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[en] This book discusses carcinomas of the oral cavity including the lymph nodes and salivary glands. Topics include; Epidemiology and etiology; Immunolgical and virological aspects; Basic principles of management; Surgery; Radiotherapy; Chemotherapy; and Cryosurgery
[en] In the period 1981-86, 22 patients with local inoperable tumour recurrences in the mouth and pharynx area had endocavitary contact therapy using a remote-controlled afterloading system at the Radiotherapy Centre of the University of Heidelberg. All patients had had previous surgery and external-beam radiation; some had also received chemotherapy. The technique is described and preliminary results are discussed. (author)
[en] The authors describe an afterloading brachytherapy to treat oral cavity carcinomas. Catheters for arterial/venous catheterization are inserted percutaneously in the target volume. The internal needles are then removed and replaced with iridium wires inside tubes to form wire loops. This technique has proven to be simple, quick and safe. (author). 4 refs.; 1 fig
[en] A critical review was done of forty-seven patients with mouth floor tumors treated at the Department of Radiotherapy of Hospital A.C. Camargo - Fundacao Antonio Prudente - Sao Paulo - Brazil, from 1953 to 1972. Forty-two patients were male and five female. All cases were confirmed hystologically as carcinoma. Epidermoid carcinoma was the most frequent type. The UICC TNM system was adopted for staging lesions. The five year survival was of 53%. The local control of disease was of 72% to T1, 76% to T2 and 43% to T3. Osteoradionecrosis occured in 12,7% of the cases. It is concluded that radio-needle implants must be the first therapeutic approach to the treatment of initial mouth floor tumors. (Author)
[pt]Fez-se uma analise retrospectiva de 47 pacientes portadores de lesao neoplastica do assoalho bucal tratados no Departamento de Radioterapia do Hospital A.C. Camargo da Fundacao Antonio Prudente - Sao Paulo - Brasil. Quarenta e dois pacientes eram do sexo masculino e 5 do feminino numa proporcao de 8:1. Houve confirmacao histologica da neoplasia em todos os casos, mostrando-se o carcinoma espinocelular como o tipo mais frequente. Adotou-se o sistema TNM da UICC para o estadiamento das lesoes. A sobrevida global de 5 anos foi da ordem de 53%. O controle local da doenca foi de 72% para os tumores T1, 76% para os tumores T2 e 43% para os T3. Osteoradionecrose foi a complicacao mais frequente em 12,7% dos casos. Conclui-se que o radium implante deve-se constituir na terapeutica de preferencia para as lesoes iniciais do assoalho bucal. (Autor)
[en] The purposes of this investigation were to determine the appearance rate of nutrient canals and the aspect of alveolar bone trabecular patterns. 1949 subjects, averages 23 years old, who have normal occlusion were used. The film used in this investigation was full mouth roentgenographic survey. The obtained results were as follows: 1. In the trabecular pattern, coarse form was 35.17%, and fine one was 64.14% in both jaws. 2. The appearance rate of nutrient canals was much higher in mandibular anterior segment(89.13%) than in the maxillary posterior segment(0.86%). 3. In the trabecular forms, small trabecular space and horizontal relation appeared in the mandible, and vertical relation in the maxilla.
[en] The purpose of this study is to investigate possible correlation between the dental anomalies and site of cleft in cleft lip and palate. In this study, 142 patients who had cleft lip and/or cleft palate were examined. The results are as follows. 1. The incidence of missing tooth was high in the permanent dentition as compared to the incidence in the deciduous dentition. 2. There was not much difference of incidence of supernumerary tooth between deciduous and permanent dentition in the group of patients who had cleft lip and jaw with or without cleft palate. 3. In the group of patients who had cleft lip and jaw with or without cleft palate, the frequency of incidence of cleft sides was higher in unilateral than bilateral cases. And, incidence of left sides was higher than right sides. 4. The type of cleft between central incisor and canine with missing lateral incisor was most frequent in permanent dentition and the type of cleft between central and lateral incisor was most frequent in deciduous dentition. 5. The type of cleft associated with tooth position in deciduous dentition was not almost the same in the succeeding permanent dentition.
