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[en] The development of the eye in vertebrates is dependent upon glucocorticoid signalling, however, specific components of the eye are sensitive to synthetic glucocorticoids. The presence of synthetic glucocorticoids within the aquatic environment may therefore have important consequences for fish, which are heavily reliant upon vision for mediating several key behaviours. The potential ethological impact of synthetic glucocorticoid oculotoxicity however has yet to be studied. Physiological and behavioural responses which are dependent upon vision were selected to investigate the possible toxicity of prednisolone, a commonly occurring synthetic glucocorticoid within the environment, during early life stages of zebrafish. Although exposure to prednisolone did not alter the morphology of the external eye, aggregation of melanin within the skin in response to increasing light levels was impeded and embryos exposed to prednisolone (10 μg/l) maintained a darkened phenotype. Exposure to prednisolone also increased the preference of embryos for a dark environment within a light dark box test in a concentration dependent manner. However the ability of embryos to detect motion appeared unaffected by prednisolone. Therefore, while significant effects were detected in several processes mediated by vision, changes occurred in a manner which suggest that vision was in itself unaffected by prednisolone. Neurological and endocrinological changes during early ontogeny are considered as likely candidates for future investigation. - Highlights: • The oculotoxicity of prednisolone was assessed during zebrafish embryogenesis. • Exposure to 10 μg/l resulted in a darkened phenotype during light adaptation. • Preference for a dark environment was differentially altered by prednisolone. • The detection of motion appeared unaffected by all concentrations of prednisolone. • Effects are hypothesised to be mediated via non-visually controlled pathways. - Exposure to prednisolone alters physiological and behavioural responses to visual stimuli during zebrafish embryogenesis via proposed non-ocular mechanisms.
[en] A competitive protein binding technique for the determination of plasma prednisolone in dexamethasone-treated men was found suitable for the estimation of plasma levels of a new non-steroidal compound having a chemical structure related to that of prednisolone. The method used allowed to determine the time of appearance of this compound in the peripheral plasma after oral administration, the time of the peak and the apparent disappearance half-life which were comparable to that of prednisolone
[fr]Le dosage par radiocompetition peut etre applique, chez l'homme prealablement traite a la dexamethasone, a la determination des taux plasmatiques d'une substance non steroide de structure chimique proche de celle de la prednisolone. Cette methode rapide et precise a permis de mesurer les parametres pharmacodynamiques (delai d'apparition dans le plasma apres administration orale, moment du maximum et temps de demi-disparition qui sont comparables a ceux qui ont ete determines pour la prednisolone
[en] To determine the kinetics of metabolism and interconversion of prednisolone and prednisone, the plasma levels of these synthetic glucocorticoids were measured by new radioimmunoassays (RIA) after intravenous (iv) or oral administration to normal humans. Following the iv injection of prednisolone phosphate in 8 normal subjects, the mean half-time of prednisolone was 240 +- 20 min (mean +- SE) and the metabolic clearance rate was 82 +- 7.2 1/24 h/m2. Of 10 mg of prednisone given orally to 5 normal subjects, 69 +- 5 percent was absorbed and converted to peripheral plasma prednisolone within 8h. The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation of prednisone by oxidation of the 11-hydroxyl group of prednisolone appears to occur mainly in peripheral tissues
[en] A 31-year old Filipino male presented with bifrontal throbbing headache and blurring of vision of 2 weeks duration. He was initially seen by an internist who considered a space occupying lesion based on the signs and symptoms and on his funduscopic findings of beginning papilledema. CT scan ruled out the presence of a tumor and he was then referred to the Opthamology Department. Ocular findings revealed bilateral panuveitis with retinal detachment of the left eye. A diagnosis of Vogt-Koyanagi-Harada syndrome was made and therapy with high dose systemic prednisolone was instituted which resulted in rapid improvement and the attainment of a good visual activity. (author). 3 refs.; 1 fig
[en] Objective: The role of methyl prednisolone in longitudinal extensive transverse myelitis in children is not completely discovered in developing country like Pakistan. So this is the first study which aimed to evaluate the efficacy of methyl prednisolone in longitudinal extensive transverse myelitis in children. Methods: This is quasi experimental hospital based descriptive prospective study. The data was collected from 34 children admitted in Paediatric Neurology department through Outpatient/emergency department in Children’s Hospital and the Institute of Child Health, Lahore for period of one year from January 2018 to December 2018. The children full filling the inclusion criteria were observed before and after giving injection methyl prednisolone 30mg/kg/dose (maximum dose one Gram irrespective of the body weight) once daily for five days in the form of intravenous infusion. Results: Complete recovery was seen in 41.2% while 58.8% showed partial recovery. The correlation of response to treatment (recovery) with gender, area of spinal cord involvement, muscle power and autonomic dysfunction is found at significance level of five percent according to Chi square test. Conclusion: Early consideration and administration of methyl prednisolone in longitudinally extensive transverse myelitis in children can be beneficial and can help to reduce the morbidity.
[en] Eighteen children suffering from Non-Hodgkin's lymphoma were studied. Of these eighteen children, eight (44.4 percent) had well differentiated diffuse lymphocytic lymphoma and six (33.3 percent) had poorly differentiated diffuse lymphocytic lymphoma and four (22.3 percent) had histiocytic lymphoma. Histological study was based on the concept of Rappaport (1966). Children belonging to Stage IIB were treated with radiotherapy followed by combination chemotherapy and those with Stage IIIB and Stage IVB were treated with combination chemotherapy utilising cyclophosphamide, oncovin and prednisolone. The result of combination chemotherapy (COP) was dramatic and appears to have resulted in long term disease free survival. In well differentiated diffuse lymphocytic lymphoma in Stage IIB the life expectancy of two children was extended to 12 years with well maintained remission for 9.5 years. Recurrence rate was 44.4 percent. Death rate was 61.1 percent and median survival time was 26.7 months. In histiocytic lymphomas the results were unsatisfactory. Median survival time was 9.5 months. (author)
[en] The authors report their experience in the percutaneous treatment of simple bone cysts by intra-cystic local infiltrations of methylprednisolone acetate. In particular, the method adopted, the evolution of the radiologic picture and the results, achieved are described. Sixty patients were successfully treated without complications or surgery. (orig.)