Results 1 - 10 of 6986
Results 1 - 10 of 6986. Search took: 0.045 seconds
|Sort by: date | relevance|
[en] Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor (GR). Since, the alterations in GRα translational isoforms have been documented in psychiatric disorders we sought to: 1) explore whether multiple GRα isoforms in the human peripheral blood mononuclear cells of two independent cohorts (whole cell n = 40; and nuclear extracts n = 43, adult subjects) mediate the effect of CT on negative affectivity (NA) measured by Depression, Anxiety and Stress Scales (DASS), and 2) examine their role/function during fear extinction in the animal model. In multiple regression analysis, CT, nuclear 40-kDa GRα their interactions and FKBP5 explained 22%–35% of variance in DASS scores. Structural equation modeling showed that CT had a significant direct effect on 40-kDa and DASS in both cohorts, and on the nuclear 25-kDa GRα. The association between 40-kDa and total DASS was significantly mediated by nuclear FKBP5, whereas on DASS anxiety, over FKBP5 in both cohorts and nuclear full length GRα. Nuclear 40-kDa GRα and its interaction with CT had a significant direct effect on DASS anxiety. In mice, the successful extinction learning was followed by nuclear translocation of 40-kDa GRα and induction of BDNF exon IV expression. Our data revealed that the association between CT and adult NA in non-clinical subjects is mediated by the GRα translational isoforms, in particular 40-kDa GRα and emphasized its role in fear extinction and neural plasticity. © 2018 Elsevier Inc.
[en] This paper deals with the well-known discrepancy principle of Morozov. We show that the principle can be used as an a posteriori choice rule for determining the regularization parameter of Tikhonov regularization considering more general penalty terms than the classical quadratic one. We show regularization properties as well as convergence rates
[en] It was given a statistical treatment for the geochemical data about soil in the are named Alvo2 - Corpo4- in the Provincia Mineral de Carajas, Para, Brazil, for application of the geological mapping and definition of geochemical anomalies. (A.B.)
[pt]Realizou-se um tratamento estatistico de dados geoquimico de solo, na area denominada Alvo 2 - Corpo 4, na Provincia Mineral de Carajas, Para, Brasil, para a aplicacao no mapeamento geologico e definicao de anomalias geoquimicas.(A.B.)
[en] To assess the immunization status of children aged 12-23 months and its determinants in Aden, Yemen. This cross-sectional survey was conducted between March and July 2007 during which time mothers of 680 children from 37 randomly selected clusters in Aden, were interviewed. Information on socio-demographic profiles and children's immunization status was obtained. Immunization coverage of all officially provided vaccines was assessed. Analysis of association between immunization coverage and the socio-demographic characteristics were tested using logistic regression analysis with the immunization status as the dependent variable. We found that 83.1% had complete, 10.4% had partial, and 6.5% were never immunized. The immunization card retention rate was 84.9%. The immunization coverage was 92.9% for Bacillus-Calmette-Guerin, 89.6% for Oral Polio Vaccine-3, 86.6% for Diphtheria, Pertusis and Tetanus-3 and Hepatitis-B vaccination, and 89.1% for measles. Multivariate analysis showed that children with an immunization card (odds ratio [OR]=14.71; 95% confidence interval [CI]: 8.50-25.44) were more likely to have complete immunization, while children with older aged mothers (OR=0.41; 95% CI: 0.22-0.77) were more likely to have complete immunization. Despite the high immunization coverage, 16.9% of children did not have complete immunization, and this rate was lower among children of older mothers, and those who retained their immunization cards. Raising awareness of immunization and increasing access to health services must be strengthened (Author).
[en] Work is described which uses a method for the identification of noise sources - the multivariate auto regressive process. Analyses were performed using simulated noise and operating nuclear power plant process noise. The simulated noise signals are generated mathematically in the same way as the system structure identified by the AR-method. The analysis of the simulated noise shows the possibility of the method to identify a simulated stochastic system and to clarify the influence of the different noise sources. Auto power spectrum of nuclear power plant signals calculated by the AR-method are in good agreement with FFT (Fast Fourier Transform) calculations. The contributions to the noise from the different sources calculated by the AR-program are in agreement with expected characteristics from physical considerations. (U.K.)
