride surface layer, for different temperatures and times, were regressed to a diffusivity relation derived from the Einstein flux equation. Diffusion of deuterium in the three principal directions of anisotropic Zr-2.5Nb showed no statistical differences; any effect of discontinuous β-phase on diffusion is within the 20% scatter seen for diffusivity values. Consequently, a single diffusivity relation for hydrogen isotopes in zirconium alloys, comprising mostly alpha phase, was determined by combining diffusivities from this study and previous work for protium, deuterium, and tritium, in Zr-2.5Nb and Zircaloy.
[en] Chemical exchange saturation transfer (CEST) experiments are becoming increasingly popular for investigating biomolecular exchange dynamics with rates on the order of approximately 50–500 s−1 and a rich toolkit of different methods has emerged over the past few years. Typically, experiments are based on the evolution of longitudinal magnetization, or in some cases two-spin order, during a fixed CEST relaxation delay, with the same class of magnetization prepared at the start and selected at end of the CEST period. Here we present a pair of TROSY-based pulse schemes for recording amide and methyl 1H CEST profiles where longitudinal magnetization at the start evolves to produce two-spin order that is then selected at the completion of the CEST element. This selection process subtracts out contributions from 1H–1H cross-relaxation on the fly that would otherwise complicate analysis of the data. It also obviates the need to record spin-state selective CEST profiles as an alternative to eliminating NOE effects, leading to significant improvements in sensitivity. The utility of the approach is demonstrated on a sample of a cavity mutant of T4 lysozyme that undergoes chemical exchange between conformations where the cavity is free and occupied.
[en] To test Bell's inequality, measurements of spin correlations between two protons in the spin singlet state have been performed. Proton pairs in the singlet state were produced by the 1H(d,2He)n reaction at Ed = 270 MeV
[en] The realized target is described; as the necessary ground noise measurements cannot be made on this target a new target is considered, the principal characteristics of which are given
[fr]La cible est decrite telle qu'elle est realisee; les mesures de bruit de fond necessaires ne pouvant etre faites, une nouvelle cible est envisagee dont les principales caracteristiques sont donnees
[en] Here we describe phasing anomalies observed in gradient sensitivity enhanced 15N-1H HSQC spectra, and analyze their origin. It is shown that, as a result of 15N off-resonance effects, dispersive contributions to the 1H signal become detectable, and lead to 15N-offset dependent phase errors. Strategies that effectively suppress these artifacts are presented.