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AbstractAbstract
[en] Metronidazole has been shown to be an active radio-sensitiser of hypoxic cells in vivo and in vitro. In this study 120 persons of different types of cancer were given Metrogyl brand of metronidazole prior to radiation treatment and the results were studied. Metronidazole was found to be effective as a chemical radio-sensitiser since more number of patients in the combined treatment showed effective regression of tumors. (author)
Primary Subject
Source
23 refs.
Record Type
Journal Article
Journal
Indian Journal of Cancer Chemotherapy; CODEN ICCHD; v. 5(1); p. 45-48
Country of publication
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Ermekova, S.A.; Sejtkazina, G.L.
Reparative and compensatory processes in case of radiation injurities1979
Reparative and compensatory processes in case of radiation injurities1979
AbstractAbstract
No abstract available
Original Title
Nekotorye pokazateli ehnergetiki opukholevykh kletok pri radiosensibilizatsii novoobrazovanij metronidazolom
Primary Subject
Source
Tsentral'nyj Nauchno-Issledovatel'skij Rentgeno-Radiologicheskij Inst., Leningrad (USSR); p. 125-126; 1979; p. 125-126; 7. All-union scientist conference on reparative and compensatory processes in case of radiation injurities; Leningrad, USSR; 21 - 23 Nov 1979; Short note.
Record Type
Miscellaneous
Literature Type
Conference
Report Number
Country of publication
ALCOHOLS, ANIMALS, AZOLES, CHEMISTRY, DISEASES, DRUGS, ELEMENTS, HETEROCYCLIC COMPOUNDS, HYDROXY COMPOUNDS, IMIDAZOLES, LYMPHOMAS, MAMMALS, NEOPLASMS, NITRO COMPOUNDS, NONMETALS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOSENSITIZERS, RESPONSE MODIFYING FACTORS, RODENTS, SARCOMAS, VERTEBRATES
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Kalia, Vishal; Vibhuti; Saggar, Kavita, E-mail: v2k1978@yahoo.co.in2010
AbstractAbstract
[en] Metronidazole is a commonly used antimicrobial drug. When used excessively, it can cause encephalopathy. We report the MRI findings in one such case. A 43-year-old male patient was treated with metronidazole for 2 months, for an amebic liver abscess and presented with neurological signs and symptoms. MRI of the brain showed findings consistent with metronidazole toxicity
Primary Subject
Source
Available from http://dx.doi.org/10.4103/0971-3026.69355; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963744; PMCID: PMC2963744; PMID: 21042443; PUBLISHER-ID: IJRI-20-195; OAI: oai:pubmedcentral.nih.gov:2963744; Copyright (c) Indian Journal of Radiology and Imaging; This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Indian Journal of Radiology and Imaging - New Series (Print); ISSN 0971-3026;
; v. 20(3); p. 195-197

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AbstractAbstract
[en] Metronidazole-induced neuro-toxicity, though rare, is known. A characteristic spatial distribution of lesions in cerebellar dentate nuclei and dorsal pons is known. However, temporal progression of lesions on magnetic resonance imaging (MRI) has not been described previously. We describe two such cases which presented initially with splenial hyperintesity and showed progression to characterstic lesions. Both cases improved with stoppage of metronidazole.
Primary Subject
Source
Available from http://dx.doi.org/10.4103/ijri.IJRI_341_16; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510308; PMCID: PMC5510308; PMID: 28744071; PUBLISHER-ID: IJRI-27-129; OAI: oai:pubmedcentral.nih.gov:5510308; Copyright: (c) 2017 Indian Journal of Radiology and Imaging; This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Indian Journal of Radiology and Imaging - New Series (Print); ISSN 0971-3026;
; v. 27(2); p. 129-132

