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Quintero, C.M.; Freire, D.Y.
Direccion General de Energia Nuclear, Guatemala City (Guatemala)1993
Direccion General de Energia Nuclear, Guatemala City (Guatemala)1993
AbstractAbstract
[en] The purpose of this was the modification of labelled autologous red blood cells in vivo/in vitro. Evaluation consisted in different combinations of Tc-99m radiopharmaceuticals as pyrophosphate (PYP) and stannous chloride (SnCl2), anticoagulants as heparin and acid-citrate-dextrose (ACD), and oxidant agents as hydrogen peroxide (H2O2) and sodium hypochlorite (NaClO); factorial block design was carried out to determinate which one brings a better yield of labelling, and more advantages of availability. Results showed that all tested combinations were above 90% labelled; variance analysis indicated significant difference between the two radiopharmaceuticals (P<0.05), being higher percent of labelling with PYP than SnCl2, and PYP-ACD-NaClO the best combination. It was demonstrated that the procedure is safe because hemocultives realized during the labelling process were all negative, evidencing no bacterial contamination. There were significant erythrocyte-shape modifications, too. Due to low costs and good availability of H2O2 as oxidant agent there were no statistic significant differences between the use of H2O2 or NaClO, the modification PYP-ACD-H2O2 will be used as scintigraphic test for deep vein thrombosis
Original Title
Modificacion de la marcacion de eritrocitos autologos con Tc-99m para la evaluacion centellografica del sistema venoso profundo
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Source
Ciencia y Tecnologia Nuclear; v. 1(1-2); 1993; 5 p; Also available from Direccion General de Energia Nuclear
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Miscellaneous
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AbstractAbstract
[en] Some factors affecting the biodistribution of radiopharmaceuticals in patients are discussed. These include concomitant drug therapy, contamination of radiopharmaceuticals during dispensing or injection into the patient, prior administration of diagnostic contrast media and prior administration of another radiopharmaceutical. (UK)
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Source
Theobald, A.E. (ed.) (Chelsea Coll. of Science and Technology, London (UK)); 221 p; ISBN 0-85066-318-0;
; 1985; p. 189-205; Taylor and Francis; London (UK)

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Book
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AbstractAbstract
[en] SIRT5 is one of the seven mammalian sirtuins which are NAD+-dependent deacylases. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. Previous studies have focused mostly on SIRT5iso1. Characteristics regarding localization, activity and tissue distribution of the other three SIRT5 isoforms remain unclear. In the present study, we characterized these properties of these SIRT5 isoforms. We found that SIRT5iso1−3 were mitochondria-localized, while SIRT5iso4 localized mainly in cytoplasm. SIRT5iso2−4 had little deacylase activity comparing with SIRT5iso1. Although cDNAs of all SIRT5 isoforms were readily detected in multiply tissues according to EST database, proteins of SIRT5iso2−4 were seldom observed in human cell lines. Altogether, we dissected the four isoforms of human SIRT5 protein.
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S0006291X18313858; Available from http://dx.doi.org/10.1016/j.bbrc.2018.06.073; Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Biochemical and Biophysical Research Communications; ISSN 0006-291X;
; CODEN BBRCA9; v. 503(2); p. 763-769

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Logan, J.; Alexoff, D.; Fowler, J.S.
Brookhaven National Laboratory (United States). Funding organisation: DOE - Office Of Science (United States)2011
Brookhaven National Laboratory (United States). Funding organisation: DOE - Office Of Science (United States)2011
AbstractAbstract
[en] Graphical analysis (GA) is an efficient method for estimating total tissue distribution volume (VT) from positron emission tomography (PET) uptake data. The original GA produces a negative bias in VT in the presence of noise. Estimates of VT using other GA forms have less bias but less precision. Here, we show how the bias terms are related between the GA methods and how using an instrumental variable (IV) can also reduce bias. Results are based on simulations of a two-compartment model with VT's ranging from 10.5 to 64 mL/cm3 and from PET image data with the tracer (11C)DASB ((11C)-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl) benzonitrile). Four estimates of VT (or distribution volume ratio (DVR) using a reference tissue) can be easily computed from different formulations of GA including the IV. As noise affects the estimates from all four differently, they generally do not provide the same estimates. By taking the median value of the four estimates, we can decrease the bias and reduce the effect of large values contributing to noisy images. The variance of the four estimates can serve as a guide to the reliability of the median estimate. This may provide a general method for the generation of parametric images with little bias and good precision.
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BNL--95031-2011-JA; KP1602010; AC02-98CH10886
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[en] An improved quantitative immuno chemical determination of tyrosine hydroxylase brain concentrations was designed by using direct transfer into nitro-cellulose from 20 μm thick brain sections followed by immuno-detection and quantitative radioautography
[fr]
Le transfert direct d'antigenes cerebraux proteiques solubles sur nitro-cellulose a partir de coupes de cerveau (20 μm) permet une analyse quantitative de grande resolution anatomique de la distribution cerebrale de la tyrosine hydroxylase par immuno-chimie et radioautographie quantitative. La sensibilite (1/1 000 de locus caeruleus de rat) et la reproductibilite de la methode sont discuteesOriginal Title
Mesure par radioautographie quantitative des concentrations de la Tyrosine Hydroxylase cerebrale: etude anatomique apres transfert direct des proteines solubles sur nitro-cellulose
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Journal Article
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Comptes Rendus de l'Academie des Sciences. Serie 3; ISSN 0764-4469;
; CODEN CRASE; v. 306(14); p. 457-461