[en] The purpose of this study was to investigate the immediate and long-term results of cryoplasty versus conventional balloon angioplasty in the femoropopliteal artery of diabetic patients. Fifty diabetic patients (41 men, mean age 68 years) were randomized to cryoplasty (group CRYO; 24 patients with 31 lesions) or conventional balloon angioplasty (group COBA; 26 patients with 34 lesions) of the femoropopliteal artery. Technical success was defined as <30% residual stenosis without any adjunctive stenting. Primary end points included technical success, primary patency, binary in-lesion restenosis (>50%), and freedom from target lesion recanalization. Cox proportional hazards regression analysis was performed to adjust for confounding factors of heterogeneity. In total, 61.3% (19 of 31) in group CRYO and 52.9% (18 of 34) in group COBA were de novo lesions. More than 70% of the lesions were Transatlantic Inter-Society Consensus (TASC) B and C in both groups, and 41.4% of the patients in group CRYO and 38.7% in group COBA suffered from critical limb ischemia. Immediate technical success rate was 58.0% in group CRYO versus 64.0% in group COBA (p = 0.29). According to 3-year Kaplan-Meier estimates, there were no significant differences with regard to patient survival (86.8% in group CRYO vs. 87.0% in group COBA, p = 0.54) and limb salvage (95.8 vs. 92.1% in groups CRYO and COBA, respectively, p = 0.60). There was a nonsignificant trend of increased binary restenosis in group CRYO (hazard ratio [HR] 1.3; 95% CI 0.6-2.6, p = 0.45). Primary patency was significantly lower in group CRYO compared with group COBA (HR 2.2; 95% CI 1.1-4.3, p = 0.02). Significantly more repeat intervention events because of recurrent symptoms were required in group CRYO (HR 2.5; 95% CI 1.2-5.3, p = 0.01). Cryoplasty was associated with lower primary patency and more clinically driven repeat procedures after long-term follow-up compared with conventional balloon angioplasty.
[en] Highlights: • The limit for aging time to keep tensile strength is 10,000 h for 550 °C. • No degradation of ductility was detected after all the aging examined. • The strength degradation is described by time-temperature equivalence parameters. - Abstract: The present study conducted tensile tests on F82H steel after aging at 400–650 °C for 1000–30,000 h, and discusses the process for change in tensile properties during the long-term aging, combined with previous study for 100,000 h aging. The limit for aging time to keep tensile strength is more than 100,000 h for 400 and 500 °C aging, 10,000 h for 550 °C, 3000 h for 600 °C, and less than 1000 h for 650 °C. While, no degradation of ductility was detected after all the aging examined. Regression analyses were performed with Hollomon-Jaffe parameter and Lambda parameter on the degradation of tensile strength during aging, and prior tempering in the heat treatment before the aging. Lambda parameter analysis successfully derived a master curve to describe the tensile strength after the long-term aging.
[en] An analogue of confidence intervals with a given level of possibility for output variable in a fuzzy linear regression model has been developed in the paper. The methods of fuzzy regression analysis extend the methods of classical regression analysis and allow to solve different problems in conditions of fuzzy and incomplete initial information without the limits of the probabilities methods. The developed approach opens up new opportunities for predicting of output fuzzy variable. (paper)
[en] The theory of regression and statistical analysis as it applies to reservoir analysis was discussed. It was argued that regression lines are not always the final truth. It was suggested that regression lines and eyeballed lines are often equally accurate. The many conditions that must be fulfilled to calculate a proper regression were discussed. Mentioned among these conditions were the distribution of the data, hidden variables, knowledge of how the data was obtained, the need for causal correlation of the variables, and knowledge of the manner in which the regression results are going to be used. 1 tab., 13 figs