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[en] A technique for the treatment of retinoblastoma is described. It ensures treatment of the whole retina as far forward as the ora serrata without irradiating the lens
Journal
Australasian Radiology; ISSN 0004-8461; 
; v. 27(1); p. 8-10
; v. 27(1); p. 8-10
No abstract available
Journal
[en] Three cases of postradiation retinopathy are reported. The findings are analysed. The exudates described by many authors are really infarcts of the choroid lobules. Chorioretinopathy is proposed as a better descriptive term, and three types are suggested. Diagnosis of the condition is important to spare unnecessary enucleation, as the infarcted areas may resemble a recurrence. Predisposing factors are discussed. (author)
Journal
[en] In this contribution we examine a methodology to avoid parasitic cross-correlation terms in spectral optical coherence tomography (SOCT) images. The optimal conditions of optical power and exposure time are found theoretically and confirmed experimentally to ensure that parasitic images are hidden under the shot noise. An upper limit on useful exposures may then be estimated. In a case of SOCT imaging of the retina this limit is below the ANSI safety limit
Journal
[en] Retinoblastoma is the most common intraocular malignant tumor in children. Previous investigations have reported that buthionine sulfoximine (BSO) can deplete intracellular glutathione (GSH) by specific inhibition and increase cellular radiosensitivity. The toxic effects, GSH depletion and radiosensitivity effects of BSO on retinoblastoma cells are reported in this paper. GSH content of retinoblastoma cell lines Y-79, So-Rb50 and retinoblastoma xenograft is 2.7 ± 1.3 X 1.0-12 mmol/cell, 1.4 ± 0.2 X 1.0-12 mmol/cell, and 2.8 ± 1.2 μmol/g, respectively. The ID50 of BSO on Y-79 and So-Rb50 in air for 3 h exposure is 2.5 mM and 0.2 mM, respectively. GSH depletion by 0.1 mM BSO for 24 h on Y-79 cells and 0.01 mM BSO for 24 h on So-Rb50 cells is 16.35%, and 4.7% of control. GSH depletion in tumor and other organ tissues in retinoblastoma-bearing nude mice after BSO administration is differential. GSH depletion after BSO exposure in Y-79 cells in vitro decreases the Do value of retinoblastoma cells. The SER of 0.01 mM and 0.05 mM BSO for 24 h under hypoxic conditions is 1.21 and 1.36, respectively. Based on these observations, the authors conclude that BSO toxicity on retinoblastoma cells depends on the characteristics of the cell line and that BSO can increase hypoxic retinoblastoma cells' radiosensitivity in vitro. Further study of BSO radiosensitization on retinoblastoma in vivo using nude mouse xenografts is needed. 25 refs., 3 figs., 3 tabs
Journal
International Journal of Radiation Oncology, Biology and Physics; ISSN 0360-3016; ; CODEN IOBPD3; v. 29(2); p. 393-396
; CODEN IOBPD3; v. 29(2); p. 393-396
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