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Karim, A.B.M.F.; Njo, K.H.; The, S.K.; Hasman, A.
Third international meeting on progress in radio-oncology1985
Third international meeting on progress in radio-oncology1985
AbstractAbstract
No abstract available
Primary Subject
Source
Vienna Univ. (Austria). Klinik fuer Strahlentherapie und Strahlenbiologie; 88 p; 1985; p. 36; Third international meeting on progress in radio-oncology; Vienna (Austria); 27-30 Mar 1985; Published in summary form only.
Record Type
Miscellaneous
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Conference
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AbstractAbstract
[en] Metronidazole (MTNZ) is an antiprotozoa drug, could be labeled with the 99mTc. MTZL could be used as an ideal vehicle to deliver radioactive decay energy of 99mTc to the sites of tumor, thus facilitate tumor imaging. The process of labeling was done using tin chloride as reducing agent. The optimum conditions required to label 25 μg MTZL were 100 lg stannous chloride, 30 min reaction time, room temperature at pH 7-9 using 0.5 M phosphate buffer. The radiochemical purity of the labeled compound, at the above conditions, was determined using paper chromatography. The yield was about 93%. About 2.5 x 106 of Ehrlich Ascites Carcinoma (EAC) was injected intrapritoneally (i.p) to produce ascites and intramuscularly (i.m) in the right thigh to produce solid tumor in female mice. Biodistribution studies were carried out by injecting solution of 99mTc-MTZL in normal and tumor bearing mice. The uptake in ascites was over 5% of the injected dose per gram tissue body weight, at 4 h post injection and above 4% in solid tumor. These data revealed localization of the tracer in the tumor tissues with high percentage sufficient to use 99mTc MTZL as promising tool for diagnosis of tumor. (author)
Primary Subject
Secondary Subject
Source
25 refs.
Record Type
Journal Article
Journal
Journal of Radioanalytical and Nuclear Chemistry; ISSN 0236-5731;
; CODEN JRNCDM; v. 281(3); p. 669-674

Country of publication
ALCOHOLS, ANTINEOPLASTIC DRUGS, AZOLES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, DISEASES, DRUGS, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, IMIDAZOLES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, NEOPLASMS, NITRO COMPOUNDS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOISOTOPES, RADIOSENSITIZERS, RESPONSE MODIFYING FACTORS, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
[en] Full text: The presence of hypoxic cells in cancerous lesions is believed to be one of the major reasons for the failure of radiotherapy. Metronidazole is a nitroimidazole derivative which has a tendency to accumulate in the hypoxic regions. Imidazoles are reduced intracellularly in all cells, but in the absence of adequate supplies of oxygen, they undergo further reduction to more reactive products that bind to cell components. The reduction pathway can proceed in successive steps past the hydroxylamine derivative to terminate at the relatively inactive amine derivative. This leads to the possibility of envisaging these compounds as radiosensitive, the agents, which enhance the lethal effect of ionizing radiations for hypoxic tissues. Materials and Methods: Metronidazole was reacted with 2-iodoxybenzoic acid followed by the subsequent reaction with diethylenetriamine resulting into synthesis of Schiff base derivative which was characterized on the basis of spectroscopic techniques. Radiocomplexation was performed with 99mTc for in vivo tumor imaging applications, blood kinetics and biodistribution studies of the radiotracer developed. Result: The newly synthesized Schiff base of metronidazole was fully characterized by spectroscopic techniques, 1H, 13C NMR, mass spectroscopy and IR spectroscopy. The radioconjugate was found to be sufficiently stable in vitro as well as in vivo upto 24 h. Blood clearance of the radiotracer in rabbit was found to be more rapid (t1/2(F)=27±1.4 minutes) and (t1/2(S)=3hr 48±8.4 minutes). The biodistribution in athymic mice showed high tumor uptake (4.93 ± 0.22% ID/g) and low normal organs uptake. Conclusion: Above results showed that 99mTc labeled compound acts as a specific marker accumulated in hypoxic tumor. Excellent biodistribution characteristics support the concept of its utility as specific radiopharmaceutical for imaging hypoxic tumors
Primary Subject
Source
SNMICON-2010: 42. annual conference of the Society of Nuclear Medicine (India) on molecular imaging and targeted radionuclide therapy: predicting the future; Chandigarh (India); 11-14 Nov 2010
Record Type
Journal Article
Literature Type
Conference
Journal
Indian Journal of Nuclear Medicine; CODEN IJNMEK; v. 25(3); p. 78
Country of publication
ALCOHOLS, ANTINEOPLASTIC DRUGS, AZOLES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, DISEASES, DRUGS, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, IMIDAZOLES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, NITRO COMPOUNDS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOACTIVE MATERIALS, RADIOISOTOPES, RADIOSENSITIZERS, RESPONSE MODIFYING FACTORS, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
[en] A conjugate of 6-hydrazinopyridine-3-carboxylic acid (HYNIC) with the amino analogue of metronidazole (MN) was synthesized through a multiple-step reaction. HYNIC-MN could be labeled easily and efficiently with 99mTc using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine -N,N'-diacetic acid (EDDA) as coligands to form the 99mTc-HYNIC-MN complex in high yield (>95%). Its partition coefficient indicated that it was a good hydrophilic complex. The tumor cell experiment showed that the 99mTc-HYNIC-MN complex had a certain hypoxic selectivity. The biodistribution studies of 99mTc-HYNIC-MN in Kunming mice bearing S180 tumor showed a favorable tissue distribution profile with high tumor uptake, and low or negligible accumulation in non-target organs, suggesting 99mTc-HYNIC-MN would be a novel potential tumor hypoxia imaging agent. (author)
Primary Subject
Source
17 refs.
Record Type
Journal Article
Journal
Journal of Radioanalytical and Nuclear Chemistry; ISSN 0236-5731;
; CODEN JRNCDM; v. 287(3); p. 847-852

