An improved method of synthesis of per-6-deoxy-6-iodo-beta-cyclodextrin

A number of per-6-substituted-6-deoxy-β-cyclodextrin derivatives have been synthesized for many years, of them, per-6-deoxy-6-iodo-β-cyclodextrin is of great importance in supramolecular chemistry. By reviewing all published papers related to synthesis of per-6-deoxy-6-iodo-β-cyclodextrin and combining with our experimental verification, this work has reported an improved method of synthesis of per-6-deoxy-6-iodo-β-cyclodextrin. The approach mainly uses adding a certain amount of methanol instead of removing DMF before adjusting pH. We think this project is simple, efficient, high repeatable and suitable for large-scale preparation, superior even to all the previously reported methods. The synthesis of bromo, chloro substituted -per-6-β-CD may also refer to this improved method. At the same time, the detailed introduction of operation process and precautions will serve as a reference and guidance to the beginner who will engage in the study on the chemical synthesis reaction of sugar and cyclodextrin. (author)