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[en] The Batho Biomedical Facility is dedicated to an investigation of the efficacy of pion radiation for the treatment of malignant disease. During the period 1974-1976 it progressed from a completely 'paper' project to an operational beam with support systems, and many of the necessary physical characterizations of the beam were completed. Development of much of the equipment and procedures for the residual beam measurements were completed, particularly for dosimetric measurements of the beam. Studies of ways to control the beam characteristics in order to deliver specified dose distributions to tumour volumes were at an early stage. Initial in vitro biological measurements of cell survival as a function of depth were made. (LL)
[en] Dynamic spot scanning with pions of patients with pelvic and abdominal malignancy has demonstrated to date that treatments are well tolerated, that early response rates are favorable, and that morbidity, which is volume and dose related, has been within clinically acceptable limits. The search for optimum treatment factors proceeds
[en] The parameters calculated in part 1 of this series devoted to the application of the general RBE theory to negative pions, represent the characteristics of radiation energy deposition that enter into the theory. These implicitly include the customary microdosimetric quantities, too, which now are calculated explicitly and compared to experimental data. Good agreement is found with respect to single-event spectra and their mean values for different components and interaction modes and at different positions in the pion beam. These results support the physical side of the approach in general and, in particular, the simplifications and approximations used to treat pions in this way. (author)
[en] The RBE theory is based on general microdosimetric concepts and can, therefore, be applied to any kind of ionizing radiation. Application to pions is made feasible by calculating the inherent physical parameters of the theory, which depend on characteristics of radiation energy deposition, for different positions in and components of a pion beam. Emphasis is placed on rationalizing and simplifying the physical fundamentals to start with (radiation field composition, modes and products of interaction) and presenting the final results in a comprehensive and practicable form. (author)
[en] The NA62 experiment at CERN SPS aims to collect O(100)K2+→π+νν events in two years of data taking with a S/B ratio of about 10:1. The Branching Ratio (BR) for this decay is ∼10-11 and can be predicted with minimal theoretical uncertainties, making it a sensitive probe for New Physics. The guiding principles for the construction of the NA62 detectors are an accurate particle ID, precise timing and excellent veto efficiency. In particular, the veto inefficiency for photons from K+→π+π0 decays should be smaller than 10-8. The photon veto system of NA62 consists of three detectors covering different angular regions: Large Angle Veto (LAV), Liquid Krypton calorimeter (LKr) and Small Angle Veto (SAV). The status of the project and present preliminary results from the recent tests will be reviewed.