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Yin, Kai; Dang, Shengchun; Cui, Lei; Fan, Xin; Xie, Rong; Qu, Jianguo; Shang, Mengyuan; Chen, Jixiang, E-mail: shangmy1985@sina.com, E-mail: cyok9@163.com2018
AbstractAbstract
[en] Yes-associated protein (YAP) is a major downstream molecular of the Hippo pathway, which plays important role in cancer development. Netrin-1 conveys oncogenic activity in many types of malignant tumors. However, the downstream signaling of netrin-1 mediating its oncogenic effects in gastric cancer (GC) is not well defined. Here, we aim to investigate the role of netrin-1 in metastasis potential of GC by regulating YAP. In this study, we showed that netrin-1 inhibition significantly decreased migration and invasion abilities of GC cells, while netrin-1 overexpression effectively reversed this effect. We also demonstrated that netrin-1 upregulated YAP expression via its transmembrane receptor neogenin. Furthermore, our in vitro and in vivo results showed that the effect of netrin-1 on GC cells migration and invasion abilities was regulated by YAP. Collectively, our results defined netrin-1 as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy.
Primary Subject
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S0006291X17325822; Available from http://dx.doi.org/10.1016/j.bbrc.2017.12.170; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 496(1); p. 76-82

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AbstractAbstract
[en] In 63 patients with mammary or bronchial carcinoma, 88 painful bone metastases were randomly irradiated with one of two schedules to find out wether a short treatment would give the same palliative effect as a longer scheme does. After evaluation of the reaction of the pain to the irradiation and assesment of the side effects, it was found that a shorter schedule can be equally effective without an increase in the incidence and degree of side effects
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Journal Article
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Journal Europeen de Radiotherapie; ISSN 0243-1203;
; v. 2(2); p. 123-126

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AbstractAbstract
[en] Highlights: • High ZIC5 expression in specimens indicates poor prognosis of HCC patients. • ZIC5 was required in proliferation and tumorigenicity of HCC. • ZIC5 promotes proliferation and tumorigenicity of HCC cells. • ZIC5 promoted growth of HCC in a β-catenin dependant manner. The incidence and mortality of hepatocellular carcinoma (HCC) is high, but the mechanisms underlying the growth and progression of HCC have not been elucidated. Recently, the ZIC family member 5 (ZIC5) is emerging as an oncogene in various types of tumors. However, its expression and biological role in HCC have not been reported. This study first demonstrated that ZIC5 was up-regulated in HCC specimens, and high ZIC5 expression indicated poor prognosis of HCC patients. In addition, over-expressed ZIC5 promoted the proliferation, migration and invasion of HCC cell lines Huh7 and HepG2 in vitro and in vivo, while ZIC5 knockdown achieved the opposite effects. Actually, ZIC5 increased the expression of genes participating in Wnt/β-catenin pathway such as β-catenin and CyclinD1. ZIC5 also promoted β-catenin to enter the nucleus of HCC cells. Furthermore, silencing β-catenin abated the promoting role of ZIC5 in HCC. Overall, this study reveals a novel mechanism of ZIC5/β-catenin that mediates the invasion and metastasis of HCC and ZIC5 serves as a novel indicator for prognosis of HCC patients.
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S0006291X18316826; Available from http://dx.doi.org/10.1016/j.bbrc.2018.08.009; Copyright (c) 2018 Published by Elsevier Inc.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 503(3); p. 2173-2179

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Dellavedova, Luca; Calcagno, Anna; Roncoroni, Lucia; Maffioli, Lorenzo Stefano, E-mail: lorenzo.maffioli@ao-legnano.it2015
AbstractAbstract
[en] The prevalence of bone metastases from colorectal cancer (CRC) is quite low and the presence of isolated osseous metastases at the time of diagnosis or the onset of bone metastases without other organ involvement during follow-up is even lower. Here, we present an interesting case of diffuse skeletal metastases from CRC in which both the atypical presentation of the metastatic spread and the presence of infective comorbidities created some troubles in getting the final diagnosis
Primary Subject
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Available from http://dx.doi.org/10.4103/1450-1147.161726; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564929; PMCID: PMC4564929; PMID: 26420997; PUBLISHER-ID: WJNM-14-219; OAI: oai:pubmedcentral.nih.gov:4564929; Copyright: (c) World Journal of Nuclear Medicine; This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; This record replaces 47118563; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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World Journal of Nuclear Medicine (Online); ISSN 1607-3312;
; v. 14(3); p. 219-221

