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[en] This book discusses carcinomas of the oral cavity including the lymph nodes and salivary glands. Topics include; Epidemiology and etiology; Immunolgical and virological aspects; Basic principles of management; Surgery; Radiotherapy; Chemotherapy; and Cryosurgery
[en] In the period 1981-86, 22 patients with local inoperable tumour recurrences in the mouth and pharynx area had endocavitary contact therapy using a remote-controlled afterloading system at the Radiotherapy Centre of the University of Heidelberg. All patients had had previous surgery and external-beam radiation; some had also received chemotherapy. The technique is described and preliminary results are discussed. (author)
[en] The authors describe an afterloading brachytherapy to treat oral cavity carcinomas. Catheters for arterial/venous catheterization are inserted percutaneously in the target volume. The internal needles are then removed and replaced with iridium wires inside tubes to form wire loops. This technique has proven to be simple, quick and safe. (author). 4 refs.; 1 fig
[en] The purposes of this investigation were to determine the appearance rate of nutrient canals and the aspect of alveolar bone trabecular patterns. 1949 subjects, averages 23 years old, who have normal occlusion were used. The film used in this investigation was full mouth roentgenographic survey. The obtained results were as follows: 1. In the trabecular pattern, coarse form was 35.17%, and fine one was 64.14% in both jaws. 2. The appearance rate of nutrient canals was much higher in mandibular anterior segment(89.13%) than in the maxillary posterior segment(0.86%). 3. In the trabecular forms, small trabecular space and horizontal relation appeared in the mandible, and vertical relation in the maxilla.
[en] The purpose of this study is to investigate possible correlation between the dental anomalies and site of cleft in cleft lip and palate. In this study, 142 patients who had cleft lip and/or cleft palate were examined. The results are as follows. 1. The incidence of missing tooth was high in the permanent dentition as compared to the incidence in the deciduous dentition. 2. There was not much difference of incidence of supernumerary tooth between deciduous and permanent dentition in the group of patients who had cleft lip and jaw with or without cleft palate. 3. In the group of patients who had cleft lip and jaw with or without cleft palate, the frequency of incidence of cleft sides was higher in unilateral than bilateral cases. And, incidence of left sides was higher than right sides. 4. The type of cleft between central incisor and canine with missing lateral incisor was most frequent in permanent dentition and the type of cleft between central and lateral incisor was most frequent in deciduous dentition. 5. The type of cleft associated with tooth position in deciduous dentition was not almost the same in the succeeding permanent dentition.
[en] Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterations in the cadherin-catenin complex are fundamental requirements for the metastasis process, and this is the first study to evaluate the immunostaining of E-cadherin and β-catenin in oral basaloid squamous cell carcinoma. Seventeen cases of this tumor located exclusively in the mouth were compared to 26 cases of poorly differentiated squamous cell carcinoma and 28 cases of well to moderately differentiated squamous cell carcinoma matched by stage and tumor site. The immunostaining of E-cadherin and β-catenin were evaluated in the three groups and compared to their clinicopathological features and prognosis. For groups poorly differentiated squamous cell carcinoma and basaloid squamous cell carcinoma, reduction or absence of E-cadherin staining was observed in more than 80.0% of carcinomas, and it was statistically significant compared to well to moderately differentiated squamous cell carcinoma (p = .019). A strong expression of β-catenin was observed in 26.9% and 20.8% of well to moderately differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma, respectively, and in 41.2% of basaloid squamous cell carcinoma. The 5-year and 10-year overall and disease-free survival rates demonstrated no significant differences among all three groups. The clinical and biological behavior of three groups of the oral cavity tumors evaluated are similar. E-cadherin and β-catenin immunostaining showed no prognostic value for basaloid and conventional squamous cell carcinomas
[en] A critical review was done of forty-seven patients with mouth floor tumors treated at the Department of Radiotherapy of Hospital A.C. Camargo - Fundacao Antonio Prudente - Sao Paulo - Brazil, from 1953 to 1972. Forty-two patients were male and five female. All cases were confirmed hystologically as carcinoma. Epidermoid carcinoma was the most frequent type. The UICC TNM system was adopted for staging lesions. The five year survival was of 53%. The local control of disease was of 72% to T1, 76% to T2 and 43% to T3. Osteoradionecrosis occured in 12,7% of the cases. It is concluded that radio-needle implants must be the first therapeutic approach to the treatment of initial mouth floor tumors. (Author)
[pt]Fez-se uma analise retrospectiva de 47 pacientes portadores de lesao neoplastica do assoalho bucal tratados no Departamento de Radioterapia do Hospital A.C. Camargo da Fundacao Antonio Prudente - Sao Paulo - Brasil. Quarenta e dois pacientes eram do sexo masculino e 5 do feminino numa proporcao de 8:1. Houve confirmacao histologica da neoplasia em todos os casos, mostrando-se o carcinoma espinocelular como o tipo mais frequente. Adotou-se o sistema TNM da UICC para o estadiamento das lesoes. A sobrevida global de 5 anos foi da ordem de 53%. O controle local da doenca foi de 72% para os tumores T1, 76% para os tumores T2 e 43% para os T3. Osteoradionecrose foi a complicacao mais frequente em 12,7% dos casos. Conclui-se que o radium implante deve-se constituir na terapeutica de preferencia para as lesoes iniciais do assoalho bucal. (Autor)
[en] The foot-and-mouth disease virus capsid precursor, P1–2A, is cleaved by the 3C protease (3Cpro) to VP0, VP3, VP1 and 2A. The P1–2A precursor (wt or mutant) was expressed alone or with 3Cpro and processing of P1–2A was determined. The VP2 K217R and VP3 I2P substitutions (near the VP0/VP3 junction) strongly reduced the processing at this junction by 3Cpro while the substitution VP2 K217E blocked cleavage. At the VP3/VP1 junction, the substitutions VP3 Q2221P and VP1 T1P each severely inhibited processing at this site. Blocking cleavage at either junction did not prevent processing elsewhere in P1–2A. These modifications were also introduced into full-length FMDV RNA; only wt and the VP2 K217R mutant were viable. Uncleaved VP0-VP3 and the processed products were observed within cells infected with the mutant virus. The VP0-VP3 was not incorporated into empty capsids or virus particles. The three junctions within P1–2A are processed by 3Cpro independently.
[en] Enterovirus A71 (EV-A71) infection can cause hand, foot and mouth disease (HFMD), and even fatal meningoencephalitis. Unfortunately, there is currently no effective treatment for EV-A71 infection due to the lack of understanding of the mechanism of neurological diseases. In this study, we employed SH-SY5Y human neuroblastoma cells to explore the roles of caspase-1 in neuropathogenesis. The expression and activity of caspase-1 were analyzed. The potential immuneconsequences mediated by caspase-1 including cell death, lysis, DNA degradation, and secretion of pro-inflammatory were also examined. We found the gene expression levels of caspase-1, IL-1β, IL-18 and active caspase-1 were markedly increased in the SH-SY5Y cells at 48 h post EV-A71 infection. The cell death, lysis, and DNA degradation were also increased during infection, which could be significantly alleviated by caspase-1 inhibition. These observations provided additional experimental evidence supporting caspase-1-mediated pyroptosis as a novel pathway of inflammatory programmed cell death.