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[en] When considering the safety of ingested nanomaterials, it is important to quantitate their transfer across intestinal cells; however, little information exists about the effects of nanomaterial size or exposure side (apical versus basolateral epithelial surface) on nanomaterial transfer. Here, we examined cellular internalization and transcellular transport, and the effects of nanomaterials on Caco-2 monolayers after apical or basolateral exposure to Ag or Au nanoparticles with various sizes. After apical treatment, both internalization and transfer to the basolateral side of the monolayers were greater for smaller Ag nanoparticles than for larger Ag nanoparticles. In contrast, after basolateral treatment, larger Ag nanoparticles were more internalized than smaller Ag nanoparticles, but the transfer to the apical side was greater for smaller Ag nanoparticles. Au nanoparticles showed different rules of internalization and transcellular transport compared with Ag nanoparticles. Furthermore, the paracellular permeability of the Caco-2 monolayers was temporarily increased by Ag nanoparticles (5 μg/mL; diameters, ≤10 nm) following basolateral but not apical exposure. We conclude that the internalization, transfer, and effects of nanomaterials in epithelial cell monolayers depend on the size and composition of nanomaterials, and the exposure side. - Highlights: • Ag and Au nanoparticles can transfer across Caco-2 monolayers. • Cellular uptake of nanoparticles change between apical and basolateral exposure. • Basolateral Ag nanoparticle exposure increases the permeability of Caco-2 monolayers.
[en] Modern day microprocessor has increased remarkably in computational capacity which in turn has resulted in generation of higher heat fluxes. Air based conventional heat extraction systems are bungling to eradicate the aforesaid heat fluxes as the need of information technology and high computational facility is skyrocketing. In this present study, numerical simulation is carried out to analyze and compare the thermal performance of a heat pipe combined with forced convection heat transfer mechanism utilizing nanofluids in a mini channel heat sink for application in CPU cooling. Two phase heat transfer phenomenon employed in heat pipe can accomplish extreme heat removal rate. Temperature gradient along with thermal resistance between the coolant and mini channel heated wall is significantly reduced due to the application of nanofluids. Convective heat transfer coefficient at the condenser end of the heat pipe is noticeably improved with application of nanoparticles into distilled water. (author)
[en] NM's potential to induce adverse effects in humans or the environment is being addressed in numerous research projects, and methods and tools for NM hazard identification and risk assessment are advancing. This article describes how integrated approaches for the testing and assessment of NMs can ensure the safety of nanomaterials, while adhering to the 3Rs principle. - Highlights: • Testing each NM in all of its modifications will cause an insurmountable amount of testing. • Integrated approaches for testing and grouping of NM are needed. • Such approaches should take the source-to-adverse-outcome pathways into consideration. • A tiered approach addressing actual concerns with specific NM is proposed.
[en] Incorporation of fulvic acid (FA) into the framework of hydroxyapatite particle to synthesis NHAP functionalized with FA (NHAP-FA) as a new smart nanocomposite is achieved. Some analytical methods such as EDX, FTIR, XRD, and TEM defined it. Preliminary study on the possible radiolabeling of NHAP-FA with 141,143Ce, 152,154Eu, 159,161Gd as represented radio-lanthanides that are gaining more attention in the last decades is carried out. The obtained results were revealed that a significant sorption affinity of radio-lanthanides (∼98%). Application on the environmental remediation towards the removal of some radionuclides (152,154Eu, 60Co, 99Mo, 63Ni and 137Cs) has been evaluated. (author)
[en] A quantitative model for the size-dependent Young’s modulus Y(D) of nanomaterials is established in this work by considering the modulus of single bond and bond number in nanomaterials. Due to bond relaxation, the single bond strength and it’s elastic modulus are enhanced as size drops, while bond number is decreased. This makes the Young’s moduli of nanomaterials possess different change with size. If compared with bulk Young’s modulus Y0, both the stiffer with Y(D) > Y0 and the softer with Y(D) < Y0 for different nanomaterials are predicted. The corresponding experimental or simulation results show their good consistence with the model predictions, which greatly confirms the reasonability of the established model. (paper)
[en] With the evolution of the field of nanomaterials in the past number of years, it has become apparent that it will be key to future technological developments. However, while there are unlimited research undertakings on nanomaterials, limited research results on nanomaterial costs exist; all in spite of the generous funding that nanotechnology projects have received. There has recently been an exponential increase in the number of studies concerning health-related nanomaterials, considering the various medical applications of nanomaterials that drive medical innovation. This work aims to analyze the effect of the cost factor on acceptability of health-related nanomaterials independently or in relation to material toxicity. It appears that, from the materials studied, those used for cancer treatment applications are more expensive than the ones for drug delivery. The ability to evaluate cost implications improves the ability to undertake research mapping and develop opinions on nanomaterials that can drive innovation.
[en] A wide variety of inorganic nanomaterials have been exploited so far for their great potential for biological applications. Some of these materials could be valid candidates to modulate the assembly of amyloid peptides, which is relevant to amyloid-related diseases. In this work, we reveal that a carbon nanomaterial can indeed modulate the assembly of amyloid peptides and, additionally, we show that this modulating effect is closely related to the dimensionality of the nanomaterials. (paper)
[en] Nanomagnetism is the origin of many unique properties in magnetic nanomaterials that can be used as building blocks in information technology, spintronics, and biomedicine. Progresses in nanomagnetic principles, distinct magnetic nanostructures, and the biomedical applications of nanomagnetism are summarized. (topical review - magnetism, magnetic materials, and interdisciplinary research)
[en] As nanostructures with well-controlled dimension, composition, and crystallinity are expected to be a new class of intriguing system for investigating structure-property relations, this review article provides a comprehensive review of researches of these materials and related applications.