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AbstractAbstract
[en] Bone scintigrams are usually obtained for evaluation of skeletal abnormalities; soft-tissue abnormalities are often an unexpected finding. However, the recognition of specific conditions with extraskeletal accumulation of bone-seeking radiopharmaceuticals greatly enhances the diagnostic value of the study. Several examples of abnormal nonosseous uptake in both neoplastic and nonneoplastic processes involving the brain, lung, heart, breast, bowel, liver, spleen, skeletal muscle, kidney, and bladder are presented. Examples of artifactual uptake in the soft tissues are also described. Causes for nonosseous accumulation are discussed.21 references
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Gaspar, P.F.; Mastro, N.L. de.
Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)1990
Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)1990
AbstractAbstract
[en] Published in summary form only
Original Title
Estudos da biodistribuicao de compostos ricos em boro-10 para utilizacao em BNCT (boron neutron capture therapy)
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Source
1990; 1 p
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Miscellaneous
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LanguageLanguage
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AbstractAbstract
[en] SPECT imaging with 123I-labeled methyl 3β-(4-iodophenyl)tropane-2β-carboxylate ([123I]β-CIT) in nonhuman primates has shown brain striatal activity, which primarily reflects binding to the dopamine transporter. The biodistribution and calculated radiation-absorbed doses of [123]β-CIT administered to eight healthy subjects were measured with attention to the accurate determination of organ time-activity data. Whole-body transmission images were obtained with a scanning line source for attenuation correction of the emission images. Following administration of 92.5 ± 22.2 MBq (2.5 ± 0.6 mCi) of [123I]β-CIT, subjects were imaged with a whole-body imager every 30 min for 3 hr, every 60 min for the next 3 hr and at 12, 24 and 38 hr postinjection. Regional body conjugate counts were converted to microcuries of activity, with a calibration factor determined in a separate experiment using a distributed source of 123I. The peak brain uptake represented 14% of the injected dose, with 2% of the activity approximately overlying the striatal region. Highest radiation-absorbed doses were to the lung (0.1 mGy/MBq, 0.38 rads/mCi), liver (0.087 mGy/MBq, 0.32 rads/mCi) and lower large intestine (0.053 mGy/MBq, 0.20 rads/mCi). Iodine-123-β-CIT is a promising SPECT agent for imaging of the dopamine transporter in humans with favorable dosimetry and high brain uptake. 18 refs., 4 figs., 5 tabs
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Kiesewetter, D.O.; Lee, J.T.; Lang, Lixin; Park, S.G.; Paik, Chang H.; Eckelman, W.C.
208th ACS national meeting1994
208th ACS national meeting1994
AbstractAbstract
[en] The authors have synthesized a number of fluorine-containing compounds of two known muscarinic receptor ligand classes and evaluated these analogs for subtype selectivity using the NOVASCREEN tissue subtype assays. Fluorine-containing analogs of the antagonist quinuclidinyl benzilate (QNB) were prepared in a stereoselective manner and the various isomers were found to display differing affinities in the tissue subtype assays. Fluorine-containing analogs of the agonist 3-(3-(alkylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine [TZTP] were also prepared and observed to display differences in subtype selectivity. Biodistribution studies have been conducted with some of these analogs to study in vivo selectivity
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Source
Anon; 2072 p; 1994; p. 1080, Paper NUCL 54; American Chemical Society; Washington, DC (United States); 208. American Chemical Society national meeting; Washington, DC (United States); 21-26 Aug 1994; American Chemical Society, 1155 16th St., NW, Washington, DC 20036-4899 (United States)
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Book
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Conference
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AbstractAbstract
[en] Published in summary form only
Original Title
Quelques considerations sur les differents vecteurs radioactifs a tropisme melanique
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Source
3. Nuclear medicine French-Belgian meeting; Lyon (France); 27 Feb 1987
Record Type
Journal Article
Literature Type
Conference
Journal
Journal de Biophysique et de Biomecanique; CODEN JBNDD; v. 11(3); p. 126
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