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AbstractAbstract
[en] For a 70-kg man injected intravascularly with a typical 25 ml of Thorotrast (approximately 0.6μCi232Th), the dose-rate to the endosteum, 0-10 μm from bone surfaces, is estimated at roughly 16 rad/yr, of which 7 rad/yr is from 224Ra, 228Th, and 228Ra translocated from Thorotrast to calcified bone, and 9 rad/yr is from Thorotrast on bone surfaces and in red marrow. Additional dosimetric analyses are needed to refine these provisional estimates. For the induction of osteosarcomas in the Thorotrast patients, it is possible that the most important dose is from the 224Ra continually deposited on all bone surfaces, rather than from the focal aggregates of Thorotrast which irradiate fewer bone cells but kill with multiple α-particles a higher fraction of those cells that are irradiated. (author)
Primary Subject
Secondary Subject
Source
Biological effects of 224Ra and thorotrast. International symposium; Alta, Utah, USA; 21 - 23 Jul 1974
Record Type
Journal Article
Literature Type
Conference
Journal
Health Physics; ISSN 0017-9078;
; v. 35(1); p. 123-125

Country of publication
ACTINIDE COMPOUNDS, ACTINIDE NUCLEI, ALPHA DECAY RADIOISOTOPES, ANIMAL CELLS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CHALCOGENIDES, COLLOIDS, CONNECTIVE TISSUE, CONNECTIVE TISSUE CELLS, CONTRAST MEDIA, DAYS LIVING RADIOISOTOPES, DISEASES, DISPERSIONS, EVEN-EVEN NUCLEI, HEAVY NUCLEI, HEMATOPOIETIC SYSTEM, INJECTION, INTAKE, ISOTOPES, KINETICS, NEOPLASMS, NUCLEI, ORGANS, OXIDES, OXYGEN COMPOUNDS, PATHOGENESIS, RADIOCOLLOIDS, RADIOISOTOPES, RADIUM ISOTOPES, SARCOMAS, SKELETAL DISEASES, SOMATIC CELLS, THORIUM COMPOUNDS, THORIUM ISOTOPES, THORIUM OXIDES, TISSUES, YEARS LIVING RADIOISOTOPES
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