[en] Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterations in the cadherin-catenin complex are fundamental requirements for the metastasis process, and this is the first study to evaluate the immunostaining of E-cadherin and β-catenin in oral basaloid squamous cell carcinoma. Seventeen cases of this tumor located exclusively in the mouth were compared to 26 cases of poorly differentiated squamous cell carcinoma and 28 cases of well to moderately differentiated squamous cell carcinoma matched by stage and tumor site. The immunostaining of E-cadherin and β-catenin were evaluated in the three groups and compared to their clinicopathological features and prognosis. For groups poorly differentiated squamous cell carcinoma and basaloid squamous cell carcinoma, reduction or absence of E-cadherin staining was observed in more than 80.0% of carcinomas, and it was statistically significant compared to well to moderately differentiated squamous cell carcinoma (p = .019). A strong expression of β-catenin was observed in 26.9% and 20.8% of well to moderately differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma, respectively, and in 41.2% of basaloid squamous cell carcinoma. The 5-year and 10-year overall and disease-free survival rates demonstrated no significant differences among all three groups. The clinical and biological behavior of three groups of the oral cavity tumors evaluated are similar. E-cadherin and β-catenin immunostaining showed no prognostic value for basaloid and conventional squamous cell carcinomas
[en] Out of a consecutive series of 698 cases of squamous cell carcinomas of the tonsillar region treated by radical megavoltage radiotherapy, a determinate group of 465 cases remained eligible for a multivariate analysis of the pretreatment features of the disease and treatment-related parameters predictive of lasting control of the disease at the primary site. T-stage and initial site within the tonsillar region, were the significant pretreatment factors. Tumours arising from the glossopalatine sulcus which are characterized by involvement of the tongue, do significantly worse than those arising from other sites within the tonsillar region: i.e. the tonsil itself, posterior pillar and to a lesser extent the anterior pillar. As regards treatment related parameters in the 465 cases which received tumour doses of at least 55 Gy, only the length of overall treatment time was found to be predictive. Combining both pretreatment and treatment variables, T-stage (p<0.0001), overall treatment time(p<0.0001) were by decreasing order of significance of predicting factors, followed by initial site (p=0.006). When present, tumour extension to the anatomical structures anterior to the tonsillar region was also found to be significant (p=0.05). Based on these factors, a mutivariate model was constructed and tested by estimating the product-limit survival of the various categories of patients. Four groups are individualized with 3 years local control rates ranging from 90 to 21%. The predictive accuracy of the model was assessed by log-rank test significance levels. The model may help to select patients for whom conventional radical radiotherapy is inadequate, and combined modality or altered fractionation regimes should be tried particularly for advanced tumours of the glossopalatine sulcus, and any case with significant invasion of the oral cavity. (author). 41 refs.; 6 gfigs.; 9 tabs
[en] The purpose of this study was to investigate the radiographic images of the condylar head in clinically normal subjects and the TMJ patients using standardized projection technique. 45 subjects who have not clinical evidence of TMJ problems and 96 patients who have the clinical evidence of TMJ problems were evaluated, but the patients who had fracture, trauma and tumor on TMJ area were discluded in this study. For the evaluation of radiographic images, the author has observed the condylar head positions in closed mouth and 2.54 cm open mouth position taken by the standardized transcranial oblique lateral projection technique. The results were as follow: 1. In closed mouth position, the crest of condylar head took relatively posterior position to the deepest point of the glenoid fossa in 8.9% of the normals and in 26.6% of TMJ patients. 2. In 2.54 cm open mouth position, condylar head took relatively posterior position to the articular eminence in 2 .2% of TMJ patients and 39.6% of the normals. 3. In open mouth position, the horizontal distance from the deepest point of the glenoid fossa to the condylar head was 13.96 mm in the normals and 10.68 mm in TMJ patients. 4. The distance of true movement of condylar head was 13.49 mm in the normals and 10.27 mm in TMJ patients. 5. The deviation of mandible in TMJ patients was slightly greater than of the normals.