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[en] Highlights: • The neuropathic pain in cervical spondylotic radiculopathy (CSR) is greatly impact the patient's life and work. • The neuropathic pain is partly caused by the inflammation induced by microglia activation. • Overexpression of TUSC7 inhibited microglial activation and the expression of inflammatory factors. • Overexpression of TUSC7 inhibited the inflammation caused by microglia activation via miR-449a up-regulating PPAR-γ. The aim of this study was to investigate the mechanisms of TUSC7/miR-449a/PPAR-γ axis on the inflammation induced by microglia activation.
[en] Idiopathic inflammatory myositis is characterized by rapidly progressive, symmetric weakness of the muscles that produce severe disability. In the majority of these patients, myositis appears to be a paraneoplastic feature associated with cancer. Fluorodeoxyglucose positron emission tomography-computed tomography has been increasingly used in the detection and evaluation of occult malignancy responsible for the paraneoplastic syndromes.
[en] This book describes a novel approach to the scintigraphy of inflammatory processes of the extremities. It presents a method specially developed to bring this diagnostic modality whithin the reach of every nuclear medicine centre without requiring a special infrastructure or extensively trained personnel. The author revieuws the existing nuclear medicine techniques and critically analyses their relative advantages and pitfalls before proceeding to a detailed account of the use of a colloidal tracer for detecting and monitoring inflammation. The author identifies the pathophysiological basis of his concept and gives extensive preclinical data prior to discussing a number of comparative clinical studies with the new technique. Additional benefits are brought by the book's emphasis on the importance of a solid radiopharmacological foundation to the medically used tracers and demonstrates with a few suprising examples how shortcomings at this level may lead to misleading findings in the daily practive of nuclear medicine, even with routinely used radiopharmaceuticals. (author). refs.; figs.; tabs