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Kvapil, F.; Petruzelka, L.; Konopasek, B.; Betka, J.; Zeman, K.; Konecny, L.
V. Czechoslovak radiological congress with international participation1981
V. Czechoslovak radiological congress with international participation1981
AbstractAbstract
No abstract available
Original Title
Radioterapie v komplexni lecbe ca laryngu
Primary Subject
Source
Slovenska Lekarska Spolocnost, Bratislava (Czechoslovakia); 213 p; 1981; p. 107; 5. Czechoslovak radiological congress; Bratislava (Czechoslovakia); 2-3 Sep 1981; Publish in summary form only.
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Miscellaneous
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AbstractAbstract
[en] To analyze the detailed pattern of intraosseous failure after stereotactic body radiation therapy (SBRT) for coxal bone metastasis.
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S0360301617338427; Available from http://dx.doi.org/10.1016/j.ijrobp.2017.08.045; Copyright (c) 2017 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016;
; CODEN IOBPD3; v. 100(1); p. 159-161

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Coupek, P.; Pajdlhauser, R.; Pohankova, R.; Huebnerova, P.
IV. South-Bohemian Oncology Days. Survey of lectures1998
IV. South-Bohemian Oncology Days. Survey of lectures1998
AbstractAbstract
[en] Factors affecting the success of treatment are outlined, and the authors' experience in the radiotherapy of prostate carcinoma are summarized. (P.A.)
Original Title
Moznosti radioterapie u lokalizovaneho karcinomu prostaty
Primary Subject
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Czech Medical Association, Medical Organization Ceske Budejovice, Ceske Budejovice (Czech Republic); 64 p; 1998; p. 11-14; 4. South-Bohemian Oncology Days; IV. jihoceske onkologicke dny; Cesky Krumlov (Czech Republic); 16-18 Oct 1997; 11 tabs.
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Chiruganti, Mohana Vamsy; Dattatreya, Palanki Satya; Shinkar, Pawan Gulabrao; Sharma, Koustubh; Prabhakar Rao, Vatturi Venkata Satya, E-mail: vvs_prabhakar@yahoo.co.uk2015
AbstractAbstract
[en] The authors report an extremely rare occurrence of a massive aneurysm of a major pulmonary artery branch vessel caused by adjacent necrotizing aggressive squamous cell carcinoma metastatic mediastinal nodes. Despite the huge size, there was no hemoptysis due to the walling off effect by the necrotic nodes
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Available from http://dx.doi.org/10.4103/0972-3919.152987; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379684; PMCID: PMC4379684; PMID: 25829743; PUBLISHER-ID: IJNM-30-174; OAI: oai:pubmedcentral.nih.gov:4379684; Copyright: (c) Indian Journal of Nuclear Medicine; This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Indian Journal of Nuclear Medicine; ISSN 0972-3919;
; v. 30(2); p. 174-176

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Schmehl, Jörg; Scharpf, Marcus; Brechtel, Klaus; Kalender, Günay; Heller, Stephan; Claussen, Claus D.; Lescan, Mario, E-mail: joerg.schmehl@med.uni-tuebingen.de2012
AbstractAbstract
[en] Malignancies of the aortic wall represent a rare condition, and only a few reports have covered cases of sarcomas arising at the site of a prosthesis made of Dacron. A coincidence with endovascular repair has only been reported in one case to date. We report a patient with epithelioid angiosarcoma and metastatic disease, which was found in an aneurysmal sac after endovascular aortic repair for abdominal aortic aneurysm.
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Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA)
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AbstractAbstract
[en] Highlights: • Different expressed miRNAs and mRNAs were profiled in lowly and highly metastatic SACC cell lines. • Multiple regulatory interactions between miRNAs and mRNAs may contribute to SACC metastasis. • miR-338–5p/3p and their target LAMC2 function on metastasis of multiple types of cancer. Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in a SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. We discovered that: (1) differentially expressed (DE) mRNAs and DE miRNAs are potentially involved in SACC metastasis; (2) multiple regulatory interactions between DE miRNAs and DE mRNAs exist; and (3) miR-338–5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231 cells. In conclusion, our study integrated the regulatory effects of miRNAs and mRNAs on SACC metastasis and provided a potential application for miRNAs in future therapeutic intervention.
Primary Subject
Source
S0006291X18309008; Available from http://dx.doi.org/10.1016/j.bbrc.2018.04.122; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 500(3); p. 632-638

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