[en] Iodinated contrast media (ICM) are introduced into clinical practice at beginning of the twentieth century. Adverse reactions to ICM are not rare and may be caused by toxicity or hypersensitivity reactions. These reactions are generally classified into immediate reactions or delayed reactions. The skin is the most affected organ in both. The diagnosis of ICM hypersensitivity is based on patient´s history, skin tests, in vitro tests and provocation test. The last one is a gold standard for establishing of the diagnosis. Early recognition of adverse reaction is essential for proper treatment. Therefore, the patient should be observed for at least 30 minutes. The therapy of anaphylactic or anaphylactoid reaction consists of pharmacotherapy, oxygen therapy and management of vital functions. Additionally, the value of premedication is considered to be controversial. (author)

[en] A laser amplifier system for the 1.315 μm laser output from the iodine photodissociation laser oscillator is constructed, and its characteristics are investigated. The output energy of the pulsed oscillator using i-C₃F₇I fed into the amplifier is found 20mJ for TEMsub(00) single mode. The maximum output energy extracted from the amplifier is found to be 430mJ and the large single energy gain is 9.1, at the gas pressure 100 torr and the trigger pulse delay time for the oscillator is 5 μsec. The maximum energy extraction efficiency is 0.36 at 20 torr. (Author)

[en] The report describes the development of a radioimmunoassay for 3,3'-L-diiodothyronine (3,3'T₂) which may be performed on unextracted serum. Utilizing a specific antiserum to 3,3'-L-T₂-bovine serum albumin conjugates developed in rabbits, cross-reactivity was less than 0.5% with 3,5,3'-triiodothyronine (T₃) and 3,3',5'-triiodothyronine (reverse T₃) and less than 0.01% with thyroxine (T₄). Intra-assay variation averaged 2.9% and inter-assay variation was 7.8% and 18.5% when serum samples with 3,3'T₂ concentrations of 8 ng/dl and 12 ng/dl, respectively, were analyzed. Assay sensitivity was considered to be 6 ng/dl by statistical criteria. The data suggest that 3,3'T₂ circulates in the serum of normal individuals and tends to parallel serum concentrations of T₃, T₄ and rT₃ in various states of thyroid function

[en] The carbon-13 NMR data of all possible isomeric iodo-substituted thiophenes are discussed. (Author)

[en] A rapid method for the preparation of the radioiodinated 15-(4-iodophenyl)pentadecanoic acid (p-IPPA) was developed. ¹³¹I-p-IPPA was obtained from the corresponding tin precursor and ¹³¹I-iodide using Chloramine-T as an oxidant in a radiochemical yield of 90 ± 1.4% with a radiochemical purity > 99% when performing the labeling at room temperature within a reaction time of 3 min. The study of dependences on temperature (0, 20 and 80 deg C) and reaction time (1, 3, 5, 10 and 30 min) showed no yield increase with higher temperatures and prolonged reaction times but the formation of side products. (author

[en] Raman- and infrared absorption spectra for iodoxibenzene from 4000 to 30 cm^-₁ in the solid state is described. The region 800 to 650 cm^-₁ and the vibration absorption bands of the IO² groups are discussed in detail. (ARHC)

No abstract available

[en] The ¹²⁵I-human fibrinogen test was introduced in Hungary applying a Hungarian made equipment produced by the Gamma Works. 131 investigations have been carried out so far and the method proved to be useful for both the control of the post-operative period and the diagnosis of suspected thrombosis. (L.E.)

[en] In the treatment of adrenergic tumors with MIBG, therapeutic success depends on tumor avidity for MIBG. We recently presented a scintigraphic method for the quantification of MIBG avidity of the tumor. This method was further used in our clinical routine. The present paper reports on its significance for planning MIBG therapy, which was investigated in a larger group of patients (pts). Nine pts with neuroblastoma (NB) and a pt with metastatic pheochromocytoma (MMP) received altogether 31 therapeutic doses of MIBG. Repeat diagnostic gamma camera scintigrams were recorded and serial post-treatment scintigrams were obtained after the administration of the therapeutic doses. Background activity (BG) was determined by ROI in the left mid abdomen. Cpm obtained within standardized BG and tumor (T) ROIs were recorded and uptake ratios (UR) were calculated for the tumor (TUR) as follows: (cpmsub(T) - cpmsub(BG))/ cpmsub(BG). A close correlation was found between TUR measured after diagnostic doses and those measured after the 1st therapeutic dose up to 12 dpi. Thus, tumor avidity for a therapeutic MIBG dose could be predicted by a diagnostic dose. Serial post-treatment scintigrams at about weekly intervals showed decreasing values in most of the pts. The usefulness of determining TUR is evident especially for optimal planning of MIBG therapy, i.e. for the estimation of the radiation doses before the beginning of the treatment and for the avoidance of repeat administrations of therapeutic doses at moments of minimum avidity of the tumor for MIBG. According to our experience, rapidly growing NB should be treated with high MIBG doses given at short intervals. Therapy may be extended in MMP. (Author)

No abstract available