Country of publication
ALCOHOLS, ANIMALS, ANTINEOPLASTIC DRUGS, AZOLES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, DISEASES, DRUGS, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, IMIDAZOLES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MAMMALS, NITRO COMPOUNDS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOISOTOPES, RADIOSENSITIZERS, RESPONSE MODIFYING FACTORS, RODENTS, TECHNETIUM ISOTOPES, VERTEBRATES, YEARS LIVING RADIOISOTOPES
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INIS VolumeINIS Volume
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Vats, Kusum; Mallia, Madhava B.; Mathur, Anupam; Sarma, Haldhar D.; Banerjee, Sharmila, E-mail: sharmila@barc.gov.in
Proceedings of the thirteenth DAE-BRNS nuclear and radiochemistry symposium2017
Proceedings of the thirteenth DAE-BRNS nuclear and radiochemistry symposium2017
AbstractAbstract
[en] The '4+1' mixed-ligand complexes consist of Tc(III) coordinated to a tripodal tetradentate chelator NS3 (2,2′,2″- nitrilotriethanethiol) and a monodentate isocyanide ligand. Neutral '4+1' mixed ligand complexes could be prepared under mild labeling conditions and they exhibit high stability against ligand exchange in vivo. In the present work, a isocyanide derivative of metronidazole was synthesized for radiolabelling with "9"9"mTc using '4+1' mixed ligand approach. Preliminary biodistribution studies in Swiss mice bearing fibrosarcoma tumor showed uptake and retention of the radiolabeled complex in tumor. (author)
Primary Subject
Source
Mohapatra, M.; Pujari, P.K. (Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai (India)) (eds.); Dash, S. (ed.) (Fuel Chemistry Division, Bhabha Atomic Research Centre, Mumbai (India)); Raskhit, S.K. (ed.) (Product Development Division, Bhabha Atomic Research Centre, Mumbai (India)); Tomar, B.S. (ed.) (Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Mumbai (India)); Bhabha Atomic Research Centre, Mumbai (India); Indian Association of Nuclear Chemists and Allied Scientists, Mumbai (India); KIIT University, Bhubaneswar (India); 750 p; ISBN 81-8372-080-3;
; 2017; p. 488-489; NUCAR-2017: 13. DAE-BRNS nuclear and radiochemistry symposium; Bhubaneswar (India); 6-10 Feb 2017; 4 refs., 1 fig.

Record Type
Book
Literature Type
Conference
Country of publication
ALCOHOLS, ANIMALS, ANTINEOPLASTIC DRUGS, AZOLES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, DISEASES, DRUGS, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, IMIDAZOLES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MAMMALS, NEOPLASMS, NITRO COMPOUNDS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOISOTOPES, RADIOSENSITIZERS, RESPONSE MODIFYING FACTORS, RODENTS, SARCOMAS, TECHNETIUM ISOTOPES, VERTEBRATES, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
[en] Various conservative methods for treatment of labial swelling in patients with granulomatous cheilitis have been attempted, often with only moderate success. We report a case of granulomatous cheilitis who showed excellent sustained response to combination of intralesional steroids, metronidazole and minocycline for initial one month followed by prolonged maintenance treatment with minocycline alone. (author)
Primary Subject
Record Type
Journal Article
Journal
JCPSP. Journal of the College of Physicians and Surgeons Pakistan; ISSN 1022-386X;
; v. 17(9); p. 